Fibrous Proteins: Coiled-Coils, Collagen and

Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is available online on ScienceDirect full-text online of volumes 53 onwards. *Reveals new structural and functional aspects of fibrous proteins *Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry

PREFACE

xi

Fibrous Proteins: New Structural and Functional Aspects Revealed

DAVID A.D. PARRY AND JOHN M. SQUIRE

I. Introduction

2

(1)

II. a-Fibrous Proteins

2

(4)

III. Connective Tissue

6

(3)

IV. Summary

9

(3)

Structural and Functional Implications of Sequence Repeats in Fibrous Proteins

DAVID A.D. PARRY

I. Introduction

12

(1)

II. Sequence Regularities

13

(2)

III. Effect of Sequence Repeats on Secondary Structure, and Implications for Tertiary and Quaternary Structure

15

(15)

IV. Summary

30

(2)

References

32

(5)

The Structure of α-Helical Coiled Coils

ANDREI N. LUPAS AND MARKUS GRUBER

I. Historical Introduction

37

(3)

II. Structural Parameters

40

(16)

III. Structural Determinants of Folding and Stability

56

(4)

IV. Structural Diversity

60

(10)

V. Function Follows Structure

70

(2)

References

72

(8)

The Design of Coiled-Coil Structures and Assemblies

DEREK N. WOOLFSON

I. Introduction to Protein Design

80

(2)

II. Rules for Coiled-Coil Design: The Basics of Coiled-Coil Sequence and Structure

82

(10)

III. Key Coiled-Coil Designs

92

(13)

IV. Summary

105

(1)

References

106

(8)

Microdissection of the Sequence and Structure of Intermediate Filament Chains

DAVID A.D. PARRY

I. Introduction

114

(2)

II. Sequence Regularities and Characteristics, and Their Effects on Secondary and Tertiary Structure

116

(20)

III. Summary

136

(1)

References

137

(7)

Intermediate Filament Associated Proteins

KATHLEEN J. GREEN, MICHAEL BÖHRINGER, TODD GOCKEN AND JONATHAN C.R. JONES

I. Introduction

144

(2)

II. Plakin Family

146

(13)

III. Cell Surface-IF Interactions

159

(9)

IV. Other Crosslinkers not in the Plakin Family

168

(5)

V. IFAPs as Participants in a Signaling Scaffold and Cellular Metabolism

173

(5)

VI. Motors that Move IFs

178

(2)

VII. The Fine Line between IFs and IFAPs

180

(1)

VIII. Conclusions and Future Directions

181

(1)

References

182

(22)

Spectrin, α-Actinin, and Dystrophin

M.J.F. BRODERICK AND S.J. WINDER

I. Introduction

204

(1)

II. Evolution

205

(3)

III. Structure

208

(2)

IV. Function

210

(11)

V. Regulations of Interactions

221

(6)

VI. Disease

227

(5)

VII. Conclusions

232

(1)

References

233

(15)

Fibrinogen and Fibrin

JOHN W. WEISEL

I. Introduction

248

(3)

II. Structure and Properties of Fibrinogen

251

(9)

III. Biosynthesis and Metabolism of Fibrinogen

260

(3)

IV. Conversion of Fibrinogen to Fibrin

263

(10)

V. Binding of Other Proteins to Fibrin(ogen)

273

(2)

VI. Fibrinolysis

275

(2)

VII. Fibrinogen Binding to Integrins in Platelet Aggregation and Other Cellular Interactions

277

(2)

VIII. Dysfibrinogenemias, Variants, and Heterogeneity of Fibrinogen

279

(4)

IX. Evolution of Fibrinogen and Fibrinogen-Like Domains

283

(1)

X. Conclusions

284

(1)

References

285

(17)

Molecular Structure of the Collagen Triple Helix

BARABARA BRODSKY AND ANTON V. PERSIKOV

I. Introduction

302

(1)

II. The Biological Role and Occurrence of the Collagen Triple-Helix Motif in Proteins

303

(4)

III. Molecular Structure: Collagen and Collagen Model Peptides

307

(12)

IV. Mechanism of Hydroxyproline Stabilization

319

(4)

V. Breaks in the Gly-X-Y Repeating Pattern

323

(1)

VI. Amino Acid Sequence and Stability

323

(3)

VII. Ligand Binding

326

(3)

VIII. Mutations and Disease

329

(3)

IX. Conclusions

332

(1)

X. Abbreviations and Notation

332

(1)

References

333

(9)

Collagen Fibril Form and Function

T.J. WESS

I. Introduction

342

(1)

II. The Collagens that Constitute Fibrils

342

(3)

III. Fibrillar Molecular Packing

345

(5)

IV. Lateral Packing in Fibrillar Collagens

350

(4)

V. Novel Fibrillar Structures

354

(2)

VI. Subfibrillar Structures

356

(1)

VII. Fibril Surface

356

(1)

VIII. Factors that May Regulate Fibril Growth and Size

357

(2)

IX. Distribution of Fibril Sizes

359

(2)

X. Suprafibrillar Architectures

361

(4)

XI. Mechnical Properties of Collagen-Rich Tissues

365

(1)

XII. Conclusions

366

(1)

References

367

(8)

Molecular Packing in Network-Forming Collagens

CARLO KNUPP AND JOHN M. SQUIRE

I. Introduction

375

(2)

II. Network-Forming Collagens in Detail

377

(15)

III. Intertwining of Network Collagens: The Type VI Segmented Supercoil

392

(4)

IV. Common Structural Themes in Network-forming Collagens

396

(3)

References

399

(7)

Fibrillin Microfibrils

CAY M. KIELTY, MICHAEL. J. SHERRATT, ANDREW MARSON AND CLAIR BALDOCK

I. Introduction

406

(1)

II. Fibrillin Molecules

406

(6)

III. Fibrillin Assembly

412

(5)

IV. Microfibril Organization and Elasticity

417

(3)

V. Fibrillin-1 Alignment Models

420

(6)

VI. Fibrillin Microfibrils in Aging and Disease

426

(3)

VII. Summary

429

(1)

References

429

(9)

Elastin

SUZANNE M. MITHIEUX AND ANTHONY S. WEISS

I. Elastic Fiber

438

(2)

II. Elastogenesis

440

(6)

III. Properties of Elastin

446

(3)

IV. Mechanism of Elasticity

449

(1)

V. Biomaterials

450

(3)

References

453

(10)

AUTHOR INDEX

463

(44)

SUBJECT INDEX

507

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Fibrous Proteins: Coiled-Coils, Collagen and Elastomers

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