Genomics and Clinical Medicine

An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad rangeof genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas ofmedicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.

i. List of Contributors. ii. Acknowledgements. iii. Foreword. iv. Preface. v. Glossary: Selected terms and phrases in Genetics and Genomics. SECTION 1: GENERAL GENOMICS. 1. From Genes to Genome- a historical perspective2. The Human Genome - structure and organization3. Human functional genomics and proteomics4. Epigenomics and human disease5. Genomic perspectives of human development6. Genetic and Genomic approaches to Taxonomy of Human Disease7. Genomic technologies8. Nutritional genomics9. Pharmacogenomics: drug development, drug response and precision medicinesSECTION 2: CLINICAL GENOMICS. 10. Clinical medicine in the Genome era- an introduction11. Complex cardiovascular disorders12. Diabetes mellitus and obesity13. Chronic renal disease14. Haemostasis and thrombosis15. Disorders of platelets16. Applications in Critical Care Medicine17. Seizure disorders18. Neurodegenerative disorders: Tauopathies and Synucleinopathies19. Neuropsychiaric diseases I: Schizophrenia20. Neuropsychiatric diseases II: Mood disorders21. Asthma and Chronic Obstructive Pulmonary Disease22. Inflammatory Bowel Disease23. Cancer genomics: mechanisms, diagnosis and therapeutic implications2425. Infectious diseases: susceptibility, resistance, response, and anti-microbial therapy26. Chronic inflammatory disorders27. Immunological disorders28. Applications in Clinical Pediatrics29. Learning and behavioural disorders30. Complex Ophthalmic disorders31. Applications in Audiological Medicine32. Complex skin diseases I: Psoriasis33. Complex skin diseases II: Atopic dermatitis34. Complex skin diseases III: Diseases of the epidermis and appendages, skin pigmentation and skin cancer35. Osteoporosis and related disorders36. Applications in Obstetrics and Gynaecology and Reproductive medicine37. Stem cell genomics, Cell-based therapy and Regenerative medicineSECTION 3: HEALTH GENOMICS. 38. Genomics and global health39. Genetic testing and genomic screening40. Ethical issues in human genomics41. The regulation of human genomics researchUseful on-line genetic and genomic contact addresses. Index.