An Introduction to Pharmacovigilance

Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems.

Patrick Waller MD, MPH, FRCPEd, FFPM, Formerly Honorary Professor, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Mira Harrison-Woolrych BM, DM, DFFP, FRCOG, Honorary Research Associate Professor, Dunedin School of Medicine, University of Otago, New Zealand; Senior Medical Assessor, Vigilance and Risk Management, Medicines and Healthcare products Regulatory Agency (MHRA), London, UK and Secretary General of the International Society of Pharmacovigilance (ISoP).

Foreword ix

Preface to the Second Edition xi

Preface to the First Edition xiii

Acknowledgements xv

List of Abbreviations xvii

1 What is Pharmacovigilance and How Has it Developed? 1

2 Basic Concepts 19

3 Types and Sources of Data 37

4 The Process of Pharmacovigilance 55

5 Regulatory Aspects of Pharmacovigilance 75

6 International Collaboration 95

7 Clinical Aspects of Adverse Drug Reactions 109

8 Ethical and Societal Considerations 123

9 Future Directions 135

10 Learning More About Pharmacovigilance 145

Glossary 151

Index 157

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