Fundamental Neuropathology for Pathologists

This book offers toxicologists an introduction to the discipline and techniques of neuropathology including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

BRAD BOLON, DVM, MS, PhD, Diplomate ACVP, Diplomate ABT, Fellow ATS, Fellow IATP, has spent over twenty years as a practitioner and teacher of toxicologic neuropathology. He is the founder of GEMpath, Inc., an experimental pathology consultancy specializing in drug discovery research.

MARK T. BUTT, DVM, Diplomate ACVP, is the founder of Tox Path Specialists, LLC, a company that provides neuropathology and histology support to pharmaceutical and biotechnology firms developing novel therapies that target nervous system diseases. He has over twenty years' experience providing neuropathology support and has evaluated over four hundred studies supporting regulatory submissions for neuroactive compounds.

Editors' Preface
Forward
Acknowledgments
Fundamentals of Neurobiology
Fundamentals of Toxicologic Neuropathology: An Introduction
Functional Neuroanatomy
Atlas of Comparative Neuroanatomy
Principles of Comparative and Correlative Neurodevelopment, and their Implications for Developmental Neurotoxicity
Localizing Neuropathologic Lesions Using Neurologic Findings
Behavioral Model Systems for Evaluating Neuropathology
Cognitive Assessments in Non-Human Primates
The Impact of Aging on Brain Structure and Function in Rodents and Canines
Fundamentals of Neurotoxicity Detection
Toxicologic Neuropathology: Methodology
Practical Neuropathology of the Rat and Other Species
The Fluoro-Jade Dyes: Novel, Sensitive, and Reliable Fluorochromes for the Histochemical Localization of Degenerating Neurons
Histologic Markers of Neurotoxicity (Nonfluorenscence)
Common Histologic Artifacts in Nervous System Tissues
High-Definition Microscopic Analysis of the Nervous System
Stereological Solutions for Common Quantitative Endpoints in Neurotoxicity
Anatomy and Processing of Peripheral Nerve Tissues
Pathology Methods in Non-clinical Neurotoxicity Studies: Evaluation of Muscle
In Vivo Imaging Applications for the Nervous System in Animal Models
Cerebrospinal Fluid Analysis in Toxicologic Neuropathology
Molecular Techniques in Toxicologic Neuropathology
Toxicologic Neuropathology: Current Practices
Evaluation of the Adult Nervous System in Preclinical Studies
Pathology Methods in Non-clinical Neurotoxicity Studies: Developing Central Nervous System
Neuropathology Analysis of the Peripheral Nervous System
Toxicologic Pathology of the Retina and Optic Nerve
Toxicologic Neurpathology of the Ear
Neurpathology of the Olfactory System
Applied Toxicologic Neuropathology
Spinal Delivery and Assessment of Drug Safety
Diagnostic Neuropathology
Toxicologic Neuropathology in Medical Practice
Toxiciologic Neuropathology in Veterinary Practice
Regulatory Considerations in Toxicologic Neuropathology
The Neuropathology Report and the Neuropathology Peer Review Report
Preparation of Personnel for Neuropathology Assessment
Regulatory Guide to the Histopathologic Assessment of Neurotoxicity Studies
Toxicologic Neuropathology: The Next Two Decades
Appendices
Ready References of Neurobiology Knowledge
Neural Cell Markers of Potential Utility for Toxicologic Neuropathology Applications
Neuroanatomic Atlases for Toxicologic Neuropathology Studies
Text-Based Basic Neurobiology References for Toxicologic Neuropathologists
Web-Based Neurobiology References for Toxicologic Neuropathogists
Toxicologic Neuropathology References for Nervous System Targets
Comparative and Correlative Neurobiological Parameters Related to Neuropathology Assessment
Comparison of Central Nervous System Proportions Between Humans and Rats
Chemical Composition of Central Nervous System Tissues and Fluids
Table of Contents provided by Publisher. All Rights Reserved.

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Fundamental Neuropathology for Pathologists and Toxicologists Principles and Techniques

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Author Biography

Table of Contents

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