Evolutionary Biology Cell-Cell Communication, and Complex Disease

, by Torday, John S.; Rehan, Virender K.

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ISBN: 9780470647202 | 0470647205
Cover: Hardcover
Copyright: 2/21/2012

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This book presents a unique treatise on the application of evolutionary biology, functional genomics, and cell communication studies to complex disease. Its contents focus on emprically derived data rather than association studies, leading towards a model for the formulation of testable hypotheses in complex disease studies, rather than a symptom-based, descriptive approach. This provides a deeper understanding of the way genes relate to the health states and traits of living organisms.

Preface	p. xi
About the Authors	p. xiii
The Cellular Origin Of Vertebrates	p. 1
The Origins of Unicellular Life on Earth	p. 1
Prokaryotes versus Eukaryotes	p. 4
Coevolution of traits	p. 5
Cholesterol Facilitates Lipid Rafts for Cell-Cell Communication	p. 7
The Endomembrane System	p. 9
The Cellular Mechanism of Evolution	p. 10
Why Evolve?	p. 11
Cell-Cell Communication and Aging	p. 12
Reducing Lung Physiology To Its Molecular Phenotypes	p. 17
Hormonal Acceleration of Lung Development	p. 17
Neutral Lipid Traffi cking and Lung Evolution	p. 19
Other Examples of Cellular Cooperativity	p. 23
Summary	p. 24
A Cell-Molecular Strategy For Solving The Evolutionary Puzzle	p. 25
Rationale for Cell-Molecular Evolution	p. 25
Mechanism of Mammalian Lung Development	p. 28
Avian Lung Structure-Function Relationship: The Exception that Proves the Rule	p. 32
Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung Development	p. 32
Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny?	p. 33
The Evolution Of Cell-Cell Communication	p. 35
Cell-Cell Communication as the Mechanistic Basis for Evolutionary Biology	p. 36
The Darwinian Biologic Spacetime Continuum and Einstein's Vision of the Universe	p. 37
Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution	p. 38
Cell-Cell Communication as the Basis for the Evolution of Metazoans	p. 41
Understanding Lung Evolution from the Middle Out	p. 42
The Cell-Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes	p. 43
Predictive Value of the Lung Cell-Cell Communication Model for Understanding the Evolution of Physiologic Systems	p. 44
Sexual Dimorphism of Lung Development: A Case Study in Cell-Cell Communication and Evolutionary Plasticity	p. 46
Androgen Affects the Expression of Growth Factors Involved in Lung Development	p. 48
Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes	p. 49
How To Integrate Cell-Molecular Development, Homeostasis, Ecology, And Evolutionary Biology: The Missing Links	p. 53
Neutral Theory versus Intelligent Design	p. 54
Internal Selection Theory	p. 54
The Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle	p. 57
The Continuum from Microevolution to Macroevolution	p. 58
cis Regulation and Adaptive Evolution	p. 69
Evolution of cis Regulatory Mechanisms	p. 70
From Cell-Cell Communication To The Evolution Of Integrated Physiology	p. 75
Cell-cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits	p. 77
An Integrated, Empiric, Middle-Out Approach to Physiology	p. 79
A Molecular Evolutionary Link between the Lung and the Kidney?	p. 82
The Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi broblast	p. 83
Lung Biology as a Cipher for Evolution	p. 85
Do Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity?	p. 85
Wolff's Law Works for Both Bone and Lung	p. 88
Functional Relationship between the External and Internal Environments	p. 89
An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid	p. 91
Exploiting Cell-Cell Communication Across Spacetime To Deconstruct Evolution	p. 95
Somewhere between the Gene and the Phenotype Lies the Process of Evolution	p. 98
A Functional Genomic Approach to Evolution as an Example of Terminal Addition	p. 100
Seeking Deep Homologies in Lung Evolution	p. 102
Systems Biology Based on Cell-Cell Communication	p. 105
Vertical Integration of Leptin Signaling, Human Evolution, and the Trojan Horse Effect	p. 108
Leptin and Human Evolution: Food for Thought	p. 109
The Periodic Table Of Biology	p. 115
The Prospect of a Periodic Table of Biology	p. 115
Cellular Cooperation Is Key	p. 116
Elemental Biology	p. 118
PTHrP as an Archetype	p. 118
Evolution as the Solution	p. 119
Ramping Up a Mathematical Model of Evolution	p. 121
The Anthropic Principle Results from the Evolution of Cell-Cell Interactions	p. 124
Value Added By Thinking In Terms Of The Cell-Cell Communication Model For Evolution	p. 125
This is Not a Just-So Story	p. 126
Beyond Genomics	p. 128
From Fat Cells to Integrated Physiology	p. 128
Molecular Homologies Distinguish between the Evolutionary Forest and Trees	p. 129
The Oxygen-Cholesterol-Surfactant-Membrane Connection	p. 130
Cholesterol Metabolism as the Data Operating System for Vertebrate Biology?	p. 131
Translation of Genomics into the Periodic Table for Biology	p. 132
Deep Homologies	p. 134
Selection Pressure for Cell-Cell Communication: The Key to Understanding Evolution	p. 135
Cell-Cell Communication As The Basis For Practicing Clinical Medicine	p. 139
Cell-Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively	p. 140
Cell-Cell Communications as a Framework for Human Evolution	p. 140
Canalization, Decanalization, and the Holistic Approach to the Practice of Medicine	p. 141
Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease	p. 141
Lung Evolution Explains the Magic of Continuous Positive Airway Pressure	p. 142
The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection	p. 143
Exploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage	p. 144
The Trojan Horse Effect of Canalization	p. 145
Impetus for Evolutionary Science as an Integral Part of the Clinical Curriculum	p. 146
Application of Evolutionary Science to Bioethics	p. 147
Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of Biology	p. 148
Summary	p. 149
Name Index	p. 151
Subject Index	p. 153
Table of Contents provided by Publisher. All Rights Reserved.

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Evolutionary Biology Cell-Cell Communication, and Complex Disease

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