Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)

CONTRIBUTORSPREFACEPart 1: The Profession of Medicine 1 The Practice of MedicineThe Editors
2 Promoting Good HealthDonald M. Lloyd-Jones, Kathleen M. McKibbin
3 Decision-Making in Clinical MedicineDaniel B. Mark, John B. Wong
4 Screening and Prevention of DiseaseKatrina A. Armstrong, Gary J. Martin
5 Health Care Systems in Developed CountriesRichard B. Saltman
6 The Safety and Quality of Health CareDavid W. Bates
7 Racial and Ethnic Disparities in Health CareJoseph R. Betancourt, Alexander R. Green
8 Ethical Issues in Clinical MedicineBernard Lo, Christine Grady
9 Palliative and End-of-Life CareEzekiel J. Emanuel Part 2: Cardinal Manifestations and Presentation of Diseases Section 1: Pain 10 Pain: Pathophysiology and ManagementJames P. Rathmell, Howard L. Fields
11 Chest DiscomfortDavid A. Morrow
12 Abdominal PainDanny O. Jacobs
13 HeadachePeter J. Goadsby
14 Back and Neck PainJohn W. Engstrom Section 2: Alterations in Body Temperature 15 FeverCharles A. Dinarello, Reuven Porat
16 Fever and RashElaine T. Kaye, Kenneth M. Kaye
17 Fever of Unknown OriginChantal P. Bleeker-Rovers, Jos W. M. van der Meer Section 3: Nervous System Dysfunction 18 SyncopeRoy Freeman
19 Dizziness and VertigoMark F. Walker, Robert B. Daroff
20 FatigueJeffrey M. Gelfand, Vanja C. Douglas
21 Neurologic Causes of ?Weakness and ParalysisMichael J. Aminoff
22 Numbness, Tingling, and Sensory LossMichael J. Aminoff
23 Gait Disorders, Imbalance and FallsJessica M. Baker, Lewis R. Sudarsky
24 Confusion and DeliriumS. Andrew Josephson, Bruce L. Miller
25 DementiaWilliam W. Seeley, Bruce L. Miller
26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral DisordersM.-Marsel Mesulam
27 Sleep DisordersThomas E. Scammell, Clifford B. Saper, Charles A. Czeisler Section 4: Disorders of Eyes, Ears, Nose, and Throat 28 Disorders of the EyeJonathan C. Horton
29 Disorders of Smell and TasteRichard L. Doty, Steven M. Bromley
30 Disorders of HearingAnil K. Lalwani
31 Sore Throat, Earache, and Upper Respiratory SymptomsMichael A. Rubin, Larry C. Ford, Ralph Gonzales
32 Oral Manifestations of DiseaseSamuel C. Durso Section 5: Alterations in Circulatory and Respiratory Functions 33 DyspneaRebecca M. Baron
34 Cough Christopher H. Fanta
35 HemoptysisAnna K. Brady, Patricia A. Kritek
36 Hypoxia and CyanosisJoseph Loscalzo
37 EdemaEugene Braunwald, Joseph Loscalzo
38 Approach to the Patient with a Heart MurmurPatrick T. O’Gara, Joseph Loscalzo
39 PalpitationsJoseph Loscalzo Section 6: Alterations in Gastrointestinal Function 40 DysphagiaIkuo Hirano, Peter J. Kahrilas
41 Nausea, Vomiting, and IndigestionWilliam L. Hasler
42 Diarrhea and ConstipationMichael Camilleri, Joseph A. Murray
43 Unintentional Weight LossJ. Larry Jameson
44 Gastrointestinal BleedingLoren Laine
45 JaundiceSavio John, Daniel S. Pratt
46 Abdominal Swelling and AscitesKathleen E. Corey, Lawrence S. Friedman Section 7: Alterations in Renal and Urinary Tract Function 47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain SyndromeJohn W. Warren
48 Azotemia and Urinary AbnormalitiesDavid B. Mount
49 Fluid and Electrolyte DisturbancesDavid B. Mount
50 Hypercalcemia and HypocalcemiaSundeep Khosla
51 Acidosis and AlkalosisThomas D. DuBose, Jr. Section 8: Alterations in the Skin 52 Approach to the Patient with a Skin DisorderKim B. Yancey, Thomas J. Lawley
53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin DisordersLeslie P. Lawley, Calvin O. McCall, Thomas J. Lawley
54 Skin Manifestations of Internal DiseaseJean L. Bolognia, Irwin M. Braverman
55 Immunologically Mediated Skin DiseasesKim B. Yancey, Thomas J. Lawley
56 Cutaneous Drug ReactionsRobert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai
57 Photosensitivity and Other Reactions to LightAlexander G. Marneros, David R. Bickers Section 9: Hematologic Alterations 58 Interpreting Peripheral Blood Smears Dan L. Longo
59 Anemia and PolycythemiaJohn W. Adamson, Dan L. Longo
60 Disorders of Granulocytes and MonocytesSteven M. Holland, John I. Gallin
61 Bleeding and ThrombosisBarbara A. Konkle
62 Enlargement of Lymph Nodes and SpleenDan L. Longo Part 3: Pharmacology 63 Principles of Clinical PharmacologyDan M. Roden
64 PharmacogenomicsDan M. Roden Part 4: Oncology and Hematology Section 1: Neoplastic Disorders 65 Approach to the Patient with CancerDan L. Longo
66 Prevention and Early Detection of ?CancerJennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer
67 Cancer GeneticsFred Bunz, Bert Vogelstein
68 Cancer Cell BiologyJeffrey W. Clark, Dan L. Longo
69 Principles of Cancer TreatmentEdward A. Sausville, Dan L. Longo
70 Infections in Patients with CancerRobert W. Finberg
71 Oncologic EmergenciesRasim Gucalp, Janice P. Dutcher
