Growth Hormone Secretagogues in Clinical Practice

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ISBN: 9780824798321 | 0824798325
Cover: Hardcover
Copyright: 4/28/1998

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Furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, & clinical applications of GH secretagogues, including orally active & xenobiotic GH-releasing compounds. Contains contributions by eminent international figures in the field, including Nobel Laureate in Medicine, Dr. Andrew V. Schally.

Preface

iii

Contributors

xiii

Part I: Scope of Non-GHRH Growth Hormone Secretagogues

Synergistic Release of Growth Hormone by GHRP and GHRH: Scope and Implication

(26)

Cyril Y. Bowers

Structural Requirements of Growth Hormone Secretagogues

(10)

Romano Deghenghi

Unifying Mechanism of a Non-GHRH Growth Hormone Secretagogues Action

(20)

Roy G. Smith

Molecular Cloning and Characterization of Human, Swine, and Rat Growth Hormone Secretagogue Receptors

(20)

Lex H. T. Van der Ploeg

Andrew D. Howard

Roy G. Smith

Scott D. Feighner

A Mathematical Model of Growth Hormone Release from the Pituitary

(18)

David Brown

Elinor A. Stephens

Gareth Leng

Roy G. Smith

Evidence for a New Subtype of GHRP Receptors in Ovine Pituitary Gland

(12)

Chen Chen

Danxing Wu

Iain J. Clarke

The Design, Synthesis, and Biological Activities of a Series of Tetrahydroquinoline- and Isoindoline-Based Growth Hormone Secretagogues

107

(14)

Bruce A. Lefker

Philip A. Carpino

Lydia C. Pan

Kristin L. Chidsey-Frink

Paul DaSilva Jardine

Frank M. DiCapua

David A. Griffith

William A. Hada Jr.

John K. Inthavongsay

Sharon K. Lewis

F. Michael Mangano

Marianne C. Murray

OiCheng Ng

Jane G. Owens

Christine M. Pirie

Colin R. Rose

Nancy I. Ryan

John R. Schafer

John L. Tucker

Ann S. Wright

Michael P. Zawistoski

David D. Thompson

Development of a New and Simple Screening System for the Evaluation of Growth Hormone Secretagogues

121

(10)

Vojislav Pejovic

Jelena Joksimovic

Vukic Soskic

Part II: Experimental Pharmacology

Agonistic Analogs of Growth Hormone-Releasing Hormone: Endocrine and Growth Studies

131

(14)

Andrew V. Schally

Ana Maria Comaru-Schally

Antagonistic Analogs of Growth Hormone-Releasing Hormone: Endocrine and Oncological Studies

145

(18)

Andrew V. Schally

Magdolna Kovacs

Katalin Toth

Ana Maria Comaru-Schally

Clinical Evidence for Extrahypophyseal Action Site of Growth Hormone Secretagogues

163

(10)

Eva Maria Carro

Dragan Micic

Vera Popovic

Manuel Pombo Arias

Alfonso Leal-Cerro

Roberto Peino

Carlos Dieguez

Felipe F. Casanueva

Electrophysiological Studies of the Arcuate Nucleus: Central Actions of Growth Hormone Secretagogues

173

(14)

Gareth Leng

Alex R. T. Bailey

Suzanne L. Dickson

Roy G. Smith

Effects of a Growth Hormone-Releasing Peptide-like Nonpeptidyl Growth Hormone Secretagogue on Physiology and Function in Aged Rats

187

(22)

Richard F. Walker

Barry B. Bercu

Anterior Pituitary Function in Prolonged Critical Illness: Effects of Continuous Infusion of Growth Hormone Secretagogues

209

(12)

Greet Van den Berghe

Francis de Zegher

Roger Bouillon

Johannes D. Veldhuis

Cyril Y. Bowers

Hepatic Extraction of Hexarelin, a New Peptidic Growth Hormone Secretagogue, in the Isolated Perfused Rat Liver

221

(10)

