Essential Guide to Reading Biomedical Papers Recognising and Interpreting Best Practice

Dr Philip Langton is currently a Senior Lecturer and Academic Director of e-Learning in the Faculty of Medical and Veterinary Sciences at the University of Bristol, UK.  Dr Langton is an advocate for excellence in all forms of learning, teaching and assessment in HE.  He is an enthusiastic undergraduate and graduate teacher, contributing to Medical Sciences and Physiological Sciences programmes. Finalist of ‘Bioscience Teacher of the Year’ for 2011, Dr Langton is passionate about providing an excellent learning experience for students in ways that are stimulating and rewarding for University staff, and disseminating innovative and high-quality learning practices. 

List of Contributors

Foreword

Preface

0 INTRODUCTION

Section A - Basic Principles

1 PHILOSOPHY OF SCIENCE

2 EXPERIMENTAL DESIGN

3 STATISTICS

Section B - Cell and molecular

4 ORGAN BATH PHARMACOLOGY

5 SMALL ARTERY MYOGRAPHY

6 PREPARATION AND USE OF PRIMARY CELL CULTURES

7 ELECTRON MICROSCOPY [TEM & SEM]

8 FLUORESCENCE MICROSCOPY

9 INTRACELLULAR MICROELECTRODE RECORDING

10 SINGLE ELECTRODE VOLTAGE-CLAMP

11 PATCH CLAMP RECORDING

12 ANTIBODIES (PRODUCTION OF)

13 IMMUNOHISTOCHEMISTRY (AKA IMMUNOCYTOCHEMISTRY)

14 IMMUNOPRECIPITATION (IP)

15 IMMUNO (WESTERN) BLOTTING

16 APPLICATIONS OF GREEN FLUORESCENT PROTEIN (GFP)

17 FLUORESCENT MEASUREMENT OF ION ACTIVITY IN CELLS

18 EXOCYTOSIS - REAL TIME DETECTION

19 VIRAL VECTOR TRANSGENESIS

20 POLYMERASE CHAIN REACTION (PCR)

21 IN-SITU HYBRIDISATION (ISH)

22 METHODS OF INTERFERENCE (ANTISENSE, SIRNAS AND DOMINANT NEGATIVE MUTATIONS)

23 MICROARRAY/CHIP ANALYSIS

24 PROTEOMICS

Section C - In vivo / Integrative

25 ANIMAL BEHAVIOUR STUDIES

26 GENETICALLY MODIFIED MOUSE MODELS

27 IN VIVO RECORDING BY TELEMETRY

28 ELECTRICAL STIMULATION METHODS

29 EXTRACELLULAR RECORDING 

30 ANTIDROMIC IDENTIFICATION

31 EVENT- TRIGGERED AVERAGING INCLUDING SPIKE-TRIGGERED AVERAGING

32 AXONAL TRANSPORT TRACING OF CNS PATHWAYS

33 GENERAL CONSIDERATIONS FOR HUMAN STUDIES

34 CARDIAC OUTPUT - IN HUMANS

35 PERIPHERAL BLOOD FLOW - IN HUMANS

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