Metabolic Polymorphisms and Susceptibility to Cancer

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Metabolic Polymorphisms and Susceptibility to Cancer by Paolo Vineis; Núria Malats; Matti Lang; Angelo d'Errico; Neil Caporaso, 9789283221487
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  • ISBN: 9789283221487 | 9283221486
  • Cover: Paperback
  • Copyright: 8/12/1999

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The study of interactions between genes and environmental exposures ha s expanded considerably in recent years. Highly penetrant genes that a re involved in familial cancer have been identified, but are likely to account for a relatively small proportion of total cancers. Other pre disposing genes have low penetrance, resulting in a moderate increase in the risk of specific cancers, but are widespread in the general pop ulation. This is the case for so-called metabolic polymorphisms. Scien tific interest in metabolic polymorphisms is based on the possibility of identifying subgroups of the population which are at elevated risk of developing environmentally-induced cancer. However, such studies ra ise a series of problems that are methodological - related to the stud y design and analysis - and ethical - related to the practical use tha t can be made of genetic information. This volume deals thoroughly wit h such problems.
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