Helicobacter Pylori

Univ. of Maryland, Baltimore. Discusses important findings about the physiology and genetics of H. pylori, and also includes sections on epidemiology, bacteriology, bacterial virulence and pathogenic mechanisms, pathogenesis in the host, diagnosis and treatment, animal models, and other Helicobacter species.

Contributors

ix

Preface

xv

Acknowledgments

xvii

I. Introduction

Overview

3

(4)

Harry L. T. Mobley

George L. Mendz

Stuart L. Hazell

Epidemiology of Infection

7

(12)

Hazel M. Mitchell

One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and Its Association with Peptic Ulcer Disease

19

(8)

Barry J. Marshall

II. Bacteriology

Basic Bacteriology and Culture

27

(12)

Lief Percival Andersen

Torkel Wadstrom

Taxonomy of the Helicobacter Genus

39

(14)

Jay V. Solnick

Peter Vandamme

Morphology and Ultrastructure

53

(16)

Jani O'Rourke

Gunter Bode

Cell Envelope

69

(12)

Paul W. O'Toole

Marguerite Clyne

Molecular Structure, Biosynthesis, and Pathogenic Roles of Lipopolysaccharides

81

(16)

Anthony P. Moran

Vacuolating Cytotoxin

97

(16)

John C. Atherton

Timothy L. Cover

Emanuele Papini

John L. Telford

III. Energy Metabolism and Synthetic Pathways

Microaerobic Physiology: Aerobic Respiration, Anaerobic Respiration, and Carbon Dioxide Metabolism

113

(12)

David J. Kelly

Nicky J. Hughes

Robert K. Poole

Nitrogen Metabolism

125

(10)

Hilde De Reuse

Stephane Skouloubris

The Critic Acid Cycle and Fatty Acid Biosynthesis

135

(12)

David J. Kelly

Nicky J. Hughes

Nucleotide Metabolism

147

(12)

George L. Mendz

Biosynthetic Pathways Related to Cell Structure and Function

159

(8)

Partha Krishnamurthy

Suhas H. Phadnis

Cindy R. DeLoney

Raoul S. Rosenthal

Bruce E. Dunn

Evasion of the Toxic Effects of Oxygen

167

(12)

Stuart L. Hazell

Andrew G. Harris

Mark A. Trend

IV. Physiology and Molecular Biology

Urease

179

(14)

Harry L. T. Mobley

Ion Metabolism and Transport

193

(14)

Arnoud H. M. van Viliet

Stefan Bereswill

Johannes G. Kusters

Metabolite Transport

207

(12)

Brendan P. Burns

George L. Mendz

Protein Export

219

(8)

Dag Ilver

Rino Rappuoli

John L. Telford

Alternative Mechanisms of Protein Release

227

(12)

Steven R. Blanke

Dan Ye

Motility, Chemotaxis, and Flagella

239

(10)

Gunther Spohn

Vincenzo Scarlato

Natural Transformation, Recombination, and Repair

249

(10)

Wolfgang Fischer

Dirk Hofreuter

Rainer Haas

Chromosomal Replication, Plasmid Replication, and Cell Division

259

(10)

Hiroaki Takeuchi

Teruko Nakazawa

Restriction and Modification Systems

269

(8)

John P. Donahue

Richard M. Peek, Jr.

Regulation of Urease for Acid Habitation

277

(8)

George Sachs

David R. Scott

David L. Weeks

Marina Rektorschek

Klaus Melchers

Transcription and Translation

285

(10)

Sanjib Bhattacharyya

Mae F. Go

Bruce E. Dunn

Suhas H. Phadnis

V. Genetics

The Genome

295

(18)

Richard A. Alm

Brian Noonan

Genetic Exchange

313

(8)

Dawn A. Israel

Gene Regulation

321

(14)

Nicolette de Vries

Arnoud H. M. van Vliet

Johannes G. Kusters

Mutagenesis

335

(10)

Agnes Labigne

Peter J. Jenks

The cag Pathogenicity Island

345

(10)

Markus Stein

Rino Rappuoli

Antonello Covacci

Population Genetics

355

(8)

Sebastian Suerbaum

Mark Achtman

Heterogeneity and Subtyping

363

(18)

Robert J. Owen

Diane E. Taylor

Ge Wang

Leen-Jan van Doorn

VI. Bacterial Virulence and Pathogenic Mechanisms

Adherence and Colonization

381

(38)

Traci L. Testerman

David J. McGee

Harry L. T. Mobley

Lipopolysaccharide Lewis Antigens

419

(10)

Ben J. Appelmelk

Christina M. J. E. Vandenbroucke-Grauls

Gastric Autoimmunity

429

(12)

Mathijs P. Bergman

Gerhard Faller

Mario M. D'Elios

Gianfranco Del Prete

Christina M. J. E. Vandenbroucke-Grauls

Ben J. Appelmelk

Vaccines

441

(18)

Jacques Pappo

Steven Czinn

John Nedrud

VII. Pathogenesis in the Host, Diagnosis, and Treatment

Pathology of Gastritis and Peptic Ulceration

459

(12)

Michael F. Dixon

Host Inflammatory Response to Infection

471

(10)

Jide Wang

Thomas G. Blanchard

Peter B. Ernst

Gastric Cancer

481

(18)

Masahiro Asaka

Antonia R. Sepulveda

Toshiro Sugiyama

David Y. Graham

Markers of Infection

499

(12)

David Y. Graham

Waqar A. Qureshi

Antibiotic Susceptibility and Resistance

511

(22)

Francis Megraud

Stuart Hazell

Youri Glupczynski

VIII. Animal Models and Other Helicobacter Species

Enterohepatic Helicobacter Species

533

(16)

David B. Schauer

Other Gastric Helicobacters and Spiral Organisms

549

(16)

Stephen J. Danon

Adrian Lee

In Vivo Modeling of Helicobacter-Associated Gastrointestinal Diseases

565

(18)

Richard L. Ferrero

James G. Fox

In Vivo Adaptation to the Host

583

(10)

Richard L. Ferrero

Peter J. Jenks

Index

593

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Summary

Table of Contents

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Helicobacter Pylori

Summary

Table of Contents

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