Itch: Basic Mechanisms and Therapy

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ISBN: 9780824747473 | 082474747X
Cover: Hardcover
Copyright: 1/6/2004

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This blue-ribbon reference compiles the latest research and recommendations from leading specialists in the field to offer a concise and multidisciplinary discussion of the basic aspects of itch, diseases in which itch serves as a major component, and recent procedures for the assessment and control of itch in patient care.

Foreword Thomas A. Luger

vii

Preface

Contributors

Part I. Clinical Classification of Itch

1. Definitions of Itch

(4)

Gil Yosipovitch and Malcolm W. Greaves

Part II. Basic Mechanisms of Itch

2. Neurophysiologic Basis of Itch

(8)

Martin Schmelz and Hermann O. Handwerker

3. Pain and Itch

(8)

Martin Schmelz and Hermann O. Handwerker

4. Central Neural Mechanisms of Itch

(14)

David Andrew and A.D. Craig

5. Animal Models of Itch: scratching Away at the Problem

(16)

Earl Carstens and Yasushi Kuraishi

6. Histamine-Induced Discriminative and Affective Responses Revealed by Functional MRI

(12)

Francis McGlone, Roman Rukwied, Matt Howard, and David Hitchcock

7. Central Nervous system Imaging of Itch with PET

(8)

Ulf Darsow, Alexander Drzezga, and Johannes Ring

8. Skin Nerve Anatomy: Neuropeptide Distribution and Its Relationship to Itch

(16)

Dieter Metze

9. Substance P and Itch

(10)

Tsugunobu Andoh and Yasushi Kuraishi

10. Peripheral Opiate Receptor System in Human Epidermis and Itch

(10)

Paul Lorenz Bigliardi and Mei Bigliardi-Qi

11. Antipruritic Activity of a Novel κ-Opioid Receptor Agonist, TRK-820

107

(8)

Jun Utsumi, Yuko Togashi, Hideo Umeuchi, Kiyoshi Okano, Toshiaki Tanaka, and Hiroshi Nagase

12. Putative Role of Cannabinoids in Experimentally Induced Itch and Inflammation in Human Skin

115

(16)

Roman Rukwied, Melity Dvorak, Allan Watkinson, and Francis McGlone

13. Itch Models in Animals, with Special Emphasis on the Serotonin Model in Rats

131

(8)

Jens Schiersing Thomsen

14. Human Itch Models, with Special Emphasis on Itch in SLS-Inflamed and Normal Skin

139

(8)

Jens Schiersing Thomsen

Part III. Evaluation of Patients with Itch

15. Microdialysis in Itch Research

147

(14)

Martin Schmelz

16. Measuring Nocturnal Scratching in Atopic Dermatitits

161

(8)

Toshiya Ebata

17. Itch Questionnaires as Tools for Itch Evaluation

169

(14)

Gil Yosipovitch

Part IV. Epidemiology and Characteristics of Itch

18. Epidemiology of Itching in Skin and Systemic Diseases

183

(10)

Gil Yosipovitch

19. Uremie Pruritus: New Perspectives and Insights from Recent Trials

193

(12)

Thomas Mettang, Dominik Mark Alscher, and Christiane Pauli-Magnus

20. Pruritus Complicating Liver Disease

205

(14)

Nora V. Bergasa and E. Anthony Jones

21. Itch in HIV-Infected Patients

219

(12)

Maria I.. Duque, Gil Yosipovitch, and P. Samuel Pegram

22. Neuropathic Pruritus

231

(10)

Gil Yosipovitch, Rashel Goodkin, Ellen Mary Wingard, and Jeffrey D. Bernhard

23. Clinical Features of Itch in Atopic Eczema

241

(6)

Ulf Darsow and Johannes Ring

24. Postburn Itch

247

(8)

Robert D. Nelson

25. Pruritus in Lichen Simplex Chronicus and Lichen Amyloidosis

255

(4)

Yung-Hian Leow and Gil Yosipovitch

Part V. Treatment of Itch

26. Treatment of Pruritus in Internal and Dermatological Diseases with Opioid Receptor Antagonists

259

(20)

Sonja Ständer and Dieter Metze

27. Prospects for a Novel κ-Opioid Receptor Agonist, TRK-820, in Uremic Pruritus

279

(8)

Hiroo Kuniagai, Shigeaki Matsukawa, Jun Utsumi, and Takao Saruta

28. Treatment of Pruritic Skin Diseases with Topical Capsaicin

287

(18)

Sonja Ständer and Dieter Metze

29. Mechanistic and Clinical Assessment of Zangrado®, an Extract of the Amazonian Ethnomedicine Sangre de Grado, for the Treatment of Itch

305

(10)

Mark J.S. Miller, Brian K. Reuter, John L. Wallace, Keith A. Sharkey, and Paul Bobrowski

30. Reduction in itch severity with Topical Immunomodulators: A New Approach for Patients with Inflammatory Disease

315

(10)

Alan B. Fleischer, Jr.

31. 5-HT3 Receptor Antagonists as Antipruritics

325

(10)

Elke Weisshaar

32. Cutaneous Nerve Stimulation in Treatment of Localized Itch

335

(8)

Joanna Wallengren

Part VI. Social and Psychological Aspects

33. Psychosomatic Aspects of Pruritus

343

(8)

Uwe Gieler, Volker Niemeier, Burkhard Brosig, and Jörg Kupfer

34. On Psychological Factors Affecting Reports of Itch Perception

351

(18)

Elia E. Psouni

35. Itching as a Focus of Mental Disturbance

369

(8)

Yuval Melamed and Gil Yosipovitch

Index

377

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Itch: Basic Mechanisms and Therapy

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Table of Contents

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Itch: Basic Mechanisms and Therapy

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