Handbook of Synthetic Antioxidants

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ISBN: 9780824798109 | 0824798104
Cover: Hardcover
Copyright: 2/14/1997

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University of California, Berkeley. Provides a rationale for classification of synthetic antioxidants and thoroughly surveys each group. 28 contributors, 13 U.S. DNLM: Antioxidants - therapeutic use - handbooks.

Series Introduction

iii

(4)

Lester Packer

Jurgen Fuchs

Preface

vii

(6)

Contributors

xiii

Part I General Concepts

(52)

1. Approaches and Rationale for the Design of Synthetic Antioxidants as Therapeutic Agents

(52)

Craig E. Thomas

Part II Synthetic Derivatives of Natural Antioxidants

(124)

2. Design and Biological Evaluation of Tissue-Directed a-Tocopherol Analogs

(42)

Margaret A. Petty

Frank N. Bolkenius

James Dow

Gilbert Marciniak

3. Physical and Chemical Mechanisms of the Antioxidant Action of Tirilazad Mesylate

(44)

Dennis E. Epps

John M. McCall

4. Anionic Tocopherol Esters as Antioxidants and Cytoprotectants

139

(38)

Marc W. Fariss

Part III Phenolic Antioxidants

177

(84)

5. Phenolic Antioxidants: Physiological and Toxicological Aspects

177

(48)

Regine Kahl

6. Antioxidant Properties of Probucol

225

(16)

Etsuo Niki

Noriko Noguchi

7. Antioxidant Properties of the Catechol Derivative Nitecapone

241

(20)

Nobuya Haramaki

Lucia Marcocci

Teruyuki Kawabata

Lester Packer

Part IV 21-Aminosteroids or Lazaroids

261

(24)

8. Neuroprotective Efficacy and Mechanisms of the Lazaroids

261

(24)

Edward D. Hall

Part V Sulfhydryl- and Selenium-Containing Compounds

285

(54)

9. Antioxidant Properties of Ebselen

285

(20)

Noriko Noguchi

Etsuo Niki

10. The Development of Diaryl Chalcogenides and a-(Phenylselenenyl) Ketones with Antioxidant and Glutathione Peroxidase-Mimetic Properties

305

(16)

Ian A. Cotgreave

Lars Engman

11. Modulation of Glutathione

321

(18)

Mary E. Anderson

Part VI Nitrones and Nitroxides

339

(36)

12. Nitrone Radical Traps as Protectors of Oxidative Damage in the Central Nervous System

339

(12)

Robert A. Floyd

Guang-Jun Liu

Peter K. Wong

13. Antioxidant Properties of Nitroxides and Nitroxide SOD Mimics

351

(24)

Amram Samuni

Murali C. Krishna

Part VII SOD Mimics

375

(34)

14. Mimics of Superoxide Dismutase

375

(34)

Kevin M. Faulkner

Irwin Fridovich

Part VIII Metal Chelators

409

(28)

15. Antioxidant Properties of Synthetic Iron Chelators

409

(28)

Clifford S. Collis

Catherine A. Rice-Evans

Index

437

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Handbook of Synthetic Antioxidants

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Table of Contents

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