Idiotypes in Medicine: Autoimmunity, Infection and Cancer

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ISBN: 9780444828071 | 0444828079
Cover: Hardcover
Copyright: 11/19/1997

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This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

List of Contributors

vii

General Section

(50)

Anti-idiotypes as Vaccines: Theoretical Considerations

(8)

A. Nisonoff

Anti-idiotypes

(8)

C. A. Bona

X-ray Crystallographic Studies of the Idiotypic Cascade

(18)

N. Ban

A. McPherson

The Structure and Thermodynamics of Antibody-Protein Antigen Interactions

(16)

B. C. Braden

R. J. Poljak

Autoimmunity Section

(204)

Introduction - Idiotypes and Anti-idiotypes

(12)

M. Abu-Shakra

D. Buskila

Y. Shoenfeld

Cross-Reactive Idiotypes in Human Lupus Families

(10)

P. Youinou

Idiotypes of Anti-DNA Antibodies

(14)

D. Buskila

M. Abu-Shakra

Y. Shoenfeld

Idiotypes of Anti-Sm Antibodies

(6)

H. Dang

N. Talal

Idiotypes of Anti-Ro and Anti-La

(4)

Y. B. Dayan

H. Amital

Y. Shoenfeld

Idiotypes on Autoantibodies in Myasthenia Gravis

(8)

A. K. Lefvert

Idiotypes of ANCA

107

(6)

E. Csernok

W. L. Gross

Ig Genes and Idiotype of Anti-Mitochondrial Antibodies in Primary Biliary Cirrhosis

113

(6)

P. S. C. Leung

M. E. Gershwin

Idiotypes of Anti-Phospholipid Antibodies

119

(10)

R. Bakimer

Y. Shoenfeld

Anti-Idiotypic Antibodies Against Human Insulin Autoantibodies (IAA)

129

(6)

S. Kyurkchiev

M. Stamenova

V. Manolova

V. Tsvetkova

L. Dakovska

I. Kehayov

Molecular and Cellular Aspects of Human Rheumatoid Factor Production and Idiotypes

135

(22)

R. A. Mageed

S. P. Moyes

K. M. Thompson

J. B. Natvig

Idiotypes of Anti-Thyroglobulin Antibodies

157

(8)

Y. Tomer

Idiotypes of Human Platelet-Specific Antibodies

165

(24)

T. J. Kunicki

D. J. Nugent

Idiotypes of Platelet Associated Antibodies (Autoimmune Thrombocytopenia)

189

(4)

M. Abu-Shakra

D. Buskila

Y. Shoenfeld

Idiotypes of Natural Autoantibodies and Monoclonal Gammopathies

193

(12)

M. Abu-Shakra

D. Buskila

Y. Shoenfeld

Idiotypes and Anti-Idiotypes in Allergy

205

(12)

M. G. Jacquemin

J. -M. R. Saint-Remy

Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG (Intravenous Immunoglobulin, IVIg)

217

(10)

S. H. Spalter

S. Kaveri

M. D. Kazatchkine

Manipulation of Autoantibody Idiotypes In Autoimmune Diseases

227

(12)

D. Buskila

M. Abu-Shakra

Y. Shoenfeld

Anti-Idiotypic Monoclonal Antibody (mAb) to Anti-CD4 mAb as Surrogate of Human CD4 Antigen (Ag) for Active Immunotherapy of Autoimmune Diseases

239

(18)

F. Perosa

M. Scudeletti

F. Indiveri

F. Dammacco

Infection Section

257

(172)

Introduction

257

(2)

R. C. Kennedy

Anti-Idiotypic Studies of the Glycoprotine B (gB, UL55) Complex of Human Cytomegalovirus: Mimicry of a Neutralizing Epitope and Development of Diagnostics

259

(10)

E. S. Tackaberry

J. Hamel

B. R. Brodeur

Anti-Idiotype Antibody in HIV-1-Infected Thrombocytopenic Patients

269

(12)

S. Karpatkin

M. A. Nardi

An Electron Microscopic View of the Geometry and Dynamics of Idiotype-Anti-Idiotype Interactions

