Manual of Clinical Laboratory Immunology

, by Rose, Noel R.; Conway De Macario, Everly; Folds, James D.; Lane, H. Clifford; Nakamura, Robert M.

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ISBN: 9781555811181 | 1555811183
Cover: Hardcover
Copyright: 4/1/1997

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The much-awaited new edition of this classic reference manual features the latest on standard and cutting-edge immunological tests and procedures in clinical laboratory immunology. The best features of earlier editions have remained in this update, including a step-by-step interpretive approach to

Editorial Board

xiii

(2)

Contributors

(10)

Preface

xxv

PART I GENERAL METHODS

(444)

SECTION A IMMUNOLOGICAL METHODS

(72)

ROBERT M. NAKAMURA

ROBERT F. RITCHIE

1 Introduction

(2)

ROBERT F. RITCHIE

2 Agglutination Immunoassays

(6)

YASUSHI KASAHARA

3 Light-Scattering Immunoassays

(7)

FREDERICK VAN LENTE

4 Enzyme-Linked Immunoassays

(10)

A. BETTS CARPENTER

5 A Model System for Radioimmunoassays: Digoxin Reference Method

(9)

JAMES E. MYRICK

W. HARRY HANNON

6 Fluorescence Immunoassays

(10)

ROBERT M. NAKAMURA

DAVID J. BYLUND

7 Chemiluminescence Immunoassays

(5)

LARRY J. KRICKA

8 Immunofixation and Immunoblotting

(11)

THOMAS B. LEDUE

DAVID E. GARFIN

9 Clinical Indications for Electrophoresis and Immunofixation

(10)

DAVID F. KEREN

SECTION B MOLECULAR BIOLOGY METHODS

(56)

ROBERT M. NAKAMURA

VICTOR A. BERNSTAM

10 Introduction to Molecular Methodology

(31)

RAYMOND P. PODZORSKI

DEBRA L. KUKURUGA

P. MICHAEL LONG

11 Choosing Appropriate Methodologies in the Clinical Environment: Immunological Techniques versus Molecular Methods

108

(8)

A. BRADLEY EISENBREY

12 Keys to Successful In Situ PCR

116

(15)

GERARD J. NUOVO

SECTION C IMMUNOGLOBULIN METHODS

131

(46)

ROBERT M. NAKAMURA

ROBERT A. KYLE

13 Introduction

133

(1)

ROBERT A. KYLE

14 Immunoglobulin Quantitation

134

(13)

IRENE J. CHECK

CHRISTINE PAPADEA

15 Immunoglobulin Genes

147

(9)

LAURA Z. RASSENTI

THOMAS J. KIPPS

16 Immunochemical Characterization of Immunoglobulins

156

(21)

ROBERT A. KYLE

JERRY A. KATZMANN

SECTION D COMPLEMENT, IMMUNE COMPLEXES, AND CRYOGLOBULIN

177

(48)

JAMES D. FOLDS

PATRICIA C. GICLAS

17 Introduction

179

(2)

PATRICIA C. GICLAS

18 Complement Tests

181

(6)

PATRICIA C. GICLAS

19 Complement Activation

187

(5)

ARTHUR R. RABSON

20 Complement Receptors

192

(11)

V. MICHAEL HOLERS

21 Genetic Typing of the Complement System

203

(5)

JOANN M. MOULDS

22 Tests for Circulating Immune Complexes and Autoantibodies to C1q

208

(9)

MARK H. WENER

23 Cryoglobulins

217

(8)

PETER D. GOREVIC

DENNIS GALANAKIS

ALBERT F. FINN, JR.