72 Cancer of the SkinBrendan D. Curti, Sancy Leachman, Walter J. Urba 
73 Head and Neck CancerEverett E. Vokes
74 Neoplasms of the LungLeora Horn, Christine M. Lovly
75 Breast CancerDaniel F. Hayes, Marc E. Lippman
76 Upper Gastrointestinal Tract CancersRobert J. Mayer
77 Lower Gastrointestinal CancersRobert J. Mayer
78 Tumors of the Liver and Biliary TreeJosep M. Llovet
79 Pancreatic CancerDaniel D. Von Hoff
80 Neuroendocrine Tumors of the Gastrointestinal Tract and PancreasRobert T. Jensen
81 Renal Cell CarcinomaRobert J. Motzer
82 Cancer of the Bladder and Urinary TractNoah M. Hahn
83 Benign and Malignant Diseases of the ProstateHoward I. Scher, James A. Eastham
84 Testicular CancerDavid J. Vaughn
85 Gynecologic MalignanciesDavid Spriggs
86 Primary and Metastatic Tumors of the Nervous SystemLisa M. DeAngelis, Patrick Y. Wen
87 Soft Tissue and Bone Sarcomas and Bone MetastasesShreyaskumar R. Patel
88 Carcinoma of Unknown PrimaryGauri R. Varadhachary, James L. Abbruzzese
89 Paraneoplastic Syndromes: Endocrinologic/HematologicJ. Larry Jameson, Dan L. Longo
90 Paraneoplastic Neurologic Syndromes and Autoimmune EncephalitisJosep Dalmau, Myrna R. Rosenfeld
91 Late Consequences of Cancer and Its TreatmentCarl E. Freter, Dan L. Longo Section 2: Hematopoietic Disorders 92 Hematopoietic Stem CellsDavid T. Scadden, Dan L. Longo
93 Iron Deficiency and Other Hypoproliferative AnemiasJohn W. Adamson
94 Disorders of HemoglobinEdward J. Benz, Jr.
95 Megaloblastic AnemiasA. Victor Hoffbrand
96 Hemolytic Anemias Lucio Luzzatto
97 Anemia Due to Acute Blood LossDan L. Longo
98 Bone Marrow Failure Syndromes Including Aplastic Anemia and MyelodysplasiaNeal S. Young
99 Polycythemia Vera and Other Myeloproliferative NeoplasmsJerry L. Spivak
100 Acute Myeloid LeukemiaWilliam Blum, Clara D. Bloomfield
101 Chronic Myeloid LeukemiaHagop Kantarjian, Jorge Cortes
102 Acute Lymphoid LeukemiaDieter Hoelzer 
103 Chronic Lymphocytic LeukemiaJennifer A. Woyach, John C. Byrd
104 Non-Hodgkin’s LymphomaCaron A. Jacobson, Dan L. Longo
105 Hodgkin's Lymphoma Caron A. Jacobson, Dan L. Longo
106 Less Common Hematologic MalignanciesAyalew Tefferi, Dan L. Longo
107 Plasma Cell DisordersNikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson
108 AmyloidosisJohn L. Berk, Vaishali Sanchorawala 
109 Transfusion Biology and TherapyJeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson
110 Hematopoietic Cell TransplantationFrederick R. Appelbaum Section 3: Disorders of Hemostasis 111 Disorders of Platelets and Vessel WallBarbara A. Konkle
112 Coagulation DisordersValder R. Arruda, Katherine A. High
113 Arterial and Venous ThrombosisJane E. Freedman, Joseph Loscalzo
114 Antiplatelet, Anticoagulant, and Fibrinolytic DrugsJeffrey I. Weitz Part 5: Infectious Diseases Section 1: Basic Considerations in Infectious Diseases 115 Approach to the Patient with an Infectious DiseaseNeeraj K. Surana, Dennis L. Kasper
116 Molecular Mechanisms of Microbial PathogenesisGerald B. Pier
117 Approach to the Acutely Ill Infected Febrile PatientTamar F. Barlam, Dennis L. Kasper
118 Immunization Principles and Vaccine UseNancy Messonnier, Anne Schuchat, Lisa A. Jackson
119 Health Recommendations for International TravelJay S. Keystone, Phyllis E. Kozarsky
120 Climate Change and Infectious DiseaseAaron S. Bernstein Section 2: Clinical Syndromes: Community-Acquired Infections 121 PneumoniaLionel A. Mandell, Richard G. Wunderink
122 Lung AbscessRebecca M. Baron, Miriam Baron Barshak
123 Infective EndocarditisAdolf W. Karchmer
124 Infections of the Skin, Muscles, and Soft TissuesDennis L. Stevens
125 Infectious ArthritisLawrence C. Madoff
126 OsteomyelitisWerner Zimmerli
127 Intraabdominal Infections and AbscessesMiriam Baron Barshak, Dennis L. Kasper
128 Acute Infectious Diarrheal Diseases and Bacterial Food PoisoningRichelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque
129 Clostridium difficile Infection, Including Pseudomembranous ColitisDale N. Gerding, Stuart Johnson
130 Urinary Tract Infections, Pyelonephritis, and ProstatitisKalpana Gupta, Barbara W. Trautner
131 Sexually Transmitted Infections: Overview and Clinical ApproachJeanne M. Marrazzo, King K. Holmes
132 EncephalitisKaren L. Roos, Kenneth L. Tyler
133 Acute MeningitisKaren L. Roos, Kenneth L. Tyler
134 Chronic and Recurrent MeningitisWalter J. Koroshetz, Michael R. Wilson, Avindra Nath
135 Brain Abscess and EmpyemaKaren L. Roos, Kenneth L. Tyler
136 Infectious Complications of BitesSandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff Section 3: Clinical Syndromes: Health Care-Associated Infections 137 Infections Acquired in Health Care FacilitiesRobert A. Weinstein
