Molecular Cell Biology
, by Lodish, Harvey; Berk, Arnold; Kaiser, Chris A.; Krieger, Monty; Bretscher, Anthony; Ploegh, Hidde; Amon, Angelika; Scott, Matthew P.
- ISBN: 9781429234139 | 142923413X
- Cover: Hardcover
- Copyright: 5/2/2012
Molecular Cell Biologypresents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of MCBis the use of experiments to engage students in the history of cell biology and the research that has contributed to the field.
| Molecules, Cells, and Evolution | |
| The Molecules of Life | |
| Genomes, Cell Architecture, and Cell Function | |
| Cells into Tissues-Unicellular and Metazoan Organisms Used for Molecular Cell Biology Investigations | |
| Chemical Foundations | |
| Covalent Bonds and Noncovalent Interactions | |
| Chemical Building Blocks of Cells | |
| Chemical Reactions and Equilibrium | |
| Biochemical Energetics | |
| Protein Structure and Function | |
| Hierarchical Structure of Proteins | |
| Protein Folding | |
| Protein Binding and Enzyme Catalysis | |
| Regulating Protein Function | |
| Purifying, Detecting, and Characterizing Proteins | |
| Proteomics | |
| Basic Molecular Genetic Mechanisms | |
| Structure of Nucleic Acids | |
| Transcription of Protein-Coding Genes and Formation of Functional mRNA | |
| The Decoding of mRNA by tRNAs | |
| Stepwise Synthesis of Proteins on Ribosomes | |
| DNA Replication | |
| DNA Repair and Recombination | |
| Viruses: Parasites of the Cellular Genetic System | |
| Molecular Genetic Techniques | |
| Genetic Analysis of Mutations to Identify and Study Genes | |
| DNA Cloning and Characterization | |
| Using Cloned DNA Fragments to Study Gene Expression | |
| Locating and Identifying Human Disease Genes | |
| Inactivating the Function of Specific Genes in Eukaryotes | |
| Genes, Genomics, and Chromosomes | |
| Eukaryotic Gene Structure | |
| Chromosomal Organization of Genes and Noncoding DNA | |
| Transposable (Mobile) DNA Elements | |
| Organelle DNAs | |
| Genomics: Genome-wide Analysis of Gene Structure and Expression | |
| Structural Organization of Eukaryotic Chromosomes | |
| Morphology and Functional Elements of Eukaryotic Chromosomes | |
| Transcriptional Control of Gene Expression | |
| Overview of Eukaryotic Gene Control | |
| RNA Polymerase II and the General Transcription Factors Required for Initiation | |
| Regulatory Sequences in Protein-Coding Genes and the Proteins Through Which They Function | |
| Molecular Mechanisms of Transcription Repression and Activation | |
| Regulation of Transcription-Factor Activity | |
| Epigenetic Regulation of Transcription | |
| Other Eukaryotic Transcription Systems | |
| Post-Transcriptional Gene Control | |
| Processing of Eukaryotic Pre-mRNA | |
| Regulation of Pre-mRNA Processing | |
| Transport of mRNA Across the Nuclear Envelope | |
| Cytoplasmic Mechanisms of Post-transcriptional Control | |
| Processing of rRNA and tRNA | |
| Culturing, Visualizing, and Perturbing Cells | |
| Growing Cells in Culture | |
| Light Microscopy: Exploring Cell Structure and Visualizing Proteins within Cells | |
| Electron Microscopy: High-Resolution Imaging | |
| Isolation and Characterization of Cell Organelles | |
| Perturbing Specific Cell Functions | |
| Biomembrane Structure | |
| The Phospholipid Bilayer: Composition and Structural Organization | |
| Membrane Proteins: Structure and Basic Functions | |
| Phospholipids, Sphingolipids, and Cholesterol: Synthesis and Intracellular Movements | |
| Transmembrane Transport of Ions and Small Molecules | |
| Overview of Transmembrane Transport | |
| Facilitated Transport of Glucose and Water | |
| ATP-Powered Pumps and the Intracellular Ionic Environment | |
| Nongated Ion Channels and the Resting Membrane Potential | |
| Cotransport by Symporters and Antiporters | |
| Transcellular Transport | |
| Cellular Energetics | |
| First Step of Harvesting Energy from Glucose: Glycolysis | |
| Mitochondria and the Citric Acid Cycle | |
| The Electron Transport Chain and Generation of the Proton-Motive Force | |
| Harnessing the Proton-Motive Force to Synthesize ATP | |
| Photosynthesis and Light-Absorbing Pigments | |
| Molecular Analysis of Photosystems | |
| CO2 Metabolism During Photosynthesis | |
| Moving Proteins Into Membranes and Organelles | |