SECTION E IMMUNE CELL PHENOTYPING AND FLOW CYTOMETRIC ANALYSIS

225

(48)

JAMES D. FOLDS

MICHAEL J. BOROWITZ

24 Introduction

227

(2)

MICHAEL J. BOROWITZ

25 Immunophenotyping by Flow Cytometry

229

(16)

PAMELA G. KIDD

JANET K. A. NICHOLSON

26 Functional Assays by Flow Cytometry

245

(10)

J. PAUL ROBINSON

WAYNE O. CARTER

PADMAKUMAR NARAYANAN

27 Flow Cytometric Analysis of DNA Content in Solid Tumors

255

(9)

LYNN G. DRESSLER

28 Emerging Clinical Applications of Flow Cytometry: Microbiology and Parasitology

264

(9)

HOWARD M. SHAPIRO

SECTION F IMMUNE CELL ASSAYS

273

(72)

JAMES D. FOLDS

MARY ANN FLETCHER

29 Introduction

275

(1)

MARY ANN FLETCHER

30 Delayed Hypersensitivity Skin Testing

276

(5)

NANCY KLIMAS

31 Cryopreservation of Peripheral Blood Mononuclear Cells

281

(6)

ROBERTO PATARCA

KEVIN MAHER

KARL GOODKIN

MARY ANN FLETCHER

32 T-Lymphocyte Activation

287

(9)

JOSEPH M. HASSETT

33 Cytolytic Cell Functions

296

(8)

ROBERTO PATARCA

MARY ANN FLETCHER

ECKHARD R. PODACK

34 Methods for Identification of the T-Cell Antigen Receptor

304

(9)

VIRGINIA LITWIN

SUSAN PLAEGER

35 Lymphocyte Proliferation

313

(7)

MARY ANN FLETCHER

ROBERT G. URBAN

DESHRATN ASTHANA

JEAN WALLING

ADAM FRIEDLANDER

J. BRYAN PAGE

36 Phagocytic Cell Functions. I. Oxidation and Chemotaxis

320

(9)

DONALD E. CAMPBELL

STEVEN D. DOUGLAS

37 Phagocytic Cell Functions. II. Adhesion and Phagocytosis

329

(5)

MAURICE R. G. O'GORMAN

38 Methods for Analysis of Apoptosis by Flow Cytometry

334

(11)

ZBIGNIEW DARZYNKIEWICZ

XUN LI

JIANPING GONG

FRANK TRAGANOS

SECTION G IMMUNE CELL PRODUCTS

345

(20)

JAMES D. FOLDS

JEFFREY L. ROSSIO

39 Introduction

347

(1)

JEFFREY L. ROSSIO

40 Cytokines and Immune Cell Products

348

(9)

JEFFREY L. ROSSIO

41 Development and Use of Cytokine and Growth Factor Potency Standards

357

(3)

CRAIG W. REYNOLDS

42 Measuring Cell Adhesion Molecules

360

(5)

JOHN M. CLEMENTS

ANDREW J. H. GEARING

SECTION H IMMUNOHISTOLOGY AND IMMUNOPATHOLOGY

365

(80)

ROBERT M. NAKAMURA

CLIVE R. TAYLOR

43 Introduction

367

(2)

CLIVE R. TAYLOR

44 Immunohistochemistry: Principles and Practice

369

(11)

CLIVE R. TAYLOR

SHAN RONG SHI

45 Immunohistochemistry in the Diagnosis of Solid Tumors

380

(9)

ANTHONY S. Y. LEONG

F. JOEL W. M. LEONG

46 Immunohistochemistry in the Diagnosis of Lymphomas

389

(11)

BRUCE A. ROBBINS

JOHN LEOPARD

KIRK Y. HIRATA

47 Prognostic Markers in Immunohistochemistry

400

(14)

RICHARD J. COTE

CLIVE R. TAYLOR

48 In Situ Hybridization as an Adjunct Method with Immunohistochemistry

414

(8)

JIANG GU

49 Immunofluorescence Methods for Diagnosis of Renal and Skin Diseases

422

(9)

A. BERNARD COLLINS

ROBERT B. COLVIN

HOSSEIN C. NOUSARI

GRANT J. ANHALT

50 Immunoelectron Microscopy in Diagnostic Pathology

431

(14)

