Liposome Technology: Interactions of Liposomes with the Biological Milieu

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780849397257 | 0849397251
Cover: Hardcover
Copyright: 9/12/2006

Rent

(Recommended)

$162.23

Term

Due

Price

Semester

Dec 17

$162.23

Quarter

Dec 9

$154.12

Short Term

Nov 9

$146.00

*This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping bag.
Buy New

Usually Ships in 3-5 Business Days

$207.69
eBook

Available Instantly

Online: 180 Days

Downloadable: 180 Days

*To support the delivery of the digital material to you, a digital delivery fee of $3.99 will be charged on each digital item.

$56.10*

Liposome Technology, Volume III: Interactions of Liposomes with the Biological Milieu, Third Edition, is a comprehensively updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume III describes technologies for yielding liposomes that can function in a targeted fashion, and highlights methods for studying the interaction of liposomes within the biological environment to be applied in the detection, therapy, or prevention of disease. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

Preface

Acknowledgments

Contributors

xix

1. Interactions of Liposomes with Complement Leading to Adverse Reactions

Janos Szebeni, Carl R. Alving, Lajos Baranyi, and Rolf Bünger

Introduction

(2)

Clinical Symptoms and Occurrence of Complement Activation-Related Pseudoallergy

(1)

Mechanisms of Complement Activation by Liposomes

(3)

General Approaches of Measuring the Interaction of Liposomes with the Complement System

(6)

Complement Activation by Doxil and Other Liposomal Drugs

(6)

Conclusions

(1)

References

(6)

2. Fixed Drug Ratio Liposome Formulations of Combination Cancer Therapeutics

(24)

Troy O. Harasym, Paul G. Tardi, Sharon A. Johnstone, Lawrence D. Mayer, Marcel B. Bally, and Andrew S. Janoff

Introduction

(2)

Determination of Drug–Drug Interaction Effects: Synergy vs. Antagonism

(1)

Methodological Approaches to Determining Synergy/Antagonism

(3)

In Vitro Informatics: The Foundation of Fixed-Ratio Formulations

(4)

Finding, Fixing, and Delivering Synergistic Drug Combinations

(2)

Designing Liposomal Systems to Maintain Fixed Drug Ratios In Vivo

(3)

Examples of the Benefits Provided y CombiPlex™ Technology

(5)

Establishing a New Paradigm for Developing Drug Combinations

(1)

References

(3)

3. Pharmacokinetics and Biopharmaceutics of Lipid-Based Drug Formulations

(16)

Theresa M. Allen

Introduction

(1)

Background

(1)

PK of Sustained Release Lipid-Based Formulations vs. Free Drugs Administered Intravenously

(3)

Multicompartment Model for Free Drugs

(2)

Sustained-Release Formulations: Alternate Routes of Administration

(1)

Rapid-Release Formulations of Lipid-Based Drugs

(1)

Effect of Formulation and Drug Release on PK Profiles

(1)

Effect of Drug-Release Rate on Therapeutic Effect

(2)

Bioavailability of Liposomal Drugs

(1)

Effect of Liposome Size, Dosing Schedule, and Dose Intensity

(1)

Maximum Tolerated Dose

(1)

Conclusions

(1)

Glossary

(1)

References

(3)

4. Optimization Strategies in Lymph Node Targeting of Interstitially Injected Immunoglobulin G–Bearing Liposomes

(14)

Seyed M. Moghimi

Introduction

(2)

Rationale

(1)

Methodology

(1)

Lymphatic Distribution of IgG-PEG2000-Liposomes

(5)

Conclusions

(3)

References

(3)

5. Observations on the Disappearance of the Stealth Property of PEGylated Liposomes: Effects of Lipid Dose and Dosing Frequency

(16)

Myrra G. Carstens, Birgit Romberg, Christien Oussoren, Gert Storm, Peter Laverman, and Otto C. Boerman

Introduction

(1)

Effect of Lipid Dose

(2)

Effect of Repeated Administration

(9)

Clinical Implications

(1)

References

(3)