Marie Roumi

Sylvie Marleau

Muny Franklin Boghen

Magnus H. L. Nilsson

Romano Deghenghi

Patrick du Souich

Huy Ong

The Effect of Growth Hormone Secretagogues on the Release of Growth Hormone-Releasing Hormone, Somatostatin, Vasopressin, and Corticotrophin-Releasing Hormone from the Rat Hypothalamus In Vitro

231

(20)

Maria Korbonits

John A. Little

Mary L. Forsling

Alfredo Costa

Giuseppe Tringali

Pierluigi Navarra

Peter J. Trainer

Michael Besser

Ashley Grossman

Immunocytochemical Studies Investigating the Central Actions of the Nonpeptidyl Growth Hormone Secretagogue, MK-0677

251

(14)

Alex R. T. Bailey

Gareth Leng

Roy G. Smith

Neurochemical Identification of the Cells Expressing c-fos mRNA in the Rat Arcuate Nucleus Following Systemic Growth Hormone-Releasing Peptide-6 Injection

265

(14)

Suzanne L. Dickson

Simon M. Luckman

Do Growth Hormone-Releasing Peptides Play a Role in the Neurohypophysis?

279

(6)

Bjarne Fjalland

Thomas Anderson

Peter B. Johansen

Part III: Clinical Applications of Growth Hormone Secretagogues

Evaluation of Pituitary Function Using Growth Hormone Secretagogues

285

(20)

Barry B. Bercu

Richard F. Walker

Clinical Use of Growth Hormone Secretagogues

305

(24)

Mark A. Bach

Short- and Long-Term Growth Hormone Secretagogue Administration in Children

329

(16)

Zvi Laron

Endocrine Response to Growth Hormone-Releasing Peptides Across Human Life Span

345

(24)

Ezio Ghigo

Emanuela Arvat

Laura Gianotti

Lidia Di Vito

Fabio Broglio

Giampiero Muccioli

Franco Camanni

GHRH and GHRP-6 Exert Different Effects on Sleep Electroencephalogram and Nocturnal Hormone Secretion in Normal Men

369

(16)

Axel Steiger

Ralf-Michael Frieboes

Harald Murck

Reproductibility of the Growth Hormone Response to Hexarelin in Children and the Effect of Sex Steroids

385

(10)

Sandro Loche

Annamaria Colao

Marco Cappa

Bartolomeo Merola

Jaele Bellone

Gianluca Aimaretti

Giovanni Farello

Antonella Faedda

Gaetano Lombardi

Romano Deghenghi

Ezio Ghigo

Leukocytic Interferon-α Is Able to Reduce Growth Hormone Response to GHRH in Patients with Active Chronic Hepatitis: Preliminary Data

395

(10)

Domenico Valle

Laura De Marinis

Antonio Mancini

Lucia Puglisi

Gian Lodivico Rapaccini

Giovanni Gasbarrini

Effects of Growth Hormone Secretagogues Inside and Outside the Hypothalamic-Hypophyseal System

405

(12)

John-Olav Jansson

Johan Svensson

Bengt-Ake Bengtsson

Eva Sjogren-Jansson

Anders Lindahl

Ola Nilsson

B. Hakan Ahlman

Bo Wangberg

Michael Nilsson

Lawrence A. Frohman

Rhonda D. Kineman

Growth Hormone-Releasing Effect of Hexarelin, a Synthetic GHRP, and GHRH in Children and Adults with Down Syndrome

417

(10)

Letizia Ragusa

Antonino Alberti

Corrado Romano

Caterina Proto

Fabio Colabucci

Maria Rosa Valetto

Laura Gianotti

Jaele Bellone

Gianluca Aimaretti

Emanuela Arvat

Ezio Ghigo

Romano Deghenghi

The Critical Importance of Growth Hormone-Releasing Hormone Signaling for Growth Hormone Secretion: Lessons from the Dwarfs of Sindh

427

(6)

Hiralal G. Maheshwari

Gerhard Baumann

Index

433

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Growth Hormone Secretagogues in Clinical Practice

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Table of Contents

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