High-Throughput Mass Spectrometry in Drug Discovery

Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide

Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry.

High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development.

High-Throughput Mass Spectrometry in Drug Discovery readers will also find:

• Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more
• An authorial team with extensive combined experience in research and industrial applications
• Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery

High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.

Chang Liu, Ph.D., is a Staff Research Scientist at SCIEX, a global leader in the design and production of mass spectrometers. He has published extensively on using mass spectrometry in drug discovery and development.

Hui Zhang, Ph.D., is the Vice President of Analytical Technologies at Entos, a biotech company focusing on Artificial Intelligence and High Throughput Experimentation driving drug discovery. He has published widely on mass spectrometry and its pharmaceutical applications through his previous tenure at Pfizer.

Preface

List of abbreviations

Section 1 Introduction

Chapter 1 Forty Year Evolution of High Throughput Mass Spectrometry: A Perspective.

Thomas R. Covey

Section 2  LC-MS

Chapter 2 The LeadSampler (LS-1) sample delivery system: integrated design and features for high-            efficiency bioanalysis

Brendon Kapinos, Wayne Lootsma, John Janiszewski

Chapter 3 Evolution of Multiplexing technology for high throughput LC/MS analyses

Adam Latawiec

Section 3  ESI-MS without chromatographic separation

Chapter 4 Direct Online SPE-MS for High-Throughput Analysis in Drug Discovery

Andrew D. Wagner, Wilson Z. Shou

Chapter 5 Acoustic Sampling for Mass Spectrometry: Fundamentals and Applications in High-        Throughput Drug Discovery

Chang Liu, Lucien Ghislain, Jonathan Wingfield, Sammy Datwani, Hui Zhang

Chapter 6 Recent advances in ion mobility-mass spectrometry for drug discovery

Xueyun Zheng

Chapter 7 Differential Mobility Spectrometry and its Application to High Throughput Analysis

Bradley B. Schneider, Leigh Bedford, Chang Liu, Eva Duchoslav, Yang Kang, Subhasish Purkayastha, Aaron Stella, Thomas R. Covey

Section 4 Special Sample Arrangement

Chapter 8 Off-line Affinity Selection Mass Spectrometry and its Application in Lead Discovery

Christopher F. Stratton, Lawrence M. Szewczuk, Juncai Meng

Chapter 9 On-line Affinity Selection Mass Spectrometry

Hui Zhang, Juncai Meng

Chapter 10 Native Mass Spectrometry in Drug Discovery and Development

Mengxuan Jia, Jianzhong Wen, Olivier Mozziconacci, Elizabeth Pierson

Section 5 Other Ambient Ionization other than ESI

Chapter 11 Laser Diode Thermal Desorption-Mass Spectrometry (LDTD-MS): Fundamentals and Applications of sub-second analysis in Drug discovery environment

Pierre Picard, Sylvain Letarte, Jonathan Rochon, Réal E. Paquin

Chapter 12 Accelerating Drug Discovery with Ultrahigh-Throughput MALDI-TOF MS

Sergei Dikler

Chapter 13 Development and applications of DESI-MS in drug discovery

Wenpeng Zhang

Section 6 Conclusion

Chapter 14 The impact of HT-MS to date and it’s potential to shape the future of metrics-based experimentation and analysis

Mathew D. Troutman

Index

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