Metal Ions in Biological Systems: Volume 19:

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Preface to the Series	p. iii
Preface to Volume 19	p. v
Contributors	p. xiii
Contents of Other Volumes	p. xv
The Discovery of Ionophores: An Historical Account	p. 1
Abbreviations	p. 16
References	p. 17
Tetracyclines and Daunorubicin	p. 19
Introduction	p. 19
Tetracyclines	p. 20
Daunorubicin	p. 40
References	p. 49
Interaction of Metal Ions with Streptonigrin and Biological Properties of the Complexes	p. 53
Introduction	p. 54
Structural and Chemical Properties of Streptonigrin and Its Metal Complexes	p. 55
Biological Activity and Suggested Mechanistic Schemes for the Antitumor Action of Streptonigrin	p. 70
Conclusions	p. 76
References	p. 77
Bleomycin Antibiotics: Metal Complexes and Their Biological Action	p. 81
Introduction	p. 82
Structural and Synthetic Aspects of Bleomycin	p. 82
Characteristics of Bleomycin-Metal Complexes	p. 85
Oxygen Activation and Redox Cycle of the Bleomycin-Iron Complex	p. 85
Interaction of Bleomycin and Its Iron Complex with DNA	p. 90
Sequence-Specific DNA Cleavage by the Bleomycin-Iron Complex	p. 92
Metal Complexes and DNA Cleavage of Bleomycin Analogs: Peplomycin, Tallysomycin, and Phleomycin	p. 95
Metal Complexes and Oxygen Activation by Synthetic Analogs and Biosynthetic Intermediates of Bleomycin	p. 97
Molecular Mechanism of Bleomycin Action	p. 103
Conclusions	p. 104
References	p. 105
Interaction Between Valinomycin and Metal Ions	p. 109
Introduction	p. 110
Structure and Conformation of Free Valinomycin	p. 112
Structure and Conformation of Valinomycin-Metal Ion Complexes	p. 115
Valinomycin-Metal Ion Complexes in Transmembrane Ion Transport	p. 131
Abbreviations and Definitions	p. 132
References	p. 133
Beauvericin and the Other Enniatins	p. 139
Introduction	p. 140
Ion Binding	p. 143
Membrane Transport	p. 158
Analogs	p. 165
Conclusions	p. 167
Abbreviations	p. 167
References	p. 168
Complexing Properties of Gramicidins	p. 173
Introduction	p. 174
Structural Properties	p. 175
Ion-Complexing Properties	p. 186
Transport Properties	p. 193
References	p. 200
Nactins: Their Complexes and Biological Properties	p. 207
Introduction	p. 207
Molecular Structure of Nactins	p. 209
Complexes	p. 212
Biological Properties	p. 224
References	p. 225
Cation Complexes of the Monovalent and Polyvalent Carboxylic Ionophores: Lasalocid (X-537A), Monensin, A23187 (Calcimycin), and Related Antibiotics	p. 229
Introduction	p. 230
Structure of Ionophore-Cation Inclusion Complexes	p. 233
Techniques for Measuring Equilibrium Ionophore-Ion Affinities	p. 239
Carboxylic Ionophore-Mediated Ion Transport	p. 248
Biological Test Systems	p. 266
Conformational Aspects of Ion Capture and Membrane Transport	p. 272
Biological Applications of Ionophores	p. 284
Overview	p. 288
References	p. 289
Complexes of D-Cycloserine and Related Amino Acids with Antibiotic Properties	p. 295
Introduction	p. 295
Mode of Action	p. 297
Uses of D-Cycloserine	p. 298
Organic Chemistry of D-Cycloserine	p. 300
Metal Ion Coordination by D-Cycloserine	p. 301
Metal Ion Coordination by D-Cycloserine Derivatives	p. 307
Conclusions	p. 308
Abbreviations	p. 309
References	p. 310
Iron-Containing Antibiotics	p. 313
Introduction	p. 314
Iron(III) Complexes	p. 320
Iron(II) Complexes	p. 324
Miscellaneous Compounds	p. 327
General Conclusions	p. 329
References	p. 330
Cation-Ionophore Interactions: Quantification of the Factors Underlying Selective Complexation by Means of Theoretical Computations	p. 335
Introduction	p. 336
Outline of the Methodology	p. 337
Selective Binding of Alkali Cations by Valinomycin	p. 342
Selective Complexation of K[superscript +], Na[superscript +], and NH[superscript + subscript 4] by Nonactin	p. 347
Selective Binding of Mg[superscript 2+] and Ca[superscript 2+] by Ionophore A23187	p. 354
Structural Properties of Valinomycin and A23187	p. 364
Energy Profiles for Single and Double Occupancy by Na[superscript +] of the Gramicidin A Channel	p. 374
Conclusions	p. 379
Abbreviations	p. 380
References	p. 381
Author Index	p. 387
Subject Index	p. 411
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Metal Ions in Biological Systems: Volume 19: Antibiotics and Their Complexes

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