ELBA A. TURBAT-HERRERA

LUALHATI E. HARKINS

GUILLERMO A. HERRERA

PART II IMMUNOLOGIC DIAGNOSIS AND MONITORING OF DISEASE

445

(708)

SECTION I INFECTIOUS DISEASES CAUSED BY BACTERIA, MYCOPLASMAS, CHLAMYDIAE, AND RICKETTSIAE

447

(124)

H. CLIFFORD LANE

ALBERTO J. L. MACARIO

51 Introduction

449

(1)

ALBERTO J. L. MACARIO

52 Immune Response to Streptococcal Antigens: Diagnostic Methods

450

(8)

ELIA M. AYOUB

ELAINE HARDEN

53 Haemophilus influenzae Type b, Neisseria meningitidis, Streptococcus pneumoniae, and Corynebacterium diphtheriae Vaccines

458

(12)

GEORGE M. CARLONE

JAY D. WENGER

BRADLEY A. PERKINS

SUSAN E. MASLANKA

TANJA POPOVIC

54 Clostridium tetani: Immune Response and Diagnostic Methods

470

(3)

MARTHA L. LEPOW

JOHN P. CRAIG

55 Immunologic Methods for Diagnosis of Infections by Gram-Negative Cocci

473

(11)

WENDELL D. ZOLLINGER

JOHN BOSLEGO

56 Immunologic Methods for Diagnosis of Infections Caused by Diarrheagenic Members of the Families Enterobacteriaceae and Vibrionaceae

484

(14)

GENEVIEVE A. LOSONSKY

MYRON M. LEVINE

57 Serodiagnosis of Helicobacter pylori Infection

498

(4)

BRUCE E. DUNN

58 Detection of Antibodies to Legionella spp.

502

(8)

PAUL H. EDELSTEIN

59 Immunologic Methods for Diagnosis of Spirochetal Diseases

510

(16)

VICTORIA POPE

SANDRA A. LARSEN

MARTIN SCHRIEFER

60 Lyme Disease: Serodiagnosis of Borrelia burgdorferi Sensu Lato Infection

526

(8)

RUSSELL C. JOHNSON

BARBARA J. B. JOHNSON

61 Immunological Procedures for Diagnosis of Tuberculosis and Leprosy

534

(9)

GRAHAM H. BOTHAMLEY

62 Nocardiae and Agents of Actinomycosis

543

(4)

BLAINE L. BEAMAN

63 Mycoplasma Infection: Immunologic and Molecular Biologic Diagnostic Techniques

547

(5)

STEPHEN G. BAUM

64 Chlamydiae

552

(6)

JULIUS SCHACHTER

65 Immunoserology of Rickettsiae

558

(13)

KARIM E. HECHEMY

SECTION J MYCOTIC AND PARASITIC DISEASES

571

(34)

H. CLIFFORD LANE

ERROL REISS

66 Introduction to Clinical Immunomycology and Clinical Immunoparasitology

573

(2)

ERROL REISS

67 Clinical Immunoparasitology

575

(10)

MARIANNA WILSON

PETER M. SCHANTZ

VICTOR C. W. TSANG

68 Clinical Immunomycology

585

(20)

LEO KAUFMAN

JOSEPH A. KOVACS

ERROL REISS

SECTION K VIRAL DISEASES

605

(156)

H. CLIFFORD LANE

STEVEN SPECTER

69 Introduction

607

(1)

STEVEN SPECTER

70 Rapid Viral Diagnosis

608

(10)

MARIE L. LANDRY

71 Antibody-Enhanced Detection of Viruses in Cell Cultures

618

(7)

THOMAS F. SMITH

72 Herpes Simplex Virus

625

(6)

JOHN A. STEWART

73 Varicella-Zoster Virus

631

(3)

PHILIP A. BRUNELL

74 Epstein-Barr Virus

634

(10)

HAL B. JENSON

YASMIN ENCH

CIRO V. SUMAYA

75 Cytomegalovirus

644

(5)

