Neuroprotective Agents : Fourth International Conference

, by Trembly, Bruce; Slikker, William

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ISBN: 9781573312226 | 1573312223
Cover: Hardcover
Copyright: 12/1/1999

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Preface by The Editors

Part I. Overview of Neuroprotection

U.S. Food and Drug Administration: Future of New Product Strategies and FDA Priorities.

(1)

B.A. Schwetz

Neuroprotection against Cerebral Ischemia: A Review of Animal Studies and Correlation with Human Trial Results.

(5)

S. Jonas

V. Ayigari

D. Viera

P. Waterman

Questions and Answers

(3)

Part II. Clinical Orientation

The Pivotal Role of Iron in NF-kB Activation and Nigrostriatal Dopaminergic Neurodegeneration: Prospects for Neuroprotection in Parkinson's Disease with Iron Chelators.

(19)

M.B.H. Youdim

E. Grunblatt

S. Mandel

Hypothermia-Induced Ischemic Tolerance.

(16)

Shinsaku Nishio

Zong-Fu Chen

Masatoshi Yunoki

Tomikatsu Toyoda

Matthew Anzivino

Kevin S. Lee

A Double-Blind, Placebo-Controlled Study of the Safety, Tolerability and Pharmacokinetics of CP-101,606 in Patients with a Mild or Moderate Traumatic Brain Injury.

(9)

Randall E. Merchant

M. Ross Bullock

Cynthia A. Carmack

Ajit K. Shah

Keith D. Wilner

Grant Ko

Stephen A. Williams

An Open-Label Study of CP-101,606 in Subjects with a Severe Traumatic Head Injury or Spontaneous Intracerebral Hemorrhage.

(8)

M. Ross Bullock

Randall E. Merchant

Cynthia A. Carmack

Egon Doppenberg

Ajit K. Shah

Keith D. Wilner

Grant Ko

Stephen A. Williams

Neuroprotective ``Agents'' in Surgery: Secret ``Agent'' Man, or Common ``Agent'' Machine?

(20)

Russell J. Andrews

Questions and Answers

(6)

Part III. Endogenous Neuroprotectants

Brain Adenosine Receptors as Targets for Therapeutic Intervention in Neurodegenerative Diseases.

(14)

Maria P. Abbracchio

Flaminio Cattabeni

Stimulation of Adenosine A3 Receptors in Cerebral Ischemia: Neuronal Death, Recovery, or Both?

(14)

Dag K.J.E. Von Lubitz

Wen Ye

Jennifer McClellan

Rick C.-S. Lin

Excitotoxicity, Oxidative Stress, and the Neuroprotective Potential of Melatonin.

107

(12)

S.D. Skaper

M. Floreani

M. Ceccon

L. Facci

P. Giusti

Neuroprotective Role of Melatonin in Methamphetamine- and 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurotoxicity.

119

(1)

Syed F. Ali

Julio L. Martin

M. Dean Black

Yossef Itzhak

Neuroprotective and Cognitive Enhancing Effects of Novel Small Peptides.

120

(1)

A.I. Faden

G. Fox

L. Fan

S. Knoblach

G.L. Araldi

A.P. Kozikowski

Estrogens: Neuroprotective or Neurotoxic?

121

(12)

Andrew C. Scallet

Role of Glycemia in Acute Spinal Cord Injury: Data from a Rat Experimental Model and Clinical Experience.

133

(22)

Francesco Sala

Gaetano Menna

Albino Bricolo

Wise Young

N-Acetylserotonin, Melatonin and Their Derivatives Improve Cognition and Protect against β-Amyloid-Induced Neurotoxicity.

155

(12)

S. Bachurin

G. Oxenkrug

N. Lermontova

A. Afanasiev

B. Beznosko

G. Vankin

E. Shevtzova

T. Mukhina

T. Serkova

Neuroprotective Action of Bilirubin against Oxidative Stress in Primary Hippocampal Cultures.

167

(6)

Sylvain Dore

Solomon H. Snyder

Protective Effect of l-Carnitine in the Neurotoxicity Induced by the Mitochondrial Inhibitor 3-Nitropropionic Acid (3-NPA).

