Membrane Microdomain Signaling

Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Annette Brand: Department of Pediatrics, Georgetown University, Washington, DC Elke Burgermeister: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Jessica L. Crowley: Cell Dynamics Group, Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA Roy G. Cutler: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD Markus Delling: Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, MA Christopher J. Fielding: Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA Norman J. Haughey: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD Neeru Jain: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Mordechai Liscovitch: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Elizabeth J. Luna: Cell Dynamics Group, Department of Cell Biology, University of Massachusetts Medical School, Worcester Janos Matko: Department of Immunology, Eotvos Lorand University, Budapest, Hungary Mark P. Mattson: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD Thomas Nebl: Cell Dynamics Group, Department of Cell Biology, University of Massachusetts Medical School, Worcester Wu Ou: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD Dana Ravid: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Melitta Schachner: Zentrum fur Molekulare Neurobiologie, University of Hamburg, Germany Maria Shatz: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Jonathan Silver: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD Janos Szollosi: Cell Biophysics Research Group of the Hungarian Academy of Sciences, Department of Biophysics and Cell Biology, Health Science Center, University of Debrecen, Debrecen, Hungary Norio Takizawa: Cell Dynamics Group, Department of Cell Biology, University of Massachusetts Medical School, Worcester Lilach Tencer: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel Wim J. van Blitterswijk: Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam Arnold H. van der Luit: Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam Marcel Verheij: Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam Ephraim Yavin: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD and Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel