Modified Nucleosides in Biochemistry,

Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.

Piet Herdewijn is full professor of Pharmaceutical Sciences at the University of Leuven (Belgium). He holds a Ph.D. from the same institution, having worked as a post-doctoral researcher and assistant professor at the universities of Konstanz (Germany) and Ghent (Belgium) in between. He is a member of the Belgian Academy of Medicine, representing Chemistry, and a founding member of the International Society of Nucleosides, Nucleotides, and Nucleic Acids.
Apart from having close to 500 contributions to scientific journals and books to his credit, he is an editor of the Current Protocols in Nucleic Acid Chemistry, also published by Wiley.

Preface
List of Contributors
Biochemistry and Biophysics
Investigations on Fluorine-Labeled Ribonucleic Acids by 19 F NMR Spectroscopy
Introduction
19 NMR Spectroscopy of Nucleic Acids
Conclusions.References
8-Oxo-7,8-Dihydro-2++Deoxyguanosine: A Major DNA Oxidation Product
Introduction
Formation of 8-Oxo-7,8-Dihydroguanine
Raeactivity of 8-Oxo-7,8-Dihydro-2++-Deoxyguanosine
Formation of 8-Oxo-7,8-Dihydro-2++-Deoxyguanosine in Cellular DNA
Synthesis of 8-OxodGuo and Insertion into Oligonucleotides
Conclusions.References
Modified DNA Bases: Probing Base-Pair Recognition by Polymerases
Introduction
Basic Principles and Methods in Replication
Alternative Hydrogen-Bonding Schemes
Non-Polar Nucleoside Isosteres
Non-Polar Steric Probes
Minor Groove Hydrogen Bonds in Polymerases
Other Non-Polar Bases and Pairs
Replication of Designed Bases in Living Cells
Conclusions and Future Prospects
References
2++-Deoxyribose-Modified Nucleoside Triphosphates and their Recognition by DNA Polymerases
Introduction
Modified Nucleotides as Alternative Building Blocks to Natural Acids
DNA Polymerase Selectivity: 4++-C-Modified Nucleotides
Concluding Remarks
References
Pyrimidine Dimers: UV-Induced DNA Damage
Introduction
Formation of Pyrimidine Dimers
Chemical Synthesis of Oligonucleotides Containing Pyrimidine Dimers
Structure and Mutagenesis of Pyrimidine Dimer-Containing DNA
Repair of Pyrimidine Dimers in Cells

References
Locked Nucleic Acids: Properties, Applications, and Perspectives
Introduction
LNA in Higher-Affinity Hybridization: Designing Sequences
Structural Studies
Analogues of LNA and their Structural Impact
LNA as Potential Therapeutics
LNA-Probes
Concluding Remarks
References
Synthesis and Properties of Oligonucleotides Incorporating Modified Nucleobases Capable of Watson-Crick-Type Base-Pair Formation
Introduction
Natural, Enzyme-Assisted Sophisticated Devices for Maintaining Correct Base Recognition of Canonical Nucleobases
Synthesis and Properties of Oligodeoxynucleotides Incorporating 4-N-Acylated Cytosine Derivatives
Base-Recognition Ability of 4-N-Alkoxycarbonylcytosine Derivatives
Synthesis and Properties of Oligonucleotides Incorporating 4-N-Carbamoylcytosine Derivatives
2-Thiouracil as an Improved Nucleobase in Place of Thymine
Modified Adenine Bases Capable of Recognizing the Thymine Base
Design of Modified Guanine Bases Capable of Recognizing Cytosine
Conclusions
References
The Properties of 4++-Thionucleosides
Introduction
Synthesis of 4++-Thionucleosides
Synthesis of Isothionucleosides
Synthesis of L -Thionucleosides
Synthesis of Thioxonucleosides
Synthesis of Miscellaneous Thionucelosides
Biological Activity of Thionucleosides
Conclusions.References
S-Adenosyl- L -methionine and Related Compounds
Introduction
The Bioche
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Modified Nucleosides in Biochemistry, Biotechnology and Medicine

Summary

Author Biography

Table of Contents

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