Immunoreceptor Signaling

The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions. Written and edited by experts in the field, this volume is essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.

Preface	p. vii
Structural Biology of the T-Cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling	p. 1
ITAM-mediated Signaling by the T-Cell Antigen Receptor	p. 15
It's All about Change: The Antigen-driven Initiation of B-Cell Receptor Signaling	p. 27
The Cytoskeleton Coordinates the Early Events of B-Cell Activation	p. 39
Src-Family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk	p. 55
ZAP-70: An Essential Kinase in T-Cell Signaling	p. 71
The LAT Story: A Tale of Cooperativity, Coordination, and Choreography	p. 89
Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76	p. 111
T-Cell Signaling Regulated by the Tec Family Kinase, Itk	p. 127
An Enigmatic Tail of CD28 Signaling	p. 149
SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors	p. 169
The Coordination of T-Cell Function by Serine/Threonine Kinases	p. 185
Lipid Signaling in T-Cell Development and Function	p. 195
Antigen Receptor Signaling to NF-kB via CARMA1, BCL10, and MALT1	p. 217
Mediation of T-Cell Activation by Actin Meshworks	p. 233
Understanding the Structure and Function of the Immunological Synapse	p. 247
Perspectives for Computer Modeling in the Study of T-Cell Activation	p. 261
Index	p. 277
Table of Contents provided by Ingram. All Rights Reserved.

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Immunoreceptor Signaling

Summary

Table of Contents

Supplemental Materials