Immunopotentiators in Modern Vaccines

This book provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations.

Preface

vii

List of contributors

ix

Part I: Perspective on immunological mechanisms underlying adjuvant activity

Unraveling ``the immunologist's dirty little secret''

1

(16)

Virgil E.J.C. Schijns

Part II: Host-derived immunopotentiators

Dendritic cells as targets and tools in vaccines

17

(18)

Imerio Capone

Paola Rizza

Filippo Belardelli

Host-derived molecules as adjuvants

35

(22)

Tom Barr

Jennifer Carlring

Andrew W. Heath

Part III: Natural and synthetic immunopotentiators

Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants

57

(16)

Achal Pashine

Jeffrey B. Ulmer

Nicholas M. Valiante

CpG oligodeoxynucleotides as vaccine adjuvants

73

(20)

Michael J. McCluskie

Risini D. Weeratna

Toll-like receptor 4 agonists as vaccine adjuvants

93

(16)

David H. Persing

Patrick McGowan

Jay T. Evans

Christopher Cluff

Sally Mossman

David Johnson

Jory R. Baldridge

Immunomodulatory adjuvants from Quillaja saponaria

109

(14)

Charlotte Read Kensil

Part IV: Particulate immunopotentiators and delivery systems

Microparticles as vaccine delivery systems

123

(26)

Derek T. O'Hagan

MF59: a safe and potent adjuvant for human use

149

(12)

Audino Podda

Giuseppe Del Giudice

Derek T. O'Hagan

Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminum salt

161

(18)

Nathalie Garcon

Marcelle Van Mechelen

Martine Wettendorff

Virosomes for vaccine delivery

179

(12)

Ian C. Metcalfe

Reinhard Gluck

The ISCOMATRIX™ adjuvant

191

(26)

Debbie Drane

Martin J. Pearse

Mineral adjuvants

217

(18)

Erik B. Lindblad

Part V: Mucosal/nonparenteral adjuvants

Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin

235

(18)

Jan Holmgren

Cecil Czerkinsky

Ali M. Harandi

Michael Lebens

Jia-Bin Sun

Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant

253

(22)

Richard T. Kenney

Gregory M. Glenn

Part VI: Th-1/CTL adjuvants

T cell adjuvants and novel strategies for their identification

275

(14)

Laurence Van Overvelt

Philippe Moingeon

Part VII: Adjuvants in noninfectious disease vaccines

Vaccination to treat noninfectious diseases: surveying the opportunities

289

(30)

Stephen W. Martin

Martin F. Bachmann

Part VIII: Clinical practice

Clinical evaluation of adjuvants

319

(24)

Jakub K. Simon

Robert Edelman

Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines

343

Elizabeth M. Sutkowski

Marion F. Gruber

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Immunopotentiators in Modern Vaccines

Summary

Table of Contents

Supplemental Materials