138 Infections in Transplant RecipientsRobert W. Finberg, Joyce D. Fingeroth Section 4: Therapy for Bacterial Diseases 139 Treatment and Prophylaxis of Bacterial InfectionsDavid C. Hooper, Erica S. Shenoy, Christy A. Varughese
140 Bacterial Resistance to Antimicrobial AgentsDavid C. Hooper Section 5: Diseases Caused by Gram-Positive Bacteria 141 Pneumococcal InfectionsDavid Goldblatt, Katherine L. O’Brien
142 Staphylococcal InfectionsFranklin D. Lowy
143 Streptococcal InfectionsMichael R. Wessels
144 Enterococcal InfectionsCesar A. Arias, Barbara E. Murray
145 Diphtheria and Other Corynebacterial InfectionsWilliam R. Bishai, John R. Murphy
146 Listeria monocytogenes InfectionsElizabeth L. Hohmann, Daniel A. Portnoy
147 TetanusC. Louise Thwaites, Lam Minh Yen
148 BotulismAgam K. Rao, Susan Maslanka
149 Gas Gangrene and Other Clostridial InfectionsAmy E. Bryant, Dennis L. Stevens Section 6: Diseases Caused by Gram-Negative Bacteria 150 Meningococcal InfectionsAndrew J. Pollard 
151 Gonococcal InfectionsSanjay Ram, Peter A. Rice
152 Haemophilus and Moraxella InfectionsTimothy F. Murphy
153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative BacteriaTamar F. Barlam, Dennis L. Kasper
154 Legionella InfectionsVictor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin
155 Pertussis and Other Bordetella InfectionsKarina A. Top, Scott A. Halperin
156 Diseases Caused by Gram-Negative Enteric BacilliThomas A. Russo, James R. Johnson
157 Acinetobacter InfectionsRossana Rosa, L. Silvia Munoz-Price
158 Helicobacter pylori InfectionsJohn C. Atherton, Martin J. Blaser
159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas SpeciesReuben Ramphal
160 SalmonellosisDavid A. Pegues, Samuel I. Miller
161 ShigellosisPhilippe J. Sansonetti, Jean Bergounioux
162 Infections Due to Campylobacter and Related OrganismsBeth D. Kirkpatrick, Martin J. Blaser
163 Cholera and Other VibriosesMatthew K. Waldor, Edward T. Ryan 
164 BrucellosisNicholas J. Beeching
165 TularemiaJeannine M. Petersen, Paul S. Mead
166 Plague and Other Yersinia InfectionsMichael B. Prentice
167 Bartonella Infections, Including Cat-Scratch DiseaseMichael Giladi, Moshe Ephros
168 DonovanosisNigel O’Farrell Section 7: Miscellaneous Bacterial Infections 169 NocardiosisGregory A. Filice
170 Actinomycosis Thomas A. Russo
171 Whipple’s DiseaseThomas A. Russo
172 Infections Due to Mixed Anaerobic OrganismsNeeraj K. Surana, Dennis L. Kasper Section 8: Mycobacterial Diseases 173 TuberculosisMario C. Raviglione
174 LeprosyRobert H. Gelber
175 Nontuberculous Mycobacterial InfectionsSteven M. Holland
176 Antimycobacterial AgentsDivya Reddy, Max R. O’Donnell Section 9: Spirochetal Diseases 177 SyphilisSheila A. Lukehart
178 Endemic TreponematosesSheila A. Lukehart
179 LeptospirosisJiri F. P. Wagenaar, Marga G. A. Goris
180 Relapsing FeverAlan G. Barbour
181 Lyme BorreliosisAllen C. Steere Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae 182 Rickettsial DiseasesDavid H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie
183 Infections Due to MycoplasmasR. Doug Hardy
184 Chlamydial InfectionsCharlotte A. Gaydos, Thomas C. Quinn Section 11: Viral Diseases: General Considerations 185 Medical VirologyFred Wang, Elliott Kieff
186 Antiviral Chemotherapy, Excluding Antiretroviral DrugsLindsey R. Baden Section 12: Infections Due to DNA Viruses 187 Herpes Simplex Virus InfectionsLawrence Corey
188 Varicella-Zoster Virus InfectionsRichard J. Whitley
189 Epstein-Barr Virus Infections, Including Infectious MononucleosisJeffrey I. Cohen
190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8Camille Nelson Kotton, Martin S. Hirsch
191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus InfectionsFred Wang
192 Parvovirus InfectionsKevin E. Brown
193 Human Papillomavirus InfectionsDarron R. Brown, Aaron Ermel Section 13: Infections Due to DNA and RNA Respiratory Viruses 194 Common Viral Respiratory Infections James E. Crowe, Jr.
195 InfluenzaPeter F. Wright Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses 196 The Human RetrovirusesDan L. Longo, Anthony S. Fauci
197 Human Immunodeficiency Virus Disease: AIDS and Related DisordersAnthony S. Fauci, Gregory K. Folkers, H. Clifford Lane Section 15: Infections Due to RNA Viruses 198 Viral GastroenteritisUmesh D. Parashar, Roger I. Glass
199 Enterovirus, Parechovirus, and Reovirus InfectionsJeffrey I. Cohen
200 Measles (Rubeola)Kaitlin Rainwater-Lovett, William J. Moss
201 Rubella (German Measles)Laura A. Zimmerman, Susan E. Reef
202 MumpsSteven A. Rubin
203 Rabies and Other Rhabdovirus InfectionsAlan C. Jackson
204 Arthropod-Borne and Rodent-Borne Virus InfectionsJens H. Kuhn, Rémi N. Charrel
205 Ebolavirus and Marburgvirus InfectionsJens H. Kuhn Section 16: Fungal Infections 206 Diagnosis and Treatment of Fungal InfectionsJohn E. Edwards, Jr. 
