Microencapsulation: Methods and Industrial Applications, Second Edition

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ISBN: 9780824723170 | 0824723171
Cover: Hardcover
Copyright: 11/1/2005

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Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.

Preface to the Second Edition

iii

Preface to the First Edition

Contributors

PART I: METHODS OF ENCAPSULATION AND ADVANCES IN PRODUCTION TECHNOLOGY

Biodegradable Microspheres: Advances in Production Technology

(54)

Frederic Tewes

Frank Boury

Jean-Pierre Benoit

Introduction

(1)

Techniques Using Organic Solvents

(6)

Techniques Without Organic Solvents

(33)

References

(14)

Advances in the Technology for Controlled-Release Pesticide Formulations

(24)

Arie Markus

Charles Linder

Introduction

(4)

Standard Microencapsulation Processes for Pesticides

(8)

Advances in Encapsulation Technologies

(4)

Quality Control

(4)

Case Study: De-Bugger®

(1)

Summary

(1)

References

(3)

Multiparticulate Pulsatile Drug Delivery Systems

(20)

Till Bussemer

Roland Bodmeier

Introduction

(4)

Pulsatile Systems

(1)

Site-Specific Systems

(2)

Time-Controlled Pulsatile Systems

(1)

Multiparticulate Systems

(7)

Outlook

(1)

References

(5)

Microencapsulation Techniques for Parenteral Depot Systems and Their Application in the Pharmaceutical Industry

(24)

Thomas Kissel

Sascha Maretschek

Claudia Packhauser

Julia Schnieders

Nina Seidel

Introduction

(1)

Biodegradable Polymers

100

(3)

Phase Separation and Coacervation

103

(3)

W/O/W-Double Emulsion Technique

106

(7)

Spray Drying

113

(5)

Conclusion

118

(1)

References

118

(5)

Coupling Methods to Obtain Ligand-Targeted Liposomes and Nanoparticles

123

(26)

Leila Bossy-Nobs

Franz Buchegger

Robert Gurny

Eric Allemann

Introduction

123

(1)

Liposomal Modification Techniques

124

(14)

Labeling Polymeric Nanoparticles with Ligands

138

(3)

How to Choose the Coupling Method

141

(1)

Concluding Remarks

142

(1)

References

142

(7)

Industrial Technologies and Scale-Up

149

(34)

Francois Puel

Stephanie Briancon

Hatem Fessi

Introduction

149

(3)

Emulsification Processes

152

(12)

Scale-Up Approach: The Case of Emulsification

164

(3)

Applications---Examples

167

(11)

Summary

178

(1)

Notations

178

(1)

References

179

(4)

PART II: EVALUATION AND CHARACTERIZATION OF MICRO- AND NANOPARTICULATE DRUG DELIVERY SYSTEMS

Drug Release from Microparticulate Systems

183

(30)

Shicheng Yang

Clive Washington

Introduction

183

(1)

Measurement of Drug Release

183

(3)

Mechanisms of Drug Release

186

(2)

Drug Release Kinetic Models

188

(10)

Empirical Models and Comparison of Drug Release Profiles

198

(5)

In Vitro-In Vivo Correlation

203

(1)

Summary

204

(1)

References

205

(8)

Manufacture, Characterization, and Applications of Solid Lipid Nanoparticles as Drug Delivery Systems

213

(56)

Heike Bunjes

Britta Siekmann

Introduction: The Rationale of Using Biodegradable, Nanoparticulate Solid Lipids in Drug Delivery

213

(3)

Manufacturing Methods for Lipid Nanoparticle Suspensions

216

(14)

Physicochemical Characterization of Colloidal Lipid Suspensions and Nanoparticles

230

(12)

Applications in Drug Delivery

242

(13)

Conclusions

255

(2)

References

257

(12)

Amphiphilic Cyclodextrins and Microencapsulation

269

(28)

Erem Memisoglu-Bilensoy

A. Atilla Hincal

Amelie Bochot

Laury Trichard

Dominique Duchene

Introduction

269

(1)

Cyclodextrins and Derivatives

270

(8)

Amphiphilic Cyclodextrin Nanoparticles

278

(13)

Conclusion

291

(1)

References

291

(6)

Lipospheres for Controlled Delivery of Substances

297

(20)

Abraham J. Domb

Introduction

297

(1)

Preparation of Lipospheres

298

(1)

Physical Characterization of Lipospheres

299

(3)

Applications of Lipospheres

302

(12)

Summary

314

(1)

References

315

(2)

Pharmaceutical Aspects of Liposomes: Academic and Industrial Research and Development

317

(28)

Rimona Margalit

Noga Yerushalmi

Introduction

317

(1)

Liposomes: Definition, Needs for, and Outline of their Advantages and Drawbacks

318

(5)

Selection of the Liposome Type/Species: Views and Criteria from Academic and Industrial Research and Their Proposed Integration

323

(3)

Targeted/Modified Liposomes: An Interesting and Exciting Scientific Tool, But Can They Be Made into Products (Especially Immunoliposomes)?

