Mass Spectrometry of Nucleosides and Nucleic Acids

Nucleic acid research has had a profound impact on molecular biology, resulting in a variety of new disciplines. Mass Spectrometry of Nucleosides and Nucleic Acids puts into perspective the progress in biotechnological research developed over the last few decades. This book provides an overview of the most popular ionization methods, often used in conjunction with tandem mass spectrometry. The text illustrates the diversity of strategies used in the characterization and sequencing of simple nucleosides and nucleotides, covering complex DNA, single strands and duplexes, DNA adducts, RNA oligomers, DNA drug complexes, and posttranscriptional modifications, among other topics.