207 HistoplasmosisChadi A. Hage, L. Joseph Wheat
208 CoccidioidomycosisNeil M. Ampel
209 BlastomycosisS. Travis King, Rathel L. Nolan, III 
210 CryptococcosisArturo Casadevall
211 CandidiasisJohn E. Edwards, Jr.
212 AspergillosisDavid W. Denning
213 MucormycosisBrad Spellberg, Ashraf S. Ibrahim
214 Superficial Mycoses and Less Common Systemic MycosesCarol A. Kauffman
215 Pneumocystis InfectionsAlison Morris, Henry Masur Section 17: Protozoal and Helminthic Infections: General Considerations 216 Introduction to Parasitic Infections Sharon L. Reed, Charles E. Davis
217 Agents Used to Treat Parasitic InfectionsThomas A. Moore Section 18: Protozoal Infections 218 Amebiasis and Infection with Free-Living AmebaeRosa M. Andrade, Sharon L. Reed
219 MalariaNicholas J. White, Elizabeth A. Ashley
220 BabesiosisEdouard Vannier, Peter J. Krause
221 LeishmaniasisShyam Sundar
222 Chagas Disease and African TrypanosomiasisFrançois Chappuis, Yves Jackson
223 Toxoplasma InfectionsKami Kim
224 Protozoal Intestinal Infections and TrichomoniasisPeter F. Weller Section 19: Helminthic Infections 225 Introduction to Helminthic InfectionsPeter F. Weller
226 Trichinellosis and Other Tissue Nematode InfectionsPeter F. Weller
227 Intestinal Nematode InfectionsPeter F. Weller, Thomas B. Nutman
228 Filarial and Related InfectionsThomas B. Nutman, Peter F. Weller
229 Schistosomiasis and Other Trematode InfectionsBirgitte Jyding Vennervald
230 Cestode InfectionsA. Clinton White, Jr., Peter F. Weller Part 6: Disorders of the Cardiovascular System Section 1: Introduction to Cardiovascular Disorders 231 Approach to the Patient with Possible Cardiovascular DiseaseJoseph Loscalzo
232 Basic Biology of the Cardiovascular SystemJoseph Loscalzo, Peter Libby, Calum A. MacRae
233 Epidemiology of Cardiovascular DiseaseThomas A. Gaziano, J. Michael Gaziano Section 2: Diagnosis of Cardiovascular Disorders 234 Physical Examination of the Cardiovascular SystemPatrick T. O’Gara, Joseph Loscalzo
235 ElectrocardiographyAry L. Goldberger
236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography ImagingMarcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 
237 Diagnostic Cardiac Catheterization and Coronary AngiographyJane A. Leopold, David P. Faxon Section 3: Disorders of Rhythm 238 Principles of ElectrophysiologyDavid D. Spragg, Gordon F. Tomaselli
239 The Bradyarrhythmias: Disorders of the Sinoatrial NodeDavid D. Spragg, Gordon F. Tomaselli
240 The Bradyarrhythmias: Disorders of the Atrioventricular NodeDavid D. Spragg, Gordon F. Tomaselli
241 Approach to Supraventricular TachyarrhythmiasGregory F. Michaud, William G. Stevenson
242 Physiologic and Non-physiologic Sinus Tachycardia Gregory F. Michaud, William G. Stevenson
243 Focal Atrial Tachycardia Gregory F. Michaud, William G. Stevenson
244 Paroxysmal Supraventricular TachycardiasGregory F. Michaud, William G. Stevenson
245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial TachycardiasGregory F. Michaud, William G. Stevenson
246 Atrial FibrillationGregory F. Michaud, William G. Stevenson
247 Approach to Ventricular Arrhythmias Roy M. John, William G. Stevenson
248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm Roy M. John, William G. Stevenson
249 Sustained Ventricular Tachycardia William G. Stevenson, Roy M. John
250 Polymorphic Ventricular Tachycardia and Ventricular FibrillationWilliam G. Stevenson, Roy M. John
251 Electrical Storm and Incessant VTWilliam G. Stevenson, Roy M. John Section 4: Disorders of the Heart 252 Heart Failure: Pathophysiology and DiagnosisDouglas L. Mann, Murali Chakinala
253 Heart Failure: ManagementMandeep R. Mehra 
254 Cardiomyopathy and MyocarditisNeal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo
255 Cardiac Transplantation and Prolonged Assisted Circulation Mandeep R. Mehra
256 Aortic Valve ?DiseasePatrick T. O’Gara, Joseph Loscalzo
257 Aortic Regurgitation Patrick T. O’Gara, Joseph Loscalzo
258 Mitral StenosisPatrick T. O’Gara, Joseph Loscalzo
259 Mitral RegurgitationPatrick T. O’Gara, Joseph Loscalzo
260 Mitral Valve ProlapsePatrick T. O’Gara, Joseph Loscalzo
261 Tricuspid Valve DiseasePatrick T. O’Gara, Joseph Loscalzo
262 Pulmonic Valve DiseasePatrick T. O’Gara, Joseph Loscalzo
263 Multiple and Mixed Valvular Heart DiseasePatrick T. O’Gara, Joseph Loscalzo
264 Congenital Heart Disease in the AdultAnne Marie Valente, Michael J. Landzberg
265 Pericardial DiseaseEugene Braunwald
266 Atrial Myxoma and Other Cardiac TumorsEric H. Awtry Section 5: Coronary and Peripheral Vascular Disease 267 Ischemic Heart DiseaseElliott Antman, Joseph Loscalzo
268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald
269 ST-Segment Elevation Myocardial InfarctionElliott M. Antman, Joseph Loscalzo
