The Liver Biology and Pathobiology

, by Arias, Irwin; Wolkoff, Allan; Boyer, James; Shafritz, David; Fausto, Nelson; Alter, Harvey; Cohen, David

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ISBN: 9780470723135 | 0470723130
Cover: Hardcover
Copyright: 12/7/2009

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This new edition of the classic book for groups working in experimental and clinical hepatology continues its traditional strength of relating molecular physiology to understanding disease pathology and treatment. The editors are eminent scientists in the area of hepatology and each has an outstanding record.

List of Contributors
Preface
Acknowledgements
Introduction
Organizational Principles of the Liver
Embryonic Development of the Liver
The Cells
Microtubules, Actin Filaments and Motor-mediated Vesicular Transport
Molecular Motors
Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases
Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment
Endocytosis as an Essential Process in Liver Function and Pathology
Membrane Transport in Hepatocellular Secretion
Mitochondria
Nuclear Pore Complex
Protein Maturation and Processing at the Endoplasmic Reticulum
Protein Degradation and the Lysosomal System
Peroxisome Assembly, Degradation, and Disease
Gap and Tight Junctions in Liver: Composition, Regulation, and Function
Hepatocyte
Copper Metabolism and the Liver
The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis
Disorders of Bilirubin Metabolism
GH4.21. The porphyrias
Hepatic fatty acid metabolism and dysfunction
Lipoprotein Metabolism and Cholesterol Balance
Bile Secretion
Bile Acids and the Enterohepatic Circulation
Hepatocyte Basolateral Membrane Organic Anion Transporters
Nuclear Receptors Regulate Bile Acid Synthesis
GH4.27. Hormonal regulation of bile secretion
GH4.28. Nucleotide transport and regulation of bile formation
The Function of the Canalicular Membrane in Bile Formation and Secretion
Apical Recycling of Canalicular ABC Transporters
Cholangiocyte Functions in Health and Disease: The Ciliary Connection
Sinusoidal Cells
The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology
GH4.30. Endothelial and pit cells
Fenestrations in the Liver Sinusoidal Endothelial Cell
Hepatic Stellate Cells
Hepatic Fibrosis
Matrix
Interrelated Cell Functions
Insulin Resistance
Ca2+ Signaling in the Liver
GH4.35 Synthesis of and signalling through D-3 phosphoinositides
GH4.39. Nitric oxide in the liver
Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury
GH4.18. Hypoxic, Ischemic and reperfusion injury to liver
GH4.19. Protective mechanisms against reactive oxygen species
Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP
AMPK: Central Regulator of Glucose and Lipid Metabolism
GH3.16. Energy Metabolism
Liver Regeneration
GH4.40. Interleukin-6 signaling during the acute-phase response of the liver
GH4.43. Hepatocyte growth factor: its role in hepatic growth and pathobiology
Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver
GH4.5. Gene regulation and in vivo function of liver transcription factors
Liver Repopulation by Cell Transplantation and the Role of Stem Cells
Relation to Other Organs
Hepatic Encephalopathy
The Kidney in Liver Disease
Critical Role of the Liver in Coagulation
Pathobiological Analysis
Inheritable Cholestatic Disorders
GH4.48. Alpha 1-Antitrypsin deficiency
Adaptive Regulation of Hepatocyte Transporters in Cholestasis
Pathogenesis of Portal Hypertension
Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective
Pathophysiology of Alcoholic Liver Disease
Inflammation and Drug-induced Liver Injury
Hepatocyte Apoptosis
Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research
Molecular Biology of Hepatitis Viruses
Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis
GH4.41. Innate immune sensing and the toll-like receptors
Clinical Implications of the Molecular Biology of Hepatitis B Virus
Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection
Current and Future Therapy for Hepatitis B and C
Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced End-stage Liver Disease
Horizons
Tissue Engineering of the Liver
Aging and the Uncertain Roles of Sirtuins
The Liver Proteome
Liver-directed Gene Therapy
GH4.63. Novel strategies for manipulating hepatic gene expression in vivo
Decoding the Liver Cancer Genome
Genome-wide Expression Profiling of Human Hepatocellular Carcinoma
Cell Cycle Control in the Liver
miRNAs and Liver Biology
Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster
Zebrafish as a Model System for the Study of Liver Development and Disease
The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde
The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions
Telomeres and Aging, Cancer, and Hepatic Fibrosis
Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock Protein 47
The ôGreen Liver" and Transcriptional Regulation of Phase II Detoxification Genes
Index
Table of Contents provided by Publisher. All Rights Reserved.

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The Liver Biology and Pathobiology

Summary

Author Biography

Table of Contents

Supplemental Materials