Mass Spectrometry in Drug Metabolism and

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

MIKE S. LEE, PhD, is President of Milestone Development Services. His recent work has involved the development of automated orthogonal control systems for electrospray ionization. Formerly, Dr. Lee was director of analytical research and development at Bristol-Myers Squibb (BMS) Pharmaceutical Research Institute where he led interdisciplinary teams that contributed to the Food and Drug Administration's approval of Buspar® and Serzone®, and the accelerated development and approval of Taxol®. In addition, he has authored over forty scientific papers and issued patents.

MINGSHE ZHU, PhD, is a drug metabolism researcher at Bristol-Myers Squibb, where he leads a team that investigates biotransformation in new drug discovery and preclinical drug metabolism and pharmacokinetics in development. His teams have provided key metabolism and disposition information for regulatory approval of Abilify® and NDA submission of Dapagliflozin. Dr. Zhu's research interests include LC/MS technology, optimization of ADME properties, metabolic activation, and regulatory drug metabolism. He has been frequently invited to speak and teach short courses at conferences/workshops and has coauthored over sixty research articles and one book.

Foreword
Preface
Contributors
Basic Concepts of Drug Metabolism and Disposition
Progression of Drug Metabolism
Common Biotransformation Reactions
Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry
Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions
Experimental Models of Drug Metabolism and Disposition
Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery
Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes
Mass Spectrometry in Drug Metabolism: Principles and Common Practice
Theory and Instrumentation of Mass Spectrometry
Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification
Mass Spectral Interpretation
Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection
Applications of New LC-MS Techniques in Drug Metabolism and Disposition
Quantitative In Vitro ADME Assays Using LC-MS as a Part of Early Drug Metabolism Screening
High-Resolution Mass Spectrometry and Drug Metabolite Identification
Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging
Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC-MS Platform in Drug Metabolism and Pharmacokinetics
Quantitative Drug Metabolism with Accelerator Mass Spectrometry
Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions
Profiling and Characterization of Herbal Medicine and Its Metabolites Using LC-MS
Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices
Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress
LC-MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery
Appendix
Index.
Table of Contents provided by Publisher. All Rights Reserved.

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Mass Spectrometry in Drug Metabolism and Disposition Basic Principles and Applications

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