6. Adenosine Triphosphate–Loaded Liposomes for Myocardium Preservation Under Ischemic Conditions

(18)

Daya D. Verma, Tatayana S. Levchenko, William C. Hartner, Eugene A. Bernstein, and Vladimir P. Torchilin

Introduction

(2)

Encapsulation of ATP in Long-Circulating Liposomes

(2)

Effective Protection of Ischemic Heart by ATP-L in an Isolated Rat Heart Model

(4)

Enhanced Cardioprotection by ATP-IL in Isolated Rat Heart Model

103

(5)

Significant Reduction in the Size of the Irreversibly Damaged Fraction of the "Area at Risk" by ATP-L in Rabbits with Experimental MI

108

(1)

Conclusions

109

(1)

References

110

(3)

7. Targeting Tumor Angiogenesis Using Liposomes

113

(14)

Raymond M. Schiffelers, Evisa Gjini, Marcel H.A.M. Fens, and Gert Storm

Introduction

113

(1)

Angiogenesis

114

(1)

Targeting Tumor Angiogenesis

115

(1)

Antibody-Based Targeting of Liposomes

115

(2)

Peptide-Based Targeting of Liposomes

117

(3)

Charge-Based Targeting of Liposomes

120

(2)

Conclusions

122

(1)

References

122

(5)

8. Targeting Liposomes to Endothelial Cells in Inflammatory Diseases

127

(24)

Jan A.A.M. Kamps and Grietje Molema

Introduction

127

(6)

Liposomes Targeted to Endothelial Cells

133

(3)

Methodology

136

(9)

Perspectives of Endothelial Cell–Targeted Liposomes

145

(1)

References

146

(5)

9. Targeting of Cationic Liposomes to Endothelial Tissue

151

(20)

Uwe Michaelis and Heinrich Haas

Introduction

151

(1)

Vascular-Disrupting Agents for Tumor Therapy

152

(2)

Membrane Characteristics of Dividing Endothelial Cells

154

(2)

Cationic Liposomes for Targeted Delivery

156

(1)

Molecular Setup of EndoTAG®

157

(4)

EndoTAG®-1

161

(3)

EndoTAG®-2

164

(2)

Conclusions

166

(1)

References

166

(5)

10. Folate Receptor-Targeted Liposomes

171

(20)

Xiaogang Pan, Robert J. Lee, and Srikanth Shivakumar

Introduction

171

(1)

Folate Receptor as a Tumor Marker

171

(2)

Folate as a Tumor-Targeting Ligand

173

(1)

FR-Targeted Liposomes

174

(9)

Summary

183

(1)

Future Directions

183

(1)

References

184

(7)

11. Methods for Tracking Radiolabeled Liposomes After Injection in the Body

191

(20)

Beth A. Goins and William T. Phillips

Introduction

191

(1)

Advantages of Scintigraphic Imaging Compared with Other Imaging Modalities

192

(1)

Overview of Scintigraphic Imaging Instrumentation and Examples

193

(7)

Scintigraphic Imaging Methodology

200

(5)

Tissue Biodistribution Methodology

205

(1)

Conclusions

206

(1)

References

206

(5)

12. Cytoplasmic Tracking of Liposomes Containing Protein Antigens

211

(20)

Mangala Rao, Kristina K. Peachman, and Carl R. Alving

Introduction

211

(1)

Coupling of Fluorescent Dyes to Protein Antigens

212

(1)

Preparation of Liposomes

213

(2)

Preparation of Antigen-Presenting Cells

215

(3)

Intracellular Visualization of Liposomal Antigen

218

(9)

In Vivo Processing of Liposomal Antigens

227

(1)

Conclusions

227

(1)

References

228

(3)

13. Targeting of Liposomes to Lymph Nodes

231

(22)

William T. Phillips, Beth A. Goins, and Luis A. Medina

Introduction

231

(2)

Important Lymph-Node Targets

233

(2)

Lymph-Node Antigen Delivery for Development of an Immune Response

235

(1)

Use of Imaging to Track Subcutaneously Injected Liposomes

236

(1)

Quantitation of Lymph-Node Delivery

237

(2)

