The Inside Story: DNA to RNA to Protein

A collection of reprinted articles from the review journal Trends in Biochemical Sciences (TiBS)focusing on the central dogma of molecular biology#x14;DNA makes RNA makes protein. The biographical and autobiographical articles graphically describe the great discoveries in the field from an insider's perspective.

Foreword

ix

Tim Hunt

Preface

xi

Jan A. Witkowski

Overview

The General Idea

xiii

Tim Hunt

Biochemical Era

Albrecht Kossel

1

(2)

S. Rapoport

Albrecht Kossel and the Discovery of Histones

3

(6)

Detlef Doenecke

Peter Karlson

Early Nucleic Acid Chemistry

9

(8)

Fritz Schlenk

P.A. Levene and 2-Deoxy-D-ribose

17

(4)

Joseph S. Fruton

Origins of Molecular Biology

Schrodinger's What is Life?: A 50-Year Reflection

21

(10)

G. Rickey Welch

Schrodinger's What is Life?: Entropy, Order and Hereditary Code-scripts

31

(8)

J.A. Witkowski

Finally, the Beginnings of Molecular Biology

39

(6)

Seymour S. Cohen

Biochemical Origins of Molecular Biology: A Discussion

45

(6)

Robert Olby

The Double Helix

The Biological Role of Nucleic Acids

51

(6)

Peter Karlson

Did a Tragic Accident Delay the Discovery of the Double Helical Structure of DNA?

57

(10)

Keith L. Manchester

The Double Helix and All That

67

(10)

H.R. Wilson

Light on a Dark Lady

77

(12)

Anne Piper

Replication

The DNA Replication Problem, 1953-1958

89

(12)

Frederic L. Holmes

Tritium-labeled Thymidine and Early Insights into DNA Replication and Chromosome Structure

101

(8)

J. Herbert Taylor

DNA Replication: The 30th Anniversary of the Bacterial Model and the ``Baby Machine''

109

(10)

Stephen Cooper

DNA Molecules

DNA Strand Separation, Renaturation and Hybridization

119

(10)

Julius Marmur

Blotting at 25

129

(10)

Ed M. Southern

One Chromosome: One DNA Molecule

139

(8)

Bruno H. Zimm

Through the Looking Glass: The Discovery of Supercoiled DNA

147

(14)

Jacob Lebowitz

DNA, RNA, and Protein Synthesis

Protein Synthesis

Ernest F. Gale and Protein Synthesis: The Difficulties of Analysing a Complex System

161

(10)

Hans-Jorg Rheinberger

Reminiscences about Nucleic Acid Cytochemistry and Biochemistry

171

(8)

Jean Brachet

Jean Brachet's Alternative Scheme for Protein Synthesis

179

(10)

Denis Thieffry

Richard M. Burian

Genetic Code

Deciphering the Genetic Code---A Personal Account

189

(20)

Marshall Nirenberg

The History of Deciphering the Genetic Code: Setting the Record Straight

209

(4)

Akira Kaji

Hideko Kaji

tRNA

Biochemistry or Molecular Biology? The Discovery of ``Soluble RNA''

213

(8)

Mahlon Hoagland

Back to Camelot: Defining the Specific Role of tRNA in Protein Synthesis

221

(10)

Bernard Weisblum

The Crystallization and Structural Determination of tRNA

231

(12)

Brian F.C. Clark

mRNA

What Was the Message?

243

(10)

Elliot Volkin

An RNA Heresy in the Fifties

253

(8)

Henry Harris

The Discovery of ``Giant'' RNA and RNA Processing: 40 Years of Enigma

261

(14)

Klaus Scherrer

The Discovery of ``Split'' Genes: A Scientific Revolution

275

(12)

J.A. Witkowski

Molecular Basis of Protein Synthesis

The In Vitro Biosynthesis of an Authentic Protein

287

(8)

Norton D. Zinder

Early Days of Ribosome Research

295

(10)

Masayasu Nomura

The Discovery of Polyribosomes

305

(12)

Jonathan R. Warner

Paul M. Knopf

Peptidyl Transfer, the Monro Era

317

(14)

B. Edward H. Maden

Central Dogma

Forty Years under the Central Dogma

331

(14)

Denis Thieffry

Sahotra Sarkar

Sequencing

Protein Sequencing and the Making of Molecular Genetics

345

(10)

Soraya de Chadarevian

pBR322 and the Advent of Rapid DNA Sequencing

355

(12)

J. Gregor Sutcliffe

Biochemistry and Molecular Biology

Biochemistry Strikes Back

367

(4)

Sydney Brenner

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The Inside Story: DNA to RNA to Protein

Summary

Table of Contents

Supplemental Materials