270 Percutaneous Coronary Interventions and Other Interventional ProceduresDavid P. Faxon, Deepak L. Bhatt
271 Hypertensive Vascular DiseaseTheodore A. Kotchen
272 Renovascular DiseaseStephen C. Textor
273 Deep Venous Thrombosis and Pulmonary ThromboembolismSamuel Z. Goldhaber
274 Diseases of the AortaMark A. Creager, Joseph Loscalzo
275 Arterial Diseases of the ExtremitiesMark A. Creager, Joseph Loscalzo
276 Chronic Venous Disease and Lymphedema Mark A. Creager, Joseph Loscalzo
277 Pulmonary HypertensionAaron B. Waxman, Joseph Loscalzo Part 7: Disorders of the Respiratory System Section 1: Diagnosis of Respiratory Disorders 278 Approach to the Patient with Disease of the Respiratory SystemPatricia A. Kritek, Bruce D. Levy
279 Disturbances of Respiratory FunctionEdward T. Naureckas, Julian Solway 
280 Diagnostic Procedures in Respiratory DiseaseAnne L. Fuhlbrigge, Augustine M.K. Choi  Section 2: Diseases of the Respiratory System 281 AsthmaPeter J. Barnes
282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with EosinophiliaPraveen Akuthota, Michael E. Wechsler
283 Occupational and Environmental Lung DiseaseJohn R. Balmes
284 BronchiectasisRebecca M. Baron, Miriam Baron Barshak
285 Cystic FibrosisEric J. Sorscher
286 Chronic Obstructive Pulmonary DiseaseEdwin K. Silverman, James D. Crapo, Barry Make
287 Interstitial Lung DiseaseGary M. Hunninghake, Ivan O. Rosas
288 Disorders of the PleuraRichard W. Light
289 Disorders of the MediastinumRichard W. Light
290 Disorders of Ventilation John F. McConville, Julian Solway, Babak Mokhlesi 
291 Sleep ApneaAndrew Wellman, Susan Redline
292 Lung TransplantationElbert P. Trulock, III Part 8: Critical Care Medicine Section 1: Respiratory Critical Care 293 Approach to the Patient with Critical IllnessJohn P. Kress, Jesse B. Hall
294 Acute Respiratory Distress SyndromeRebecca M. Baron, Bruce D. Levy
295 Mechanical Ventilatory SupportBartolome R. Celli Section 2: Shock and Cardiac Arrest 296 Approach to the Patient with ShockAnthony F. Massaro
297 Sepsis and Septic ShockChristopher W. Seymour, Derek C. Angus
298 Cardiogenic Shock and Pulmonary EdemaDavid H. Ingbar, Holger Thiele
299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Christine M. Albert, William G. Stevenson  Section 3: Neurologic Critical Care 300 ComaS. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 
301 Severe Acute Encephalopathies and Critical Care WeaknessJ. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress
302 Subarachnoid HemorrhageJ. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress Part 9: Disorders of the Kidney and Urinary Tract 303 Cellular and Molecular Biology of the KidneyAlfred L. George, Jr., Eric G. Neilson
304 Acute Kidney InjurySushrut S. Waikar, Joseph V. Bonventre
305 Chronic Kidney Disease Joanne M. Bargman, Karl L. Skorecki
306 Dialysis in the Treatment of Renal FailureKathleen D. Liu, Glenn M. Chertow
307 Transplantation in the Treatment of Renal FailureJamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 
308 Glomerular DiseasesJulia B. Lewis, Eric G. Neilson
309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and DevelopmentJing Zhou, Martin R.  Pollak
310 Tubulointerstitial Diseases of the KidneyLaurence H. Beck, Jr., David J. Salant
311 Vascular Injury to the KidneyRonald S. Go, Nelson Leung
312 NephrolithiasisGary C. Curhan
313 Urinary Tract ObstructionJulian L. Seifter Part 10: Disorders of the Gastrointestinal System Section 1: Disorders of the Alimentary Tract 314 Approach to the Patient with Gastrointestinal DiseaseWilliam L. Hasler, Chung Owyang
315 Gastrointestinal EndoscopyLouis Michel Wong Kee Song, Mark Topazian
316 Diseases of the EsophagusPeter J. Kahrilas, Ikuo Hirano
317 Peptic Ulcer Disease and Related DisordersJohn Del Valle
318 Disorders of AbsorptionHenry J. Binder
319 Inflammatory Bowel DiseaseSonia Friedman, Richard S. Blumberg
320 Irritable Bowel SyndromeChung Owyang
321 Diverticular Disease and Common Anorectal DisordersRizwan Ahmed, Susan L. Gearhart
322 Mesenteric Vascular InsufficiencySatinderjit Locham, Mahmoud Malas
323 Acute Intestinal ObstructionDanny O. Jacobs
324 Acute Appendicitis and PeritonitisDanny O. Jacobs Section 2: Nutrition  325 Nutrient Requirements and Dietary AssessmentJohanna Dwyer
326 Vitamin and Trace Mineral Deficiency and ExcessPaolo M. Suter, Robert M. Russell
327 Malnutrition and Nutritional Assessment Gordon L. Jensen
328 Enteral and Parenteral NutritionL. John Hoffer, Bruce R. Bistrian, David F. Driscoll Section 3: Liver and Biliary Tract Disease 329 Approach to the Patient with Liver DiseaseMarc G. Ghany, Jay H. Hoofnagle 
330 Evaluation of Liver FunctionDaniel S. Pratt
