Modern Heterocyclic Chemistry, 4 Volumes

Since vitamins, hormones, antibiotics, pharmaceuticals, dyes and many other products all contain heterocycles, they play an important role in our everyday life. The must-have reference in the field of heterocyclic compounds, comprehensively covering their synthesis, structure and chemical and physical properties in four volumes. It presents a wealth of information but stays userfriendly by focussing on the important facts. An up-to-date source of high-quality information for all organic and medicinal chemists working in this field in industry and academia.

Julio Alvarez-Builla received his PhD at the University Complutense and spent a postdoc stage with Professor A.R. Katritzky at the University of East Anglia. At present he is full professor of Organic Chemistry at the Faculty of Pharmacy of the University of Alcal?. He has strong interests in collaborating with Pharmaceutical industry, and in relation with that he has been the scientific director of the University's fine chemicals pilot plant facility from 1998 to 2008. His research interests include the chemistry of azinium N-ylides and N-aminides, the chemistry of nitrogen bridgehead heterocycles, and the synthesis of heterocyclic pharmaceutical products.

Juan J. Vaquero received his degree in Chemistry from the Complutense University (Madrid) and the PhD degree in Organic Chemistry from the University of Alcal?. He was a NATO postdoctoral fellow with Professor Charles W. Rees at the Imperial College (London). In 1987, he joined the Department of Organic Chemistry of the University of Alcal? where he is a Full Professor Organic Chemistry. He acted as the Dean of the Faculty of Chemistry (2000-2006). His research interests include the chemistry of azonia heterocyclic systems, the synthesis of bioactive compounds targeting DNA and the total synthesis of natural alkaloids.

Jos? Barluenga holds the chair of Organic Chemistry at the University of Oviedo, where he founded the Instituto Universitario de Qu?mica Organomet?lica "Enrique Moles" and is currently developing his research. During his career, Professor Barluenga has published more than 615 research articles and he has been the recipient of many awards including the Research Award of the "Alexander von Humboldt" Foundation, FRG (1989, First Edition), the Solvay Award from Spanish CEOE (1990), the 1st Spain Dupont Award, the Iberdrola Award for Science and Technology (1996), the Gold Medal from the Spanish Society of Chemistry (1999), the "Enrique Moles" National Award of Chemical Science and Technology from the Ministry of Education and Science (2001, First Edition) and the Rey Jaime I Award for Basic Research (2005).

List of Contributors XVII

Volume 1

1. Heterocyclic Compounds: An Introduction 1
Julio Alvárez-Builla and José Barluenga

2. Three-Membered Heterocycles. Structure and Reactivity 11
S. Shaun Murphree

3. Four-Membered Heterocycles: Structure and Reactivity 163
Gérard Rousseau and Sylvie Robin

4. Five-Membered Heterocycles: Pyrrole and Related Systems 269
Jan Bergman and Tomasz Janosik

5. Five-Membered Heterocycles: Indole and Related Systems 377
José Barluenga and Carlos Valdés

6. Five-Membered Heterocycles: Furan 533
Henry N. C. Wong, Xue-Long Hou, Kap-Sun Yeung, and Hui Huang

7. Five-Membered Heterocycles: Benzofuran and Related Systems 593
Jie Wu

Volume 2

8. Five-Membered Heterocycles: 1,2-Azoles. Part 1. Pyrazoles 635
José Elguero, Artur M. S. Silva, and Augusto C. Tomé

9. Five-Membered Heterocycles: 1,2-Azoles. Part 2. Isoxazoles and Isothiazoles 727
Autur M. S. Silva, Augusto C. Tomé, Teresa M. V. D. Pinho e Melo, and José Elguero

10. Five-Membered Heterocycles: 1,3-Azoles 809
Julia Revuelta, Fabrizio Machetti, and Stefano Cicchi

11. Five-Membered Heterocycles with Two Heteroatoms: O and S Derivatives 925
David J. Wilkins

12. Five-Membered Heterocycles with Three Heteroatoms: Triazoles 989
Larry Yet

13. Oxadiazoles 1047
Giovanni Romeo and Ugo Chiacchio

Volume 3

14. Thiadiazoles 1253
Ugo Chiacchio and Giovanni Romeo

15. Five-Membered Heterocycles with Four Heteroatoms Tetrazoles 1401
Ulhas Bhatt

16. Six-Membered Heterocycles: Pyridines 1431
Concepción González-Bello and Luis Castedo

17. Six-Membered Heterocycles: Quinoline and Isoquinoline 1527
Ramón Alajarín Carolina Burgos

18. Six-Membered Rings with One Oxygen: Pyrylium Ion, Related Systems and Benzo-Derivatives 1631
Javier Santamaría and Carlos Valdés

19. Six-Membered Heterocycles: 1,2-, 1,3-, and 1.4-Diazines and Related Systems 1683
María-Pa Cabal

20. Six-Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems 1777
Cristina Gómez de Oliva, Pilar Goya Laza, and Carmen Ochoa de Ocariz

Volume 4

21. Seven-Membered Heterocycles: Azepines, benzo Derivatives and Related Systems 1865
Juan J. Vaquero, Ana M. Cuadro, and Bernardo Herradón

22. Heterocycles Containing a Ring-Junction Nitrogen 1989
Juan J. Vaquero and Julio Alvarez-Builla

23. Phosphorus Heterocycles 2071
François Mathey

24. The Chemistry of 2-Azetidinones (β-Lactams) 2117
Benito Alcaide, Pedro Almendros, and Amparo Luna

25. The Chemistry of Benzodiazepines 2175
Carlos Valdés and Miguel Bayod

26. Porphyrins: Syntheses and Reactions 2231
Venkataramanarao G. Anand, Alagar Srinivasan, and Tavarekere K. Chandrashekar

27. New Materials Derived From Heterocyclic Systems 2275
Javier Santamaría and José L. García-Álvarez

28. Solid Phase and Combinatorial Chemistry in the Heterocyclic Field 2321
José M. Villalgordo

Index 2381

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Modern Heterocyclic Chemistry, 4 Volumes

Summary

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Modern Heterocyclic Chemistry, 4 Volumes

Summary

Author Biography

Table of Contents

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