JOSEPH L. WANER

JOHN A. STEWART

76 Human Herpesvirus 6 and 7

649

(6)

RICHARD L. HODINKA

77 Papovaviruses

655

(6)

KEERTI V. SHAH

78 Adenoviruses

661

(6)

DEAN D. ERDMAN

JOHN C. HIERHOLZER

79 Parvovirus B19

667

(6)

YUORY V. KARETNYI

STANLEY J. NAIDES

80 Influenza Viruses

673

(6)

THEDI ZIEGLER

JACQUELINE M. KATZ

NANCY J. COX

HELEN L. REGNERY

81 Respiratory Syncytial Virus and the Parainfluenza Viruses

679

(9)

MAURICE A. MUFSON

ROBERT B. BELSHE

82 Measles and Mumps

688

(5)

FRANCIS L. BLACK

83 Rubella Virus

693

(6)

JAMES B. MAHONY

MAX A. CHERNESKY

84 Enteroviruses

699

(3)

JOSEPH L. MELNICK

85 Hepatitis Viruses

702

(17)

F. BLAINE HOLLINGER

GORDON R. DREESMAN

86 Enzyme Immunoassays for Detection of Rotavirus Antigen and Antibody

719

(10)

ROBERT H. YOLKEN

87 Arboviruses

729

(8)

THEODORE F. TSAI

GORU KUNO

88 Hantaviruses

737

(5)

STEPHEN A. YOUNG

89 Marburg Virus, Ebola Virus, and the Arenaviruses

742

(13)

PETER B. JAHRLING

90 Rabies Virus

755

(6)

D. CRAIG HOOPER

SECTION L HUMAN IMMUNODEFICIENCY VIRUS

761

(50)

H. CLIFFORD LANE

91 Introduction

763

(1)

H. CLIFFORD LANE

92 Immunologic Evaluation of Patients with Human Immunodeficiency Virus Infection

764

(9)

MICHAEL W. BASELER

RANDY A. STEVENS

LAURIE A. LAMBERT

JULIA A. METCALF

93 Quantitation of Viremia in Human Immunodeficiency Virus Infection by Viral RNA Estimation

773

(8)

V. NATARAJAN

D. WATERS

R. L. DEWAR

94 Isolation and Detection of Human Immunodeficiency Virus

781

(7)

T. ELBEIK

R. L. DEWAR

V. NATARAJAN

95 Principles and Procedures of Human Immunodeficiency Virus Serodiagnosis

788

(14)

M. B. VASUDEVACHARI

RICHARD T. DAVEY, JR.

JULIA A. METCALF

H. CLIFFORD LANE

96 Sequence Analysis of Human Immunodeficiency Virus Type 1 Haplotypes

802

(9)

C. CHAPPEY

H. IMAMICHI

N. P. SALZMAN

SECTION M IMMUNODEFICIENCY DISEASES

811

(54)

EVERLY CONWAY DE MACARIO

CHARLOTTE CUNNINGHAMRUNDLES

97 Introduction

813

(2)

CHARLOTTE CUNNINGHAM-RUNDLES

98 Genetics of Inherited Immunodeficiency Diseases and Diagnostic Techniques

815

(9)

CHRISTINE KINNON

ROLAND J. LEVINSKY

99 Combined B- and T-Cell Deficiencies

824

(5)

FRANCISCO A. BONILLA

RAIF S. GEHA

100 Investigation of Signal Transduction Defects

829

(6)

MELISSA E. ELDER

101 Primary Antibody Deficiencies in Children and Adults

835

(6)

ALEXANDER R. LAWTON

102 Inherited and Acquired C1-Inhibitor Deficiency

841

(4)

VIRGINIA H. DONALDSON

103 Genetically Determined Deficiencies of the Complement System: C1, C4, C2, and C3

845

(5)

JERRY A. WINKELSTEIN

ROHAN AMERATUNGA

104 Alternative Pathway and Late Complement Component Deficiencies

850

(5)