Factors Influencing Liposome Delivery to Lymph Nodes

239

(3)

Liposomes for Lymph-Node Infection Therapy

242

(1)

Liposomes for Lymph-Node Cancer Targeting

243

(6)

Conclusions

249

(1)

References

249

(4)

14. Intracellular Delivery of Therapeutic Oligonucleotides in pH-Sensitive and Cationic Liposomes

253

(24)

Nejat Düzgünes, Sérgio Simões, Montserrat Lopez-Mesas, and Maria C. Pedroso de Lima

Introduction

253

(3)

Cellular Entry of Oligonucleotides

256

(1)

pH-Sensitive Liposomes

257

(3)

Delivery of Therapeutic Oligonucleotides in pH-Sensitive Liposomes

260

(2)

Delivery of Oligonucleotides in Sterically Stabilized pH-Sensitive Liposomes with Prolonged Circulation

262

(1)

Oligonucleotide Delivery by Cationic Liposomes

263

(3)

Targeting of Antisense Oligonucleotides

266

(1)

Concluding Remarks

267

(1)

References

268

(9)

15. Liposomes for Intracavitary and Intratumoral Drug Delivery

277

(26)

William T. Phillips, Beth A. Goins, Ande Bao, and Luis A. Medina

Introduction

277

(1)

Intracavitary Administration of Liposome Encapsulated Therapeutic Agents

278

(13)

Potential of Liposomes for Intratumoral Therapy

291

(6)

Conclusion

297

(1)

References

297

(6)

16. The Liposome-Mediated "Macrophage Suicide" Technique: A Tool to Study and Manipulate Macrophage Activities

303

(14)

Nico van Rooijen and Esther van Kesteren-Hendrikx

Introduction

303

(2)

Comparative Accessibility of Macrophages in Different Tissues

305

(3)

Specificity with Respect to Macrophages

308

(1)

Technical Details

309

(4)

References

313

(4)

17. Lung Surfactants: Correlation Between Biophysical Characteristics, Composition, and Therapeutic Efficacy

317

(30)

Oleg Rosenberg, Andrey Seiliev, and Andrey Zhuikov

Introduction

317

(1)

Basic Biophysical and Biochemical Properties of the Lung Surfactant System

318

(3)

Abnormalities of Lung Surfactant in Different Pathologies

321

(3)

Exogenous Lung Surfactants and Methods of Obtaining Them

324

(5)

Therapeutical Efficacy of Different Lung Surfactants

329

(7)

Conclusion

336

(1)

References

337

(10)

18. Liposomes in Cancer Immunotherapy

347

(14)

Michel Adamina, Reto Schumacher, and Giulio C. Spagnoli

Introduction

347

(1)

Cancer Immunotherapy

348

(1)

Materials and Methods

349

(1)

Results

350

(3)

Discussion

353

(4)

Conclusion

357

(1)

References

357

(4)

19. Preparation of Oil-in-Water Emulsions Stabilized by Liposomes for Vaccine Delivery: Expected Immune Responses

361

(26)

Gary R. Matyas and Carl R. Alving

Introduction

361

(1)

Manufacture of Liposomes

362

(13)

Liposomal Oil-in-Water Emulsions

375

(7)

References

382

(5)

20. A Biotechnological Approach to Formulate Vaccines Within Liposomes: Immunization Studies

387

(18)

Maria Helena Bueno da Costa

Introduction

387

(1)

Materials and Methods

388

(6)

Results and Discussion

394

(8)

References

402

(3)

21. Liposomal Therapeutics: From Animal to Man

405

(12)

Jill P. Adler-Moore, Gerard M. Jensen, and Richard T. Proffitt

Introduction and Scope

405

(1)

Reasonably Well-Established Aspects

406

(1)

Therapeutic Index Enhancement

406

(6)

References

412

(5)

Index

417

Please wait while the item is added to your bag...

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Liposome Technology: Interactions of Liposomes with the Biological Milieu

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Liposome Technology: Interactions of Liposomes with the Biological Milieu

Summary

Table of Contents

Supplemental Materials

Digital License