Mouse Genetics Concepts and Applications

The mouse genome contains nearly all of the human genes, making it anideal mammalian system for genetic analysis. Mouse Genetics: Concepts andApplications offers for the first time in a single resource a practical guide tomaintaining a breeding mouse colony and to performing genetic studies with themost up-to-date molecular probe methods available. Topics range from geneticvariations between different mouse types to reproduction to genetic marker tomouse suppliers. As investigators around the world are rediscovering both theheuristic and practical value of the mouse genome, the demand for a succinct,well-written introduction to the subject has never been greater. Mouse Geneticswill be welcomed by students and researchers studying genetics and molecularbiology.

An Introduction to Mice
Of Mice, Men, and a Woman
The Origin of Mice in Genetic Research
The New Biology and the Mouse Model
Town Mouse, Country Mouse
What are Mice?
Where Do Mice Come From?
The Mus Species Group and the House Mouse
Lifestyles and Adaptability of Wild House Mice
Laboratory Mice
Sources of Laboratory Mice
Mouse Crosses and Standard Strains
Coisogenics, Congenics, and Other Specialized Strains
Standardized Nomenclature
Strategies for Record-Keeping
Reproduction and Breeding
Reproductive Performance: Comparison of Inbred Strains
Germ Cell Differentiation and Sexual Maturation
Mating and Pregnancy
The Postnatal Period
Assisted Reproduction for the Infertile Cross
The Mouse Genome
Quantifying the Genome
Chromosomes
Genome Evolution and Gene Families
Repetitive "Non-Functional" DNA Families
Genomic Imprinting
Mutagenesis and Transgenesis
Classical Mutagenesis
Embryo Manipulation
Transgenic Mice Formed by Nuclear Injection
Targeted Mutagenesis and Gene Replacement
Further Uses of Transgenic Technologies
Mapping in the Mouse: An Overview
Genetic Maps Come in Various Forms
Mendel's Genetics, Linkage, and the Mouse
General Strategies for Mapping Mouse Loci
The Final Chapter of Genetics
Genetic Markers
Genotypic and Phenotypic Variation
Restriction Fragment Length Polymorphisms (RFLPs
Polymorphisms Detected by PCR
Region-Specific Panels of DNA Markers
Classical Linkage Analysis and Mapping Panels
Demonstration of Linkage in the Mouse
Recombinant Inbred Strains
Interspecific Mapping Panels
Starting From Scratch With a New Mapping Project
Quantitative Traits and Polygenic Analysis
Non-Breeding Mapping Strategies
Linkage Maps Without Breeding
Chromosomal Mapping Tools
Physical Maps and Positional Cloning
The Human Genome Project and the Ultimate Map
Suppliers of Mice
Computational Tools and Electronic Databases
Source Materials for Further Reading
Statistics
Glossary of Terms
Table of Contents provided by Publisher. All Rights Reserved.

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Mouse Genetics Concepts and Applications

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