NECROTIZING ENTEROCOLITIS

SUNY Health Science Center, Brooklyn, NY. Comprises a comprehensive bioscience and biomedical report database on Necrotizing Enterocolitis. Provides prospective on NEC and recommends a change for the paradigm for the treatment of NEC. For researchers.

Colin A.I. Bethel, M.D. is Assistant Professor of Surgery UMDNJ Newark, New Jersey, U.S.A. Christopher Breuer, M.D. is Instructor in Pediatric Surgery Brown University, Hasbro Children's Hospital, Providence, Rhode Island. Benjamin Z. Cooper, M.D. is Instructor in Surgery SUNY-HSCB, Brooklyn, New York. Carlotta Hample, M.D. is Assistant Professor of Pediatrics SUNY-HSCB, Brooklyn, New York. Katrine Hasen, M.D. is Assistant Professor of Pathology Brown University, Hasbro Children's Hospital, Providence, Rhode Island. Marc Lessin, M.D. is Assistant Professor of Surgery, Tufts University The Floating Hospital, Boston, Massachusetts. Steven Piecuch, M.D. is Clinical Assistant Professor and Attending Neonatologist, SUNY-HSCB, Department of Pediatrics Brooklyn, New York. John N. Schullinger, M.D., F.A.C.S. is Emeritus Professor of Surgery, Babies Hospital of New York, Columbia-Presbyterian Medical Center, New York, New York. Richard J. Scriven, M.D. is Instructor in Surgery, SUNY-HSCB, Brooklyn, New York. E. Christine Wallace, M.B. is Assistant Professor of Radiology, Tufts University, The Floating Hospital, Boston, Massachusetts.

The History of Necrotizing Enterocolitis Investigation	p. 1
Pathogenesis	p. 2
Management	p. 5
Summary	p. 6
The Bacteriology of Necrotizing Enterocolitis	p. 9
Theories of Pathogenesis of NEC as Related to Bacteriology	p. 9
Bacteriology of NEC	p. 10
Controlling the Infectious Process: A Means of Prevention and Treatment of NEC	p. 12
Conclusion	p. 13
The Immunology of Necrotizing Enterocolitis	p. 15
Gastrointestinal Mucosal Immune System	p. 15
Defects in Systemic and Mucosal Immunity in the Newborn	p. 17
Nonimmune Epithelial Barrier Functions	p. 18
The Protective Effect of Breast Feeding	p. 19
The Role of Systemic and Enteral Immunoglobulins	p. 21
Beneficial Effects of Steroids in Reducing Necrotizing Enterocolitis	p. 21
Bacterial Translocation in Necrotizing Enterocolitis and the Protective Effect of Enteral Antibiotics	p. 22
Cytokines and Inflammatory Mediators	p. 23
Summary	p. 25
The Radiology of Necrotizing Enterocolitis	p. 31
Techniques of Evaluation	p. 31
Indications	p. 31
Radiographic Projections	p. 31
Radiographic Features	p. 34
Ultrasound	p. 45
Complications	p. 46
Conclusion	p. 53
The Medical and ICU Management of Necrotizing Enterocolitis	p. 55
Epidemiology	p. 55
Pathophysiology	p. 55
Diagnosis	p. 57
Classification	p. 57
Treatment	p. 57
Late Complications	p. 60
Future Directions	p. 60
The Surgery of Necrotizing Enterocolitis	p. 63
Preparation of the Infant for Surgery	p. 63
General Operative Approach	p. 63
Specific Considerations: Management of Focal Necrosis	p. 64
Specific Considerations: Management of NEC "Totalis"	p. 66
Specific Considerations: Management of the Very Premature Infant ([ 1000 g)	p. 67
Treatment of Post-NEC Strictures	p. 67
The Pathology of Necrotizing Enterocolitis	p. 69
Pathology	p. 69
Infection	p. 73
Inflammatory Mediators	p. 74
The Nutritional Concerns in Necrotizing Enterocolitis	p. 77
Physiology of Short Bowel Syndrome	p. 77
Adaptation	p. 78
Nutrition	p. 79
Clinical Management	p. 80
Complications	p. 81
Intestinal Transplant	p. 82
The Use of Small Bowel Transplantation in Necrotizing Enterocolitis	p. 85
Necrotizing Enterocolitis	p. 85
Short Bowel Syndrome	p. 86
Intestinal Transplantation	p. 87
Conclusion	p. 88
Afterword	p. 91
Index	p. 93
Table of Contents provided by Syndetics. All Rights Reserved.

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NECROTIZING ENTEROCOLITIS

Summary

Author Biography

Table of Contents

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