PETER DENSEN

105 Neutropenia and Neutrophil Defects

855

(10)

STEVEN M. HOLLAND

SECTION N ALLERGIC DISEASES

865

(52)

EVERLY CONWAY DE MACARIO

ROBERT G. HAMILTON

106 Introduction

867

(1)

ROBERT G. HAMILTON

107 Quantitation and Standardization of Allergens

868

(7)

JOHN W. YUNGINGER

MARK C. SWANSON

108 In Vivo Diagnostic Allergy Testing Methods

875

(6)

PHILIP S. NORMAN

R. STOKES PEEBLES

109 Immunological Tests for Diagnosis and Management of Human Allergic Disease: Total and Allergen-Specific IgE and Allergen-Specific IgG

881

(12)

ROBERT G. HAMILTON

N. FRANKLIN ADKINSON, JR.

110 Tests for Immunological Reactions to Drugs and Occupational Allergens

893

(6)

N. FRANKLIN ADKINSON, JR.

111 Assay Methods for Measurement of Mediators and Markers of Allergic Inflammation

899

(9)

JOHN T. SCHROEDER

ANNE KAGEY-SOBOTKA

112 Immunological Tests for Evaluation of Hypersensitivity Pneumonitis and Allergic Bronchopulmonary Aspergillosis

908

(9)

VISWANATH P. KURUP

JORDAN N. FINK

SECTION O SYSTEMIC AUTOIMMUNE DISEASES

917

(52)

NOEL R. ROSE

ENG M. TAN

113 Introduction

919

(1)

ENG M. TAN

114 Immunofluorescent Antinuclear Antibody Tests

920

(8)

MARVIN J. FRITZLER

115 Detection of Autoantibodies to Ribonucleoprotein Particles by Immunoblotting

928

(7)

EDWARD K. L. CHAN

K. MICHAEL POLLARD

116 Enzyme-Linked Immunosorbent Assays for Antibodies to Native DNA, Histones, and (H2A-H2B)-DNA

935

(7)

ROBERT L. RUBIN

117 Rheumatoid Factors

942

(7)

MARK H. WENER

MART MANNIK

118 Antiphospholipid Antibodies

949

(5)

AZZUDIN E. GHARAVI

MICHAEL D. LOCKSHIN

119 Antineutrophil Cytoplasmic Antibodies

954

(6)

ALLAN WIIK

120 Autoantibodies to Complement Components

960

(9)

PATRICIA C. GICLAS

JEFFREY J. WISNIESKI

SECTION P ORGAN-LOCALIZED AUTOIMMUNE DISEASES

969

(62)

NOEL R. ROSE

PIERLUIGI E. BIGAZZI

121 Introduction

971

(1)

PIERLUIGI E. BIGAZZI

122 Endocrinopathies

972

(11)

P. E. BIGAZZI

C. L. BUREK

N. R. ROSE

MARGITA ZAKARIJA

J. MAXWELL McKENZIE

CLIVE H. WASSERFALL

NOEL K. MACLAREN

123 Detection of Autoantibodies in Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

983

(6)

GUY E. GRIESMANN

VANDA A. LENNON

124 Detection of Antimitochondrial Autoantibodies in Primary Biliary Cirrhosis and Liver-Kidney Microsomal Antibodies in Autoimmune Hepatitis

989

(8)

PATRICK S. C. LEUNG

MICHAEL P. MANNS

ROSS L. COPPEL

M. ERIC GERSHWIN

125 Skin Diseases

997

(8)

HOSSEIN C. NOUSARI

GRANT J. ANHALT

126 Cardiovascular Diseases

1005

(3)

NOEL R. ROSE

C. LYNNE BUREK

127 Kidney and Lung Disease Mediated by Glomerular Basement Membrane Antibodies: Detection by Western Blot Analysis

1008

(5)

A. BERNARD COLLINS

ROBERT B. COLVIN

128 Human Spermatozoa Antibodies: Detection and Clinical Significance

1013

(5)

