Illuminating Life: Selected Papers from Cold

This volume showcases reprints of 20 significant papers published by scientists while at Cold Spring Harbor Laboratory, with a non-technical explanation of the work's significance at the time and a profile of the investigator concerned.

Jan Witkowski, Ph.D. trained in biochemistry at the University of London. Since 1987, he has been the Director of the Banbury Center, Cold Spring Harbor, New York.

Foreword

vii

Preface

ix

Acknowledgments

xiii

Prologue: How the Laboratory Was Planted at Cold Spring Harbor and Why It Grew There

xv

Ecology, Adaptation, and Evolution---Early Research at Cold Spring Harbor

1

(22)

The Animal Ecology of the Cold Spring Sand Spit, with Remarks on the Theory of Adaptation

Davenport C.B.

The Early Applications of Mendel's Genetics to Human Beings

23

(6)

Heredity of Eye-Color in Man

Davenport G.C.

Davenport C.B.

The Development of Hybrid Corn at Cold Spring Harbor

29

(18)

The Composition of a Field of Maize

Shull G.H.

A Pure-line Method in Corn Breeding

Shull G.H.

Chromosomal Changes and Heredity

47

(6)

Chromosomal Duplication and Mendelian Phenomena in Datura Mutants

Blakeslee A.F.

Belling J.

Farnham M.E.

Mouse Headquarters, Cold Spring Harbor

53

(24)

The Heredity of Susceptibility to a Transplantable Sarcoma (J.W.B.) of the Japanese Waltzing Mouse

Little C.C.

Studies on Leukemia in Mice: I: The Experimental Transmission of Leukemia

Richter M.N.

MacDowell E.C.

Unstable Genes in Drosophila

77

(10)

Reddish---A Frequently ``Mutating'' Character in Drosophila virilis

Demerec M.

Quantitative Biology Comes to the Biological Laboratory---Isolating Hormones

87

(8)

The Treatment of Patients with Addison's Disease with the ``Cortical Hormone'' of Swingle and Pfiffner

Rowntree L.G.

Greene C.H.

Swingle W.W.

Pfiffner J.J.

The Genetics of Taste and Smell

95

(14)

Genetics of Sensory Thresholds: Taste for Phenylthiocarbamide

Blakeslee A.F.

Pigeons, Hormones, and Lactation

109

(8)

A New Hormone of the Anterior Pituitary

Riddle O.

Bates R.W.

Dykshorn S.W.

Quantitative Biology: Biophysics in the Biological Laboratory

117

(8)

Electric Impedance of Suspensions of Yeast Cells

Fricke H.

Curtis H.J.

Broken Chromosomes

125

(10)

The Fusion of Broken Ends of Chromosomes following Nuclear Fusion

McClintock B.

Penicillin: The Department of Genetics at War

135

(10)

Production of Penicillin. United States Patent

Demerec M.

Development of a High-yielding Strain of Penicillium

Demerec M.

The Unstable Genome---Movable Genes

145

(40)

Chromosome Organization and Genic Expression

McClintock B.

Dissecting the Bacteriophage Life Cycle

185

(16)

The Intracellular Growth of Bacteriophages. I. Liberation of Intracellular T4 by Premature Lysis with Another Phage or with Cyanide

Doermann A.

The Hershey--Chase Experiment

201

(22)

Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage

Hershey A.

Chase M.

Assembly Line Genes

223

(34)

Tryptophan Mutants in Salmonella typhimurium

Demerec M.

Hartman Z.

First Glimpses of DNA Repair

257

(22)

Time, Temperature, and Protein Synthesis: A Study of Ultraviolet-induced Mutation in Bacteria

Witkin E.M.

DNA and the T2 Phage Chromosome

279

(12)

An Estimate of the Length of the DNA Molecule of T2 Bacteriophage by Autoradiography

Cairns J.

The Sticky Ends of Phage λ and Their Uses

291

(12)

Cohesion of DNA Molecules Isolated from Phage Lambda

Hershey A.D.

Burgi E.

Ingraham L.

DNA Synthesis and the Case of the Missing Enzyme

303

(70)

Isolation of an E. coli Strain with a Mutation Affecting DNA Polymerase

De Lucia P.

Cairns J.

Appendices: Directors at Cold Spring Harbor

Charles B. Davenport

311

(50)

Charles Benedict Davenport 1866--1944. A Study of Conflicting Influences

MacDowell E.C.

Reginald G. Harris

361

(6)

Anonymous. 1982. Reginald Harris and the Biological Laboratory

Milislav Demerec

367

(6)

Milislav Demerec 1895--1966

Wallace B.

Name Index

373

(6)

Subject Index

379

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Illuminating Life: Selected Papers from Cold Spring Harbor, Volume 1 (1903-1969)

Summary

Author Biography

Table of Contents

Supplemental Materials