Metabolism and Bacterial Pathogenesis

Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis

For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments.

Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future.

Beginning with overviews, Metabolism and Bacterial Pathogenesis covers

• a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations
• intracellular, respiratory, and enteric pathogens
• pathogen-specific nutrient acquisition in hosts
• mechanisms of host-driven metabolic adaptation by pathogens
• metabolic regulation of virulence gene expression

Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.

1 Glycolysis for the Microbiome Generation

2 Pathogenesis - Thoughts from the Front Line

3 Metabolic Adaptations of Intracellullar Bacterial Pathogens and their Mammalian Host Cells during Infection ("Pathometabolism")

4 Small RNAs Regulate Primary and Secondary Metabolism in Gram-negative Bacteria

5 Sialic acid and N-acetylglucosamine Regulate type 1 Fimbriae Synthesis

6 Trigger Enzymes: Coordination of Metabolism and Virulence Gene Expression

7 Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria

8 Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle

9 Metabolism and Pathogenicity of Pseudomonas aeruginosa Infections in the Lungs of Individuals with Cystic Fibrosis

10 Metabolism and Fitness of Urinary Tract Pathogens

11 Bacterial Metabolism in the Host Environment: Pathogen Growth and Nutrient Assimilation in the Mammalian Upper Respiratory Tract

12 Saliva as the Sole Nutritional Source in the Development of Multispecies Communities in Dental Plaque

13 Enteric Pathogens Exploit the Microbiota-generated Nutritional Environment of the Gut

14 The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection

15 Host Sialic Acids: A Delicacy for the Pathogen with Discerning Taste

16 Commensal and Pathogenic Escherichia coli Metabolism in the Gut

Index

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