331 The HyperbilirubinemiasAllan W. Wolkoff
332 Acute Viral HepatitisJules L. Dienstag
333 Toxic and Drug-Induced HepatitisWilliam M. Lee, Jules L. Dienstag
334 Chronic HepatitisJules L. Dienstag
335 Alcoholic Liver DiseaseMark E. Mailliard, Michael F. Sorrell
336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic SteatohepatitisManal F. Abdelmalek, Anna Mae Diehl
337 Cirrhosis and Its ComplicationsBruce R. Bacon
338 Liver TransplantationRaymond T. Chung, Jules L. Dienstag
339 Diseases of the Gallbladder and Bile DuctsNorton J. Greenberger, Gustav Paumgartner Section 4: Disorders of the Pancreas 340 Approach to the Patient with Pancreatic DiseaseDarwin L. Conwell, Norton J. Greenberger, Peter A. Banks
341 Acute and Chronic PancreatitisDarwin L. Conwell, Peter A. Banks, Norton J. Greenberger Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders Section 1: The Immune System in Health and Disease 342 Introduction to the Immune SystemBarton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci
343 The Major Histocompatibility ComplexGerald T. Nepom
344 Primary Immune Deficiency DiseasesAlain Fischer Section 2: Disorders of Immune-Mediated Injury 345 Urticaria, Angioedema, and Allergic Rhinitis Katherine N. Cahill, Joshua A. Boyce
346 AnaphylaxisDavid Hong, Joshua A. Boyce
347 MastocytosisCem Akin, Joshua A. Boyce
348 Autoimmunity and Autoimmune DiseasesBetty Diamond, Peter E. Lipsky
349 Systemic Lupus ErythematosusBevra Hannahs Hahn
350 Antiphospholipid SyndromeHaralampos M. Moutsopoulos
351 Rheumatoid ArthritisAnkoor Shah, E. William St. Clair
352 Acute Rheumatic FeverJonathan R. Carapetis
353 Systemic Sclerosis (Scleroderma) and Related DisordersJohn Varga
354 Sjögren’s SyndromeHaralampos M. Moutsopoulos
355 The SpondyloarthritidesJoel D. Taurog
356 The Vasculitis SyndromesCarol A. Langford, Anthony S. Fauci
357 Behçet’s SyndromeHaralampos M. Moutsopoulos
358 Inflammatory MyopathiesSteven A. Greenberg, Anthony A. Amato
359 Relapsing PolychondritisCarol A. Langford
360 SarcoidosisRobert P. Baughman, Elyse E. Lower
361 IgG4-Related DiseaseJohn H. Stone
362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory DiseasesDaniel L. Kastner Section 3: Disorders of the Joints and Adjacent Tissues 363 Approach to Articular and Musculoskeletal DisordersJohn J. Cush
364 OsteoarthritisDavid T. Felson, Tuhina Neogi
365 Gout and Other Crystal-Associated ArthropathiesH. Ralph Schumacher, Lan X. Chen
366 FibromyalgiaLeslie J. Crofford
367 Arthritis Associated with Systemic Disease, and Other ArthritidesCarol A. Langford, Brian F. Mandell 
368 Periarticular Disorders of the ExtremitiesCarol A. Langford Part 12: Endocrinology and Metabolism Section 1: Endocrinology 369 Approach to the Patient with Endocrine DisordersJ. Larry Jameson
370 Mechanisms of Hormone ActionJ. Larry Jameson
371 Physiology of Anterior Pituitary HormonesShlomo Melmed, J. Larry Jameson
372 HypopituitarismShlomo Melmed, J. Larry Jameson
373 Pituitary Tumor SyndromesShlomo Melmed, J. Larry Jameson
374 Disorders of the NeurohypophysisGary L. Robertson
375 Thyroid Gland Physiology and TestingJ. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
376 HypothyroidismJ. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
377 HyperthyroidismJ. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
378 Thyroid Nodular Disease and Thyroid CancerJ. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
379 Disorders of the Adrenal CortexWiebke Arlt
380 PheochromocytomaHartmut P. H. Neumann
381 Multiple Endocrine NeoplasiaR. V. Thakker
382 Autoimmune Polyendocrine SyndromesPeter A. Gottlieb, Aaron W. Michels Section 2: Sex- and Gender-Based Medicine 383 Disorders of Sex DevelopmentJohn C. Achermann, J. Larry Jameson
384 Disorders of the Testes and Male Reproductive SystemShalender Bhasin, J. Larry Jameson
385 Disorders of the Female Reproductive SystemJanet E. Hall
386 Menstrual Disorders and Pelvic PainJanet E. Hall
387 HirsutismDavid A. Ehrmann
388 Menopause and Postmenopausal Hormone TherapyJoAnn E. Manson, Shari S. Bassuk
389 Infertility and ContraceptionJanet E. Hall
390 Sexual DysfunctionKevin T. McVary
391 Women’s HealthAndrea Dunaif
392 Men’s HealthShalender Bhasin, Shehzad Basaria
393 Lesbian, Gay, Bisexual, and Transgender (LGBT) HealthBaligh R. Yehia, Harvey J. Makadon Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome 394 Pathobiology of Obesity Jeffrey S. Flier, Eleftheria Maratos-Flier
395 Evaluation and Management of ObesityRobert F. Kushner
396 Diabetes Mellitus: Diagnosis, Classification, and PathophysiologyAlvin C. Powers, Kevin D. Niswender, Carmella Evans-Molina
397 Diabetes Mellitus: Management and TherapiesAlvin C. Powers, Kevin D. Niswender, Michael R. Rickels
