Liquid Chromatography Time-of-Flight Mass

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants-such as antibiotics, steroids, analgesics-using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

Imma Ferrer, PHD, has twelve years of hands-on experience in ion trap, triple quadrupole, and time-of-flight mass spectrometry of small molecules as applied to environmental and pharmaceutical chemistry. She is currently a Professional Research Associate of the Center for Environmental Mass Spectrometry at the University of Colorado in Boulder, Colorado. She is the author of the book Liquid Chromatography/Mass Spectrometry, MS/MS and Time-of-Flight MS: Analysis of Emerging Contaminants. She is also the author of numerous highly cited papers on the analysis of pesticides and pharmaceuticals by liquid chromatography mass spectrometry.

E. Michael Thurman, PHD, is a highly cited scientist in environmental chemistry and an Emeritus Scientist with the U.S. Geological Survey. He is currently Director of the Center for Environmental Mass Spectrometry at the University of Colorado, in Boulder, Colorado. His bibliography consists of more than 200 publications in environmental chemistry, including more than 100 journal articles, twenty proceedings and chapters, and eighty U.S. Geological Survey publications. Dr. Thurman has published five books dedicated to the chemical analysis of pesticides and natural products, sample preparation, and mass spectrometry.

Preface	p. vii
Contributors	p. xi
Principles and Theoretical Aspects of Accurate Mass
Accurate Mass Measurements with Orthogonal Axis Time-of-Flight Mass Spectrometry	p. 3
The Mass Defect, Isotope Clusters, and Accurate Mass for Elemental Determination	p. 17
Tools for Unknown Identification Using Accurate Mass
Ion Compositions Determined with Increasing Simplicity	p. 35
Existence and Use of Accurate Mass Databases and Elemental Composition Tools for Target and Non-Target Analyses	p. 57
Use of UPLC-(Q)TOF MS for Rapid Screening of Organic Micropollutants in Water	p. 71
The Use of Accurate Mass, Isotope Ratios, and MS/MS for the Analysis of PPCPs in Water	p. 89
Applications of LC/TOF-MS for the Identification of Small Molecules
Applications of LC/TOF-MS in the Environmental Field: When did it Start and Where is it Going?	p. 105
Liquid Chromatography and Ambient Ionization Time-of-Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals	p. 113
Quantitative Analysis of Veterinary Drug Residues By Sub 2-¿m Particulate High-Performance Liquid Chromatography Columns and Time-of-Flight Mass Spectrometry (UPLC-TOF)	p. 133
Industrial Applications of Liquid Chromatography Time-of-Flight Mass Spectrometry	p. 151
Comprehensive Toxicological and Forensic Drug Screening by LC/TOF-MS	p. 173
Application of UPLC/TOF-MS for Residue Analysis of Veterinary Drugs and Growth-Promoting Agents in Products of Animal Origin	p. 197
Accurate Mass Measurements with a Reflectron Time-of-Flight Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for the Identification of Unknown Compounds Below Masses of 500 DA	p. 229
Comparison of LC/TOF-MS and LC/MS-MS for the Analysis of 100 Pesticides in Food: Finding the "Crossover Point"	p. 247
Index	p. 259
Table of Contents provided by Ingram. All Rights Reserved.

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Liquid Chromatography Time-of-Flight Mass Spectrometry Principles, Tools, and Applications for Accurate Mass Analysis

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