The Human Frontal Lobes Functions and Disorders

This authoritative work, now thoroughly revised, has given thousands of clinicians, students, and researchers a state-of-the-art understanding of the human frontal lobes--the large brain region that plays a critical role in behavior, cognition, health, and disease. Leading experts from multiple disciplines address the anatomy and chemistry of the frontal cortex, neuropsychological assessments of capabilities unique to the frontal lobes, the nature of (and possible treatment avenues for) frontotemporal dementia and related conditions, and implications for understanding and treating neuropsychiatric disorders, such as schizophrenia, mania, and depression. Illustrations include eight pages in full color.

New to This Edition:
*Reflects a decade of important research advances in such areas as functional connectivity mapping of frontal and frontal-subcortical circuits.
*Incorporates significant new information on frontotemporal dementia and other neurological disorders.
*Expanded section on neuropsychiatric disorders, with new chapters on apathy, dissociative states, and antisocial behavior.
*Chapters on salience networks, normal brain aging, white matter diseases, and clinical trials.
*Increased attention to brain processes involved in moral reasoning, empathy, decision making, and other key human capabilities.

Bruce L. Miller, MD, is the A. W. and Mary Margaret Clausen Distinguished Professor of Neurology at the University of California, San Francisco (UCSF), and Director of the UCSF Memory and Aging Center. Dr. Miller is a behavioral neurologist focused on dementia, with special interests in brain-behavior relationships as well as the genetic and molecular underpinnings of disease. He currently conducts research on frontotemporal dementia, oversees a healthy aging program, and helps lead two privately funded research consortia. He also works with the National Football League to help with the education and assessment of players related to brain health. Dr. Miller is a recipient of the Potamkin Award from the American Academy of Neurology, the Raymond D. Adams Lectureship from the American Neurological Association, the J. Elliot Royer Award from the San Francisco Neurological Society, the UCSF Annual Faculty Research Lectureship in Clinical Science, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging, among many other honors. With more than 600 scientific publications, Dr. Miller has served since 1984 as Scientific Director of the John Douglas French Alzheimer’s Foundation.
 
Jeffrey L. Cummings, MD, ScD, is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada, and Cleveland, Ohio. He is the Camille and Larry Ruvo Chair for Brain Health at the Cleveland Clinic Neurological Institute and Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. A leading authority on Alzheimer's disease, Dr. Cummings is interested in clinical trials, developing new therapies for brain diseases, and the interface of neuroscience and society. He is a recipient of the Henderson Award from the American Geriatrics Society, the Research Award from the John Douglas French Alzheimer’s Foundation, the Ronald and Nancy Reagan Research Award from the Alzheimer’s Association, and the Distinguished Scientist Award from the American Association of Geriatric Psychiatry, among many other honors. Dr. Cummings has more than 700 scientific publications and is a past president of the Behavioral Neurology Society and the American Neuropsychiatric Association. 

I.          Neuroanatomy and Neurochemistry
1. The Human Frontal Lobes: An Introduction, Bruce L. Miller and Jeffrey L. Cummings
2.         The Mesocortical Dopaminergic System, Billy T. Chen and Antonello Bonci
3.         The Dorsolateral and Cingulate Cortex , James R. Bateman and Daniel I. Kaufer
4. The Orbitofrontal Cortex and the Insula, Eun-Joo Kim, Jennifer Ogar, and Maria Luisa Gorno-Tempini
5. Structural and Functional Asymmetries of the Human Frontal Lobes, Daniel H. Geschwind and Marco Iacoboni
6.         Gross Morphology and Architectonics, Helmut Heinsen and Lea Tenenholz Grinberg
II.        Assessment: Neuropsychology and Behavior
7. The Frontal Lobes and Executive Control, Adam Gazzaley, Taraz G. Lee, and Mark D’Esposito
8.         Bedside Frontal Lobe Testing, Adam M. Staffaroni, Melanie L. Stephens, and Joel H. Kramer
9. The Prefrontal Cortex and Human Memory, Nick Diamond and Brian Levine
10. Language and Frontal Cortex, Marlís González-Fernández and Argye E. Hillis
11.       Self-Awareness and Frontal Lobe Networks, Virginia E. Sturm, Alice Y. Hua, and Howard J. Rosen
12.       Decision-Making Capacity and Frontal Lobe Dysfunction, Sarah M. Hooper and Winston Chiong
13. Socioemotional Functioning and Frontal Lobe Injury, Katherine P. Rankin, Kelly Gola, and Tracy L. Jerard
14.       Salience Networks: Magnetic Resonance Imaging Interrogation of Self-Concepts in Dementia, Winston Chiong
III.       Neurological Diseases
Section A: FTD and Related Disorders
15.       Clinical Aspects of Frontotemporal Dementia, David C. Perry and Bruce L. Miller
16.       Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex,                       Anne-Catherine Vijverman, Maria Carmela Tartaglia, and Anthony E. Lang
17.       Neuropathology of Frontotemporal Dementias, Nigel J. Cairns, David J. Irwin, Vivianna M. Van Deerlin, Virginia M.-Y. Lee, and John Q. Trojanowski
18. Frontotemporal Dementia Neurogenetics, Leonel T. Takada
Section B: Other Disorders
19. Normal Aging of the Frontal Lobes,                    Brianne Bettcher
20        . Vascular Cognitive Impairment: Executive Dysfunction in the Era of the Human Brain Connectome,             Helena C. Chui and Liliana Ramirez Gomez
21.       White Matter Diseases of the Frontal Lobes, Christopher M. Filley
22        . Parkinson’s Disease, Parkinson’s Disease with Dementia, and Dementia with Lewy Bodies, Jee Bang, Sharon J. Sha, and Katherine L. Possin
23.       Traumatic Brain Injury, Judith Aharon-Peretz
IV.       Neuropsychiatric Disorders
24.       Prefrontal Cortical Dysfunction in Schizophrenia: Clinical Implications and Novel Treatment Development, Daniel Fulford, Joshua D. Woolley, and Sophia Vinogradov
25. Mania and the Frontal Lobes, Mary G. De May and Bruce L. Miller
26.       Obsessive–Compulsive Disorder,                   Edwin H. Rodriguez and Carol A. Mathews
27        . Depression and the Frontal Lobes, Ira Lesser, Julia Chung, and Weiguo Zhu
28. Apathy, Georges Naasan
29        . Frontal Lobe Seizures, Frontal Cortex, and Dissociative States, Anli Liu and Orrin Devinsky
30        . The Role of the Frontal Lobes in Antisocial and Aggressive Behavior: Review of the Research and Legal Implications, Annette L. Ermshar and Kyle Brauer Boone
V         . Treatment
31.       Neurosurgical Treatments for Psychiatric Disorders, Simon Ducharme, Darin D. Dougherty, and Bruce H. Price
32        . Clinical Trials in Frontotemporal Lobar Degeneration, Gabriel C. Léger, Sarah J. Banks, and Jeffrey L. Cummings
Index