The Interval-Force Relationship of the Heart:

Originally published in 1992, this volume looks in detail at the important relationship, initially studied in 1871 by Bowditch, between the strength of the heartbeat and the interval between beats. The book draws together the work and experience of leading international research workers in this field. Collectively, the contributors illuminated the underlying mechanisms involved, their expression in both isolated muscle and the intact heart, and speculate on further avenues of research. The volume will be of interest to cardiologists, physiologists and all those concerned with the function of the heart.

Contributors
Introduction

On the peculiarities of excitability which the fibres of the cardiac muscle show translated
The General Process:
The interval-strength relationship of cardiac muscle: past, present, and future
A model for interval-force phenomena: unresolved issues
Cellular Processes Underlying Interval-Force Behaviour and their Control:
Relationships between intracellular free calcium and force with changes of interval
The role of intracellular calcium, sodium, and pH in rate-dependent changes of cardiac contractile force
Quantitative aspects of cellular calcium regulation during post-rest stimulation in cardiac muscle: implications for steady-state conditions
Calcium compartmentation and contractive function of the heart
The expression of interval-force phenomena in cardiac muscle:
Myocardial excitation and contraction: factors influencing peak force
Mechanical restitution in cardiac muscle
Post-rest potentiation and its decay
Post-extrasystolic potentiation and its decay
The cellular basis of pulsus alternans
Applicability of myocardial interval-force relationships to the whole ventricle: studies in isolated perfused hearts
Interval-force effects in the pulse variation of atrial fibrillation: a statistical approach
Interval-force processes in the intact animal and human heart
Author index
Subject index
Table of Contents provided by Publisher. All Rights Reserved.

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The Interval-Force Relationship of the Heart: Bowditch Revisited

Summary

Table of Contents

Supplemental Materials