398 Diabetes Mellitus: ComplicationsAlvin C. Powers, John M. Stafford, Michael R. Rickels
399 HypoglycemiaPhilip E. Cryer, Stephen N. Davis
400 Disorders of Lipoprotein MetabolismDaniel J. Rader, Sekar Kathiresan
401 The Metabolic SyndromeRobert H. Eckel Section 4: Disorders of Bone and Mineral Metabolism 402 Bone and Mineral Metabolism in Health and DiseaseF. Richard Bringhurst, Marie B. Demay, Henry M. Kronenberg
403 Disorders of the Parathyroid Gland and Calcium HomeostasisJohn T. Potts, Jr., Harald Jüppner
404 OsteoporosisRobert Lindsay, Felicia Cosman
405 Paget’s Disease and Other Dysplasias of BoneMurray J. Favus, Tamara J. Vokes Section 5: Disorders of Intermediary Metabolism 406 Heritable Disorders of Connective TissueDarwin J. Prockop, John F. Bateman
407 HemochromatosisLawrie W. Powell
408 Wilson’s DiseaseGeorge J. Brewer
409 The PorphyriasRobert J. Desnick, Manisha Balwani
410 Disorders of Purine and Pyrimidine MetabolismJohn N. Mecchella, Christopher M. Burns
411 Lysosomal Storage DiseasesRobert J. Hopkin, Gregory A. Grabowski
412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate MetabolismPriya S. Kishnani, Yuan-Tsong Chen
413 Inherited Disorders of Amino Acid Metabolism in AdultsNicola Longo
414 Inherited Defects of Membrane TransportNicola Longo Part 13: Neurologic Disorders Section 1: Diagnosis of Neurologic Disorders 415 Approach to the Patient with Neurologic DiseaseDaniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser
416 Neuroimaging in Neurologic DisordersWilliam P. Dillon
417 Pathobiology of Neurologic DiseasesStephen L. Hauser, Arnold R. Kriegstein, Stanley B. Prusiner Section 2: Diseases of the Central Nervous System 418 Seizures and EpilepsyDaniel H. Lowenstein
419 Cerebrovascular DiseasesWade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
420 Ischemic Stroke Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
421 Intracranial Hemorrhage Wade S. Smith, J. Claude Hemphill, III, S. Claiborne Johnston
422 Migraine and Other Primary Headache DisordersPeter J. Goadsby
423 Alzheimer’s Disease William W. Seeley, Bruce L. Miller
424 Frontotemporal DementiaWilliam W. Seeley, Bruce L. Miller
425 Vascular DementiaJoel H. Kramer, William W. Seeley, Bruce L. Miller
426 Dementia with Lewy Bodies William W. Seeley, Caroline M. Tanner, Bruce L. Miller
427 Parkinson’s Disease C. Warren Olanow, Christine Klein, Anthony H. V. Schapira
428 Tremor, Chorea, and Other Movement DisordersC. Warren Olanow, Christine Klein, Jose A. Obeso
429 Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesRobert H. Brown, Jr.
430 Prion DiseasesStanley B. Prusiner, Bruce L. Miller
431 Ataxic DisordersRoger N. Rosenberg
432 Disorders of the Autonomic Nervous SystemChristopher H. Gibbons, John W. Engstrom
433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve DisordersM. Flint Beal, Stephen L. Hauser
434 Diseases of the Spinal CordStephen L. Hauser
435 Concussion and Other Traumatic Brain InjuriesGeoffrey T. Manley, Stephen L. Hauser, Michael McCrea
436 Multiple Sclerosis Bruce A. C. Cree, Stephen L. Hauser
437 Neuromyelitis OpticaBruce A. C. Cree, Stephen L. Hauser Section 3: Nerve and Muscle Disorders 438 Peripheral NeuropathyAnthony A. Amato, Richard J. Barohn
439 Guillain-Barré Syndrome and Other Immune-Mediated NeuropathiesStephen L. Hauser, Anthony A. Amato
440 Myasthenia Gravis and Other Diseases of the Neuromuscular JunctionAnthony A. Amato
441 Muscular Dystrophies and Other Muscle DiseasesAnthony A. Amato, Robert H. Brown, Jr. Section 4: Chronic Fatigue Syndrome 442 Chronic Fatigue SyndromeGijs Bleijenberg, Jos W. M. van der Meer Section 5: Psychiatric and Addiction Disorders 443 Biology of Psychiatric DisordersRobert O. Messing, Eric J. Nestler, Matthew W. State
444 Psychiatric DisordersVictor I. Reus
445 Alcohol and Alcohol Use DisordersMarc A. Schuckit
446 Opioid-Related DisordersThomas R. Kosten, Colin N. Haile
447 Cocaine and Other Commonly Used DrugsKarran A. Phillips, Antonello Bonci
448 Nicotine AddictionDavid M. Burns Part 14: Poisoning, Drug Overdose, and Envenomation 449 Heavy Metal PoisoningHoward Hu
450 Poisoning and Drug OverdoseMark B. Mycyk
451 Disorders Caused by Venomous Snakebites and Marine Animal ExposuresCharles Lei, Kirsten B. Hornbeak, Paul S. Auerbach, Robert L. Norris
452 Ectoparasite Infestations and Arthropod InjuriesRichard J. Pollack, Scott A. Norton Part 15: Disorders Associated with Environmental Exposures 453 Altitude IllnessBuddha Basnyat, Geoffrey Tabin
454 Hypothermia and Peripheral Cold InjuriesDaniel F. Danzl
455 Heat-Related IllnessesDaniel F. Danzl Part 16: Genes, the Environment, and Disease 456 Principles of Human GeneticsJ. Larry Jameson, Peter Kopp