326

(4)

Liposomes as a Sterile, Pyrogen-Free System with Pharmaceutically Acceptable Shelf-Life, Stability, and Dosage Forms

330

(3)

Liposome Characteristics (Percentage of Encapsulation, Kinetics of Release, Biological Activity) In Basic Research and in Quality Assurance

333

(7)

Summary and Prospects

340

(1)

References

340

(5)

Microemulsions for Solubilization and Delivery of Nutraceuticals and Drugs

345

(84)

Nissim Garti

Abraham Aserin

The Rationale

345

(3)

Microemulsions as Nanovehicles

348

(1)

Part I---Microemulsion Preparation and Microstructures

349

(36)

Part II---Potential Applications

385

(29)

Final Remarks

414

(2)

References

416

(13)

PART III: APPLICATIONS OF PARTICULATE DELIVERY SYSTEMS

Self-Emulsifying Oral Lipid-Based Formulations for Improved Delivery of Lipophilic Drugs

429

(52)

Jean-Sebastien Garrigue

Gregory Lambert

Simon Benita

Definition

429

(1)

Introduction

430

(1)

Drug Delivery Issues

430

(3)

Composition of SEDDS

433

(11)

Characterization of SEDDS

444

(4)

Biopharmaceutical Aspects

448

(18)

The Story of Oral Cyclosporin A

466

(2)

The Oral Paclitaxel Challenge

468

(1)

Future and Prospects

469

(1)

References

470

(11)

Recent Advances in Heparin Delivery

481

(40)

Nathalie Ubrich

Philippe Maincent

Introduction

481

(1)

Blood and Mechanism of Action of Heparins

482

(1)

Evaluation of Heparin Efficiency

483

(1)

Oral Delivery of Heparins

483

(33)

Conclusion

516

(1)

References

516

(5)

Particulate Systems for Oral Drug Delivery

521

(42)

Maria Jose Blanco-Prieto

Florence Delie

Introduction

521

(1)

Absorption of Polymeric Particulates from the GI Tract

522

(5)

Use of Polymeric Particles for Oral Administration

527

(25)

Conclusions

552

(1)

References

553

(10)

Vesicles as a Tool for Dermal and Transdermal Delivery

563

(24)

P. L. Honeywell-Nguyen

J. A. Bouwstra

Dermal and Transdermal Drug Delivery

563

(1)

The Skin Barrier Function

564

(2)

Vesicles as Skin Delivery Systems

566

(6)

Elastic Vesicles

572

(8)

References

580

(7)

Lipid and Polymeric Colloidal Carriers for Ocular Drug Delivery

587

(38)

Simon Benita

S. Tamilvanan

Introduction

587

(2)

Topically Treated Ocular Pathologies

589

(5)

Lipid and Polymeric Colloidal Carriers: Description and Classification

594

(2)

O/W Submicron Emulsions

596

(9)

Microemulsions

605

(2)

Multiple Emulsions

607

(1)

Nanoparticles

608

(6)

Nanocapsules

614

(3)

Future Directions in Ocular Drug Delivery Using Lipid and Polymeric Colloidal Carriers

617

(1)

References

617

(8)

The Use of Drug-Loaded Nanoparticles in Cancer Chemotherapy

625

(48)

Jean-Christophe Leroux

Angelica Vargas

Eric Doelker

Robert Gurny

Florence Delie

Introduction

625

(1)

In Vitro Uptake of NP by Tumoral Cells

626

(13)

Distribution and Pharmacokinetics of Anticancer Drugs Coupled to NP

639

(11)

In Vivo Activity and Toxicity of Anticancer Drugs Coupled to NP

650

(11)

Concluding Remarks

661

(1)

References

662

(11)

Development of 5-FU-Loaded PLGA Microparticles for the Treatment of Glioblastoma

673

(16)

Nathalie Faisant

Jean-Pierre Benoit

Philippe Menei

Introduction

673

(1)

Microsphere Formulation and Development

674

(4)

Preclinical Trials

678

(4)

Application to Glioma Therapy After Tumor Resection: Phase I--II and IIB Studies

682

(2)

Stereotaxic Implantation in Malignant Glioma: Phase I Study

684

(1)

Conclusion

685

(1)

References

686

(3)

Nanoparticles as Drug Delivery Systems for the Brain

689

(18)

Jorg Kreuter

Introduction

689

(1)

Drug Delivery to the Brain with Nanoparticles

690

(7)

Long Circulating Nanoparticles for Brain Drug Delivery

697

(2)

Stability of Nanoparticles for Brain Delivery Upon Storage

699

(1)

Mechanism of Nanoparticle-Mediated Drug Transport to the Brain

699

(3)

Conclusions

702

(1)

References

703

(4)

Cosmetic Applications of Colloidal Delivery Systems

707

(42)

Simon Benita

Marie-Claude Martini

Anne-Marie Orecchioni

Monique Seiller

Introduction

707

(1)

Types of Vesicular Delivery Systems

708

(7)

Composition

715

(5)

Production

720

(7)

Characterization

727

(4)

Stability

731

(1)

Cosmetic Uses

732

(9)

Conclusion

741

(1)

References

741

(8)

Index

749

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Microencapsulation: Methods and Industrial Applications, Second Edition

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Microencapsulation: Methods and Industrial Applications, Second Edition

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