The Molecular Basis of Skeletogenesis

Brings together a cross-fertilization of ideas between human molecular genetics, develeopmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis.

Gail Cardew is the editor of The Molecular Basis of Skeletogenesis, published by Wiley.

Jamie Goode is a British author with a PhD in plant biology, and a wine columnist of The Sunday Express. Goode also contributes to wine publications such as Harpers, The World of Fine Wine, Decanter, GrapesTALK and Sommelier Journal.

Symposium on The molecular basis of skeletogenesis, held at the Novartis Foundation, London, 9 --- 11 November 1999

Editors

Gail Cardew

Jamie A. Goode

This symposium is based on a proposal made

Gillian Morriss-Kay

Adam Wilkins

Introduction

1

(5)

Brian Hall

Genetic control of skeletal development

6

(17)

Gerard Karsenty

Discussion

17

(6)

Early steps in limb patterning and chondrogenesis

23

(21)

Sandrine Pizette

Lee Niswander

Discussion

36

(8)

General discussion I

44

(145)

Developmental mechanisms of vertebrate limb evolution

47

(16)

Martin J. Cohn

Discussion

57

(6)

Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3

63

(18)

David M. Ornitz

Discussion

76

(5)

Defects of human skeletogenesis ---- models and mechanisms

81

(21)

Stefan Mundlos

Discussion

91

(11)

Genetic control of the cell proliferation --- differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways

102

(20)

G. M. Morriss-Kay

S. Iseki

D. Johnson

Discussion

116

(6)

Craniosynostosis and related limb anomalies

122

(22)

Andrew O. M. Wilkie

Michael Oldridge

Zequn Tang

Robert E. Maxson Jr

Discussion

133

(11)

The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate

144

(14)

Henry M. Kronenberg

Ung-il Chung

Discussion

152

(6)

Cartilage matrix resorption in skeletogenesis

158

(13)

William Wu

Fackson Mwale

Elena Tchetina

Tadashi Yasuda

A. Robin Poole

Discussion

166

(5)

Retinoid signalling and skeletal development

171

(18)

T. Michael Underhill

Arthur V. Sampaio

Andrea D. Weston

Discussion

185

(4)

General discussion II

189

(83)

Defects in extracellular matrix structural proteins in the osteochondrodysplasias

195

(18)

Daniel H. Cohn

Discussion

210

(3)

Genetic control of bone and joint formation

213

(22)

David M. Kingsley

Discussion

222

(13)

The molecular basis of osteoclast differentiation and activation

235

(16)

Tatsuo Suda

Kanichiro Kobayashi

Eijiro Jimi

Nobuyuki Udagawa

Naoyuki Takahashi

Discussion

247

(4)

Clinical disorders of bone resorption

251

(21)

Graham Russell

Gabrielle Mueller

Claire Shipman

Peter Croucher

Discussion

267

(5)

Final discussion

272

(11)

Index of contributors

283

(2)

Subject Index

285

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The Molecular Basis of Skeletogenesis

Summary

Author Biography

Table of Contents

Supplemental Materials