457 The Practice of Genetics in Clinical MedicineSusan M. Domchek, J. Larry Jameson, Susan Miesfeldt
458 Gene and Cell Based Therapy in Clinical MedicineKatherine A. High, Malcolm K. Brenner
459 The Human MicrobiomeNeeraj K. Surana, Dennis L. Kasper Part 17: Global Medicine 460 Global Issues in MedicineJoseph J. Rhatigan, Paul Farmer
461 Worldwide Changes in Patterns of Infectious DiseaseGeorge W. Rutherford, Jaime Sepulveda
462 Primary Care and Global Health Tim Evans, Kumanan Rasanathan Part 18: Aging 463 The Biology of AgingRafael de Cabo, David G. Le Couteur
464 Clinical Problems Associated with the Aging ProcessJoseph G. Ouslander, Bernardo Reyes Part 19: Consultative Medicine 465 Approach to Medical ConsultationJack Ende, Jeffrey Berns
466 Medical Disorders During PregnancyRobert L. Barbieri, John T. Repke
467 Medical Evaluation of the Surgical PatientPrashant Vaishnava, Kim A. Eagle Part 20: Frontiers 468 Behavioral Economics and Health Kevin G. Volpp, George Loewenstein, David A. Asch
469 Complementary, Alternative, and Integrative Health ApproachesJosephine P. Briggs
470 Telomere DiseaseRodrigo T. Calado, Neal S. Young
471 The Role of Epigenetics in Disease and TreatmentBrian C. Capell, Shelley L. Berger
472 Mitochondrial DNA and Heritable Traits and DiseasesKarl L. Skorecki, Bruce H. Cohen
473 Applications of Stem Cell Biology in Clinical MedicineJohn A. Kessler
474 Microbial Genomics and Infectious DiseaseRoby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung
475 The Role of Circadian Biology in Health and DiseaseJonathan Cedernaes, Kathryn Moynihan Ramsey, Joseph Bass
476 Network Medicine: Systems Biology in Health and DiseaseJoseph Loscalzo
477 Emerging Neurotherapeutic TechnologiesJyoti Mishra, Karunesh Ganguly Online ChaptersThe following chapters are available online. They can be viewed at www.accessmedicine.com. Part 21: Video Collection V1 Video Library of Gait DisordersGail Kang, Nicholas B. Galifianakis, Michael D. Geschwind
V2 Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral DisordersMaria Luisa Gorno-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia
V3 Video Library of Neuro-OphthalmologyJonathan C. Horton
V4 Examination of the Comatose PatientS. Andrew Josephson
V5 Video Atlas of Gastrointestinal Endoscopic Lesions Louis Michel Wong Kee Song, Mark Topazian
V6 The Neurologic Screening ExamDaniel H. Lowenstein
V7 Video Atlas of the Detailed Neurologic ExaminationMartin A. Samuels
Part 22: Supplementary Topics S1 Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case ExamplesDavid B. Mount, Thomas D. DuBose, Jr.
S2 Microbial BioterrorismH. Clifford Lane, Anthony S. Fauci
S3 Chemical TerrorismJonathan Newmark, James A. Romano, Jr. 
S4 Radiation TerrorismChristine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner
S5 Infections in War Veterans Andrew W. Artenstein
S6 Health Care for Military VeteransStephen C. Hunt, Charles W. Hoge 
S7 Primary Immunodeficiencies Associated with (or Secondary to) Other DiseasesAlain Fischer
S8 Cardiac TraumaEric H. Awtry
S9 Technique of Lumbar PunctureElizabeth Robbins, Stephen L. Hauser
S10 Classification of the Spinocerebellar AtaxiasRoger N. Rosenberg
S11 Hyperbaric and Diving MedicineMichael H. Bennett, Simon J. Mitchell
S12 The Clinical Laboratory in Modern Health CareAnthony A. Killeen
S13 Laboratory Diagnosis of Infectious DiseasesAlexander J. McAdam, Andrew B. Onderdonk
S14 Laboratory Diagnosis of Parasitic InfectionsSharon L. Reed, Charles E. Davis Part 23: Atlases A1 Atlas of Rashes Associated with FeverKenneth M. Kaye, Elaine T. Kaye
A2 Atlas of Oral Manifestations of DiseaseSamuel C. Durso, Janet A. Yellowitz
A3 Atlas of Urinary Sediments and Renal BiopsiesAgnes B. Fogo, Eric G. Neilson
A4 Atlas of Skin Manifestations of Internal DiseaseThomas J. Lawley, Benjamin K. Stoff, Calvin O. McCall
A5 Atlas of HematologyDan L. Longo
A6 Atlas of Blood Smears of Malaria and BabesiosisNicholas J. White, Joel G. Breman
A7 Atlas of ElectrocardiographyAry L. Goldberger
A8 Atlas of Noninvasive ImagingMarcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 
A9 Atlas of Cardiac ArrhythmiasAry L. Goldberger
A10 Atlas of AtherosclerosisPeter Libby
A11 Atlas of Percutaneous RevascularizationJane A. Leopold, Deepak L. Bhatt, David P. Faxon
A12 Atlas of Chest ImagingPatricia A. Kritek, John J. Reilly, Jr.
A13 Atlas of Liver BiopsiesJules L. Dienstag, Atul K. Bhan
A14 Atlas of the Vasculitic SyndromesCarol A. Langford, Anthony S. Fauci
A15 Atlas of Clinical Manifestations of Metabolic DiseasesJ. Larry Jameson
A16 Atlas of NeuroimagingAndre D. Furtado, Luciano Villarinho, William P. Dillon 
IndexI-1