Haemophilia and Haemostasis: A Case-Based

This unique book covers the major cases one might encounter in diagnosing, managing and treating haemophilia. It will provide a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.Haemophilia and Haemostasis: A Case-based Approach to Management is divided into major chapter sections by disorder. Each chapter contains questions and cases that were originally submitted to the online Haemostasis-forum (previously Haemophilia-forum). Cases and questions associated with each disorder are presented alongside practical answers from a wide range of international contributors.Practical, clinical questions, answered by the world's leading experts All case studies gathered from the Archives of the Haemostasis/Haemophilia Forum - 1997-2006 Covers haemophilia, Von Willebrand Disease and many other bleeding and clotting disorders Over 80 case studies with practical answers To reflect varying practice, controversial areas will be clearly marked and discussed throughoutWhether you are a practising clinician or trainee in haematology, working in the fields of coagulation, haemostasis or thrombosis, or any other health care professional working in a haemophilia centre, this book will provide practical clinical answers to aid in your day to day patient care.

Harold Roberts, MD, ex-Senior Associate Editor of the Journal of Thrombosis and Haemostasis and Chairman, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA.

Dr Roberts, a Sarah Graham Kenan Professor of Medicine and Pathology at the UNC-Chapel Hill School of Medicine, was born in Four Oaks and grew up in Sanford. He earned his undergraduate and medical degrees from UNC-Chapel Hill, joined the faculty in 1962 and has served as chief of the division of hematology and director of the UNC-Chapel Hill Comprehensive Hemophilia Diagnostic and Treatment Center. He was also the founding director of the school's Center for Thrombosis and Hemostasis, which conducts research on blood clotting disorders related to cardiovascular disease and on bleeding disorders such as hemophilia. He has served on the editorial boards of Current Opinion in Hematology and Hematologic Pathology, as well as being senior associate editor of Thrombosis and Haemostasis.

Excellence in laboratory research and patient care earned Dr. Roberts numerous awards: the French International Prize for Research on Hemophilia, the National Hemophilia Foundation's Kenneth M. Brinkhous Award for Excellence in Clinical Research, and the Robert P. Grant Medal, the highest honor given by the International Society on Thrombosis and Haemostasis. The citation accompanying this award lauded him as "one of the pioneers in the field of coagulation as well as being a leader in the Chapel Hill group which has brought so much to our present understanding of the subtleties in the mechanisms of coagulation. His contributions to our field have had a major impact, especially his outstanding work on the genetic basis of hemophilia."

In spring of 2000, Dr. Roberts received the UNC Medical Alumni Association's Distinguished Faculty Award and an honorary doctor of medicine degree from Lund University in Sweden.

Daniel Carrizosa, MD, Consultant Hematologist, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA.

Alice Ma, MD, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA.

List of Haemostasis Forum Editors
List of Contributors
Preface
Hemophilia A and Hemophilia
General Overview
Hemophilia and Immune Tolerance Therapy
The Hemophilic Ankle: An update
The Hemophilic Knee: An update
Issues with Complicated Diagnoses
Combined Hemophilia A and B Carrier
A Complex Case of Hemophilia with HIV and Hepatitis
A Case of Hemophilia B, Mild VWD and a Factor IX Inhibitor
Premature Infant with Hemophilia
Hemophilic Carriers
Hemophilic Carriers and Delivery
Mild Hemophilia in Women
Treatment of the Pregnant Hemophiliac
Anticoagulation and Hemophilia
Anticoagulation for Atrial Fibrillation in a Hemophiliac
Anticoagulation for a Cardiac Valve in a Hemophiliac
Cardiac Catheterization in a Hemophilia
Anticoagulation for a DVT in a Hemophiliac
Treatment of Hemophiliacs
DDAVP for Treatment of Mild Hemophilia during Surgery
Hemophilia and Hemodialysis
Hemophilia and Hepatitis C Treatment
Hemophilia and Physical Therapy
Hemophilia and Renal Bleeds
Hemophilia and SCUBA Diving
Hemophilia and Ventricular Septal Defect Repair
Hemophilia with Hepatitis C and Recurrent Bleeding
Isotretinoin in Hemophilia
Laser Eye Surgery in a Hemophiliac
Managing Hemophilic Pseudotumors
Continuous NovoSeven: Pros and Cons
Complications of Treatment
Hemophilia B and Immune Tolerance with Anaphylaxis
NovoSeven (rFVIIa) and DIC
Thrombosis in Prothrombin Complex Concentrates (PCCs) vs
Activated Prothrombin Complex Concentrates (APCCs)
Von Willebrand Disease (VWD)
Epidurals and VWD
Anticoagulation for a Cardiac Valve in a patient with VWD type 1
VWD type 2a and Pregnancy
VWD type 2b and Pregnancy
VWD type 2b Versus Platelet Type
Prophylaxis in VWD type 3
Platelet Type VWD
Factor Deficiencies
Combined Factor V and VIII Deficiency
DVT Prophylaxis in FVII Deficiency
Menorrhagia in Factor VII Deficiency
Anticoagulation for Atrial Fibrillation in FX Deficiency
Management of Factor X Deficiency
Anticoagulation for Atrial Fibrillation in a patient with Factor XI Deficiency
Factor XI Deficiency and Surgery
Prophylaxis for Patients with Factor XIII Deficiency and Intracranial Bleeding
Rare Platelet and Coagulation Disorders
Coagulation Disorders 3
Dysfibrinogenemia
Hypofibrinogenemia
Gardner-Diamond Syndrome
Hereditary Hemorrhagic Telangiectasia (HHT)
Hereditary Vitamin K Dependent Coagulation Factors Deficiency and Pregnancy
Platelet Disorders
Glanzmann's Thrombasthenia and Gastrointestinal Angiodysplasia
Glanzmann's Thrombasthenia and Pregnancy
NovoSeven and Wiscott-Aldrich
Acquired Bleeding Diatheses
Acquired Hemophilia and Second Pregnancy
Developing a Factor IX Inhibitor
Acquired Bleeding Diatheses
End-Stage Liver Disease and Surgery
Treatment for Acute DIC
Miscellaneous Questions
Bleeding Time Versus PFA-100
Cocaine and DDAVP
Hyponatremia and DDAVP
The Use of the INR
Selective Serotonin Reuptake Inhibitors and Clotting Disturbances
Work-up for Children with Intracranial Bleeding
Thrombotic Disorders
Are Asians genetically different from Westerners when it comes to VTE?
Treatment of Antithrombin Deficiency
Anticardiolipin Antibody Questions
Pediatric Antiphospholipid Syndrome and Recurrent Thrombosis
Anticoagulation for Deep Venous Thrombosis in the Presence of an Intracranial Hemorrhage
Clinical Probability Assessment for Thromboembolic Disease
D-dimer in Thromboembolic Disease
Progestins and Thrombosis
Unknown Thrombophilia and Surgery
Table of Contents provided by Publisher. All Rights Reserved.

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Haemophilia and Haemostasis: A Case-Based Approach to Management

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