RICHARD A. BRONSON

KENNETH S. K. TUNG

129 Autoimmune Hemolytic Anemias

1018

(8)

LAWRENCE D. PETZ

130 Autoimmune Thrombocytopenia

1026

(5)

THOMAS S. KICKLER

SECTION Q CANCER

1031

(44)

EVERLY CONWAY DE MACARIO

THERESA L. WHITESIDE

131 Introduction

1033

(2)

THERESA L. WHITESIDE

132 Human Tumor Antigens Recognized by T Lymphocytes

1035

(6)

HARRY D. BEAR

133 Cancer Vaccines

1041

(7)

LOUIS D. FALO, JR.

MICHAEL T. LOTZE

134 Cancer Genes and Early Cancer Detection

1048

(7)

ROBERT E. FERRELL

WENDY S. RUBINSTEIN

135 Malignancies of the Lymphoid and Histiocytic Systems

1055

(10)

ELAINE S. JAFFE

MARK RAFFELD

136 Monitoring of Immunologic Therapies

1065

(10)

THERESA L. WHITESIDE

JACQUELYN A. HANK

SECTION R TRANSPLANTATION IMMUNOLOGY AND IMMUNOGENETICS

1075

(78)

EVERLY CONWAY DE MACARIO

MARY S. LEFFELL

137 Introduction: Genes in the Human Major Histocompatibility Complex Relevant to Immune Regulation and Transplantation and Other Clinical Applications

1077

(3)

MARY S. LEFFELL

138 Histocompatibility Testing by Immunologic Methods: Cellular Assays

1080

(7)

NANCY L. REINSMOEN

139 Histocompatability Testing by Immunologic Methods: Humoral Assays

1087

(11)

CALVIN D. LOU

KELLY J. CUNNIFFE

MARVIN R. GAROVOY

140 HLA Typing by Molecular Methods

1098

(14)

CAROLYN KATOVICH HURLEY

TING TANG

JENNIFER NG

ROBERT J. HARTZMAN

141 Guidelines for Use of Immunogenetic Tests in Organ Transplantation

1112

(5)

EDGAR L. MILFORD

NALAN UTKU AMAC

142 Immunological Characterization of Solid Organ Graft Recipients

1117

(6)

MANIKKAM SUTHANTHIRAN

MARVIN R. GAROVOY

TERRY B. STROM

143 Histocompatibility Assessment in Bone Marrow Transplantation

1123

(9)

PATRICK G. BEATTY

144 Statistical Analysis and Applications of HLA Population Data

1132

(9)

ANDREA A. ZACHARY

ARTHUR G. STEINBERG

145 Principles and Applications of Genetic Identification

1141

(12)

ANDREA A. ZACHARY

WILMA B. BIAS

CHARLOTTE J. WORD

PART III ADMINISTRATION

1153

(70)

SECTION S LABORATORY MANAGEMENT

1155

(68)

NOEL R. ROSE

DAVID F. KEREN

146 Introduction

1157

(1)

DAVID F. KEREN

147 Establishment and Verification of Reference Values

1158

(10)

EARLE W. HOLMES

148 Standardization of Immunoassay Methodologies

1168

(12)

CAROLYN S. FELDKAMP

JOHN L. CAREY

149 Quality Assurance

1180

(11)

PETER J. HOWANITZ

JOAN H. HOWANITZ

150 Planning Statistical Quality Control Procedures

1191

(10)

JAMES O. WESTGARD

151 Interlaboratory Proficiency Testing in Laboratory Immunology

1201

(5)

HENRY A. HOMBURGER

MARY L. PATON

152 Clinical Significance and Cost-Effectiveness of Clinical Immunology Testing

1206

(7)

DAVID F. KEREN

VICTOR A. HRUSZCZYK

153 Laboratory Safety

1213

(10)

PAUL N. VALENSTEIN

MARGARET L. COLLINGE

Author Index

1223

(2)

Subject Index

1225

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Manual of Clinical Laboratory Immunology

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