Mobile DNA Finding Treasure in Junk

InMobile DNA, leading geneticist Haig Kazazian thoroughly reviews our current understanding of the substantial role mobile genetic elements play in genome and organism evolution and function. He offers an accessible intellectual history of mobile DNA, rich and insightful perspectives on how investigators ask and answer research questions, and his predictions about future developments and research directions for this active field.

Haig H. Kazazian, Jr. is Professor at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University School of Medicine. He previously served as chair of the Department of Genetics and Seymour Gray Professor of Molecular Medicine in Genetics at the University of Pennsylvania School of Medicine.

Preface: Thoughts on Doing Science	p. xii
Introduction to Mobile DNA	p. 1
Varieties of Mobile DNA	p. 5
DNA Transposons	p. 19
Mobile DNA of Model Organisms	p. 29
Exceptional Scientists Working on Mobile DNA in Lower Organisms	p. 35
Role of Bioinformatics in Genome Analysis	p. 43
The Prologue	p. 49
ôWelcome to the Wonderful World of LINEsö	p. 59
An Experimental Breakthrough	p. 73
Reverse Transcriptase to the Rescue	p. 81
A Quirk of L1 Elements-A Lousy 3' End Is Important for Genome Evolution	p. 85
A Tour de Force from Tom Eickbush	p. 89
ôI don't believe all those colonies represent retrotransposition events.ö	p. 93
L1 Encodes an Endonuclease	p. 101
The Jocks	p. 105
The Mayor and the Frenchman	p. 115
Ostertag's Coups	p. 121
The Independent Canadian	p. 133
The Musician Scientist	p. 141
Young Ladies in the Back Bay	p. 145
The Brilliant Young Lady from China	p. 157
Hiroki's Big Surprises	p. 163
A Young Man with a Purpose	p. 173
Other Mobile DNA in Mammalian Genomes	p. 179
Effects of Retrotransposons on Mammalian Genomes	p. 187
Host Factors Involved in L1 Retrotransposition	p. 201
Why Mobile DNA?	p. 207
The Future of Mobile DNA Research	p. 209
Predictions for Mobile DNA	p. 221
References	p. 225
Glossary	p. 249
Index	p. 255
Table of Contents provided by Ingram. All Rights Reserved.

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Mobile DNA Finding Treasure in Junk

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Author Biography

Table of Contents

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