Myelin

Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.

Myelin Structure and Components
Organization, Phylogenetic Variations, and Dynamic Transitions of Myelin	p. 3
Cell Biology of Myelination
The Oligodendrocyte Lineage during Myelination and Remyelination	p. 81
The Cell of Schwann: An Update	p. 123
Axonal Contact as a Determinant of Oligodendrocyte and Schwann Cell Function	p. 173
Myelin Lipids
Interactions of Lipids with Proteins of Myelin and its Associated Cytoskeleton	p. 197
Synthesis and Turnover of Myelin Phospholipids and Cholesterol	p. 213
Structure and Molecular Biology of the Major Myelin Proteins
Structure and Acylation of Proteolipid Protein	p. 237
The Myelin Proteolipid Protein Gene and its Expression	p. 257
Structure and Molecular Interactions of Myelin Basic Protein and its Antigenic Peptides	p. 277
Molecular Genetics of Myelin Basic Protein	p. 367
Myelin Basic Protein Isoforms: Structural and Evolutionary Implications of Alternative Exon Splicing	p. 387
Myelin-Associated Glycoprotein: Structure-Function Relationships and Involvement in Neurological Diseases	p. 413
2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Molecular Characterization and Possible Functional Significance	p. 449
Structure and Molecular Biology of PO Protein	p. 481
Myelin P2, a Neuritogenic Member of the Family of Cytoplasmic Lipid-Binding Proteins	p. 509
Myelin-Associated Enzymes, Receptors, and Mitogens
Enzymes and Receptors of Myelin	p. 531
Calcium-Activated Neutral Proteinase in Myelin: its Role and Function	p. 571
Degradation of Myelin Proteins by Proteinases	p. 599
A Mitogenic Factor Derived from the Myelin Membrane	p. 633
Myelin Mutants
Phenotypic Expression of X-Linked Genetic Defects Affecting Myelination	p. 653
Amino Acid Substitutions in Proteolipid Protein that Cause Dysmyelination	p. 677
Pelizaeus-Merzbacher Disease: X-Linked Proteolipid Protein Deficiency in the Human Central Nervous System	p. 703
Shiverer and Allelic Mutant MLD Mice	p. 723
The Twitcher Mouse: a Model of Human Globoid Cell Leukodystrophy (Krabbe Disease)	p. 745
Chimeras in the Study of Disorders of Myelination	p. 761
Transgenic Mice in Myelin in Research	p. 773
Demyelination
Strain and Species Differences of Encephalitogenic Determinants of Myelin Basic Protein and Proteolipid Apoprotein	p. 783
The Complement System in Demyelination	p. 801
Human T-Cell Recognition of Myelin Basic Protein Peptides	p. 833
Chronic Experimental Allergic Encephalomyelitis as a Model of Multiple Sclerosis	p. 849
Virus-Induced Demyelination	p. 893
Index	p. 935
Table of Contents provided by Blackwell. All Rights Reserved.

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