281

(12)

K. H. Roux

N. S. Greenspan

Probing Human Antibody Diversity in HIV Infection

293

(10)

S. Karray

M. Zouali

Anti-Idiotype Mimics of Pseudomonas Aeruginosa Surface Polysaccharides

303

(14)

J. R. Schreiber

Modulation of the Immune Response to Simian Virus 40 Large Tumor Antigen via Idiotype-Anti-Idiotype Interactions

317

(14)

M. H. Shearer

H. I. Pass

M. Carbone

R. C. Kennedy

The Perpetual Network Theory and its Putative Applications: 21 Years Later

331

(10)

H. C. J. Ertl

An Anti-Idiotypic Antibody as a Functional Mirror Image of a Viral Antigen

341

(6)

Y. Thanavala

Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine

347

(10)

E. -M. Zhou

M. Lin

An Idiotype Vaccine Against Gram-Negative Bacterial Sepsis

357

(12)

R. E. Ward

Yeast Killer Toxin-Like Antibodies in Experimental and Clinical Candidasis

369

(12)

L. Polonelli

F. De Bernardis

S. Conti

M. Gerloni

A. Cassone

Anti-Idiotype Antibodies and Idiotypic T Cell Selection in HIV Infection: 1. Idiotypes on HIV Specific Antibodies as Disease Markers in AIDS and their Potential as Immunotherapeutic Agents 2. T Cell Repertoire and Idiotypes in HIV Infection

381

(14)

S. Muller

M. Grant

Probing Human Polysaccharide-Specific Antibody Repertoires using Anti-Idiotypes

395

(12)

A. H. Lucas

Anti-Idiotypic Antibodies in HIV-Infected Patients to a Neutralizing Mab and its Complementarity Determining Regions

407

(8)

M. Levi

J. Hinkula

B. Wahren

Epstein-Barr Virus-Induced Autoimmunity Through Anti-Idiotype Studies

415

(14)

C. Garzelli

M. Incaprera

A. Bazzichi

G. Falcone

Cancer Section

429

(108)

Introduction

429

(2)

S. Ferrone

Cancer Therapy with Anti-Idiotypic Antibodies

431

(10)

O. Merimsky

P. Fishman

Y. Shoenfeld

Immunotherapy of Cancer Patients with Anti-Idiotype Vaccines

441

(14)

M. Bhattacharya-Chatterjee

H. Kohler

K. A. Foon

Anti-Idiotype Antibodies Mimicking Carcinoembryonic Antigen

455

(6)

M. Monestier

Immunological and Molecular Characterization of an Idiotypic Cascade Specific for the Human Carcinoembryonic Antigen

461

(16)

M. Neumaier

F. -J. Gaida

D. Pieper

M. A. Sherman

J. E. Shively

Anti-Idiotypic Antibodies that Mimic the Colorectal Cancer Antigen CO17-1A GA733: Twelve Years of Pre-Clinical and Clinical Studies

477

(14)

D. Herlyn

R. Somasundaram

L. Jacob

W. Li

J. Zaloudik

H. Maruyama

A. Benden

D. Harris

M. Mastrangelo

Idiotypic Network Responses and Anti-Idiotypes in Cancer Therapy

491

(8)

J. Fagerberg

P. Ragnhammar

H. Mellstedt

Anti-Idiotypes in Ovarian Cancer

499

(12)

U. Wagner

H. Schlebusch

J. Schmolling

J. Reinsberg

D. Krebs

Anti-Idiotype Antibodies in Renal Cell Carcinoma

511

(6)

H. Uemura

E. Oosterwijk

Clinical Studies with Anti-Idiotypic Monoclonal Antibody BEC2 that Mimics GD3 Ganglioside

517

(6)

P. B. Chapman

The Anti-Idiotypic Approach to Active Specific Immunotherapy of Malignant Melanoma

523

(14)

X. Wang

S. Desai

E. J. Noronha

A. Mittelman

S. Ferrone

Subject Index

537

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Idiotypes in Medicine: Autoimmunity, Infection and Cancer

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