| Insertion of Membrane Proteins into the ER | |
| Protein Modifications, Folding, and Quality Control in the ER | |
| Targeting of Proteins to Mitochondria and Chloroplasts | |
| Targeting of Peroxisomal Proteins | |
| Transport into and out of the Nucleus | |
| Vesicular Traffic, Secretion, and Endocytosis | |
| Techniques for Studying the Secretory Pathway | |
| Molecular Mechanisms of Vesicular Budding and Fusion | |
| Early Stages of the Secretory Pathway | |
| Later Stages of the Secretory Pathway | |
| Receptor-Mediated Endocytosis | |
| Directing Membrane Proteins and Cytosolic Materials to the Lysosome | |
| Signal Transduction and G Protein-Coupled Receptors | |
| Signal Transduction: From Extracellular Signal to Cellular Response | |
| Studying Cell-Surface Receptors and Signal Transduction Proteins | |
| G Protein-Coupled Receptors: Structure and Mechanism | |
| G Protein-Coupled Receptors That Regulate Ion Channels | |
| G Protein-Coupled Receptors That Activate or Inhibit Adenylyl Cyclase | |
| G Protein-Coupled Receptors That Trigger Elevations in Cytosolic Ca2+ | |
| Signaling Pathways That Control Gene Expression | |
| Receptors That Activate Protein Tyrosine Kinases | |
| The Ras/MAP Kinase Pathway | |
| Phosphoinositide Signaling Pathways | |
| Receptor Serine Kinases That Activate Smads | |
| Signaling Pathways Controlled by Ubiquitination: Wnt, Hedgehog, and NF-kB | |
| Signaling Pathways Controlled by Protein Cleavage: Notch/Delta, SREBP | |
| Integration of Cellular Responses to Multiple Signaling Pathways | |
| Cell Organization and Movement I: Microfilaments | |
| Microfilaments and Actin Structures | |
| Dynamics of Actin Filaments | |
| Mechanisms of Actin Filament Assembly | |
| Organization of Actin-Based Cellular Structures | |
| Myosins: Actin-Based Motor Proteins | |
| Myosin-Powered Movements | |
| Cell Migration: Mechanism, Signaling and Chemotaxis | |
| Cell Organization and Movement II: Microtubules and Intermediate Filaments | |
| Microtubule Structure and Organization | |
| Microtubule Dynamics | |
| Regulation of Microtubule Structure and Dynamics | |
| Kinesins and Dyneins: Microtubule-Based Motor Proteins | |
| Cilia and Flagella: Microtubule-Based Surface Structures | |
| Mitosis | |
| Intermediate Filaments | |
| Coordination and Cooperation between Cytoskeletal Elements | |
| The Eukaryotic Cell Cycle | |
| Overview of the Cell Cycle and its Control | |
| Model Organisms and Methods to Study the Cell Cycle | |
| Regulation of CDK Activity | |
| Commitment to the Cell Cycle and DNA Replication | |
| Entry into Mitosis | |
| Completion of Mitosis: Chromosome Segregation and Exit from Mitosis | |
| Surveillance Mechanisms in Cell Cycle Regulation | |
| Meiosis: A Special Type of Cell Division | |
| Integrating Cells Into Tissues | |
| Cell-Cell and Cell-Matrix Adhesion: An Overview | |
| Cell-Cell and Cell-ECM Junctions and Their Adhesion Molecules | |
| The Extracellular Matrix I: The Basal Lamina | |
| The Extracellular Matrix II: Connective Tissue | |
| Adhesive Interactions in Motile and Nonmotile Cells | |
| Plant Tissues | |
| Stem Cells, Cell Asymmetry, and Cell Death | |
| Early Metazoan Development and Embryonic Stem Cells | |
| Stem Cells and Niches in Multicellular Organisms | |
| Regulation of Asymmetric Cell Division | |
| Cell Death and Its Regulation | |
| Nerve Cells | |
| Neurons and Glia: Building Blocks of the Nervous System | |
| Voltage-Gated Ion Channels and the Propagation of Action Potentials | |
| Communication at Synapses | |
| Sensing the Environment: Touch, Pain, Taste, and Smell | |
| Immunology | |
| Overview of Host Defenses | |
| Immunoglobulins: Structure and Function | |
| Generation of Antibody Diversity and B-Cell Development | |
| The MHC and Antigen Presentation | |
| T Cells, T-Cell Receptors, and T-Cell Development | |
| Collaboration of Immune-System Cells in the Adaptive Response | |
| Cancer | |
| Tumor Cells and the Onset of Cancer | |
| The Genetic Basis of Cancer | |
| Cancer and the Misregulation of Growth Regulatory Pathways | |
| Cancer and Mutation of Cell Division and Checkpoint Regulators | |
| Carcinogens and Caretaker Genes in Cancer | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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