Handbook of Placental Pathology

A user-friendly text, this book explores all the diagnostic challenges pathologists and obstetricians will face. Succinct and accessible, the text includes discussions of lesions associated with maternal thrombophilias, updates in disorders with challenging clinicopathologic features and pathogenesis. The new edition contains updated sections on conditions such as preeclampsia and maternal diabetes mellitus, covers the use of technology such as molecular genetic probes and other newly developed ancillary studies to confirm diagnosis in problematic cases, and includes illustrations of umbilical cord, membranes, parenchymal and maternal surface abnormalities.

Preface to the Second Edition

vii

Preface to the First Edition

ix

Authors' acknowledgments

xi

Individual acknowledgments

xiii

Introduction

1

(2)

Development of the placenta

3

(4)

Structure of the placenta

7

(8)

Examination of the placenta in the clinical setting

15

(2)

Clinical data to be sent to the pathologist: how can the obstetrician ensure optimal/meaningful pathologic examination?

17

(4)

Indications for pathologic examination

21

(2)

Pathologic examination of the placenta: retention of the specimen and surgical pathology report

23

(4)

Gross abnormalities of the placenta: lesions due to disturbances of maternal and of fetal blood flow

27

(26)

Histologic lesions of the placenta: villi, fetal stem arteries, intervillous space and maternal arteries in decidua

53

(26)

Lesions of the placenta as a whole or of the placental disk

79

(46)

Lesions of the umbilical cord

125

(10)

Lesions of the membranes

135

(20)

Abnormalities of the decidua

155

(2)

Lesions of the placenta associated with pathologic maternal clinical presentations and/or underlying maternal disorders

157

(10)

Findings and lesions of the placenta reflecting fetal conditions

167

(26)

Iatrogenic lesions of the placenta, umbilical cord, and membranes

193

(2)

Traumatic lesions of the placenta

195

(2)

Placentas after assisted reproductive technologies

197

(2)

Placental features following intrauterine vascular laser ablation procedures

199

(4)

Final comment

203

(2)

Appendix

205

(4)

References

209

(24)

Index

233

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Handbook of Placental Pathology

Summary

Table of Contents

Supplemental Materials