173

(10)

Zbigniew Binienda

John R. Johnson

Alexander A. Tyler-Hashemi

Robert L. Rountree

Philip P. Sapienza

Syed F. Ali

Chung S. Kim

Questions and Answers

179

(4)

Part IV. Mechanisms: Neurodegeneration, Injury, Toxicity

Primary Cultures of Rat Cerebellar Granule Cells as a Model to Study Neuronal 5-Lipoxygenase and FLAP Gene Expression.

183

(8)

Hari Manev

Tolga Uz

Intraneuronal Ion Distribution during Experimental Oxygen/Glucose Deprivation: Routes of Ion Flux as Targets of Neuroprotective Strategies.

191

(13)

Richard M. LoPachin

Matrix Remodeling after Stroke: De Novo Expression of Matrix Proteins and Integrin Receptors.

204

(19)

Julie A. Ellison

Frank C. Barone

Giora Z. Feuerstein

Metallothioneins Attenuate Methylmercury-Induced Neurotoxicity in Cultured Astrocytes and Astrocytoma Cells.

223

(4)

Chang Ping Yao

Jeffrey W. Allen

Michael Aschner

Implication of Poly (ADP-Ribose) Polymerase (PARP) in Neurodegeneration and Brian Energy Metabolism: Decreases in Mouse Brain NAD+ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide.

227

(13)

Cristina Cosi

Marc Marien

Neuroprotection against Ischemia by Metabolic Inhibition Revisited: A Comparison of Hypothermia, a Pharmacologic Cocktail and Magnesium Plus Mexiletine.

240

(21)

Kenneth I. Maynard

Alfredo Quinones-Hinojosa

Junaid Y. Malek

Questions and Answers

255

(6)

Part V. Calpain and Neuronal Degeneration

Calpetin and Methylprednisolone Inhibit Apoptosis in Rat Spinal Cord Injury.

261

(9)

Swapan K. Ray

Gloria G. Wilford

Denise C. Matzelle

Edward L. Hogan

Naren L. Banik

Calpastatin Is Upregulated and Acts as a Suicide Substrate to Calpains in Neonatal Rat Hypoxia-Ischemia.

270

(3)

Klas Blomgren

Questions and Answers

272

(1)

Part VI. Glutamate Excitotoxicity: Does It Really Exist?

High Extracellular Glutamate and Neuronal Death in Neurological Disorders: Cause Contribution or Consequence?

273

(14)

Tihomir P. Obrenovitch

Evidence Disputing the Importance of Excitotoxicity in Hippocampal Neuron Death after Experimental Traumatic Brain Injury.

287

(14)

W. Shawn Carbonell

M. Sean Grady

Questions and Answers

299

(2)

Part VII. Neurologic Insults: Mechanisms and Strategies

Neuroprotective Properties of Nitric Oxide.

301

(11)

Chuang C. Chiueh

Neuroprotective Strategies for HIV-1-Associated Neurologic Disease.

312

(2)

Harris A. Gelbard

Changes in mRNA Levels for Heat-Shock/Stress Proteins (Hsp) and a Secretory Vesicle Associated Cysteine-String Protein (Csp1) after Amphetamine (AMPH) Exposure.

314

(16)

John F. Bowyer

David L. Davies

Benzamide, a Poly(ADP-Ribose) Polymerase Inhibitor, Is Neuroprotective against Soman-Induced Seizure-Related Brain Damage.

330

(6)

H.L. Meier

G.P.H. Ballough

J.S. Forster

M.G. Filbert

Central Noradrenergic Neurotoxicity of DSP4 in Mice: Studies on the Neuroprotective Potential of the Poly(ADP-Ribose) Polymerase Inhibitor, Benzamide.

336

(4)

Marc Marien

Cristina Cosi

The Antioxidative Effect of Carboxyfullerenes (C3/D3) on Iron-Induced Oxidative Injury in CNS.

340

(15)

Anya M.Y. Lin

T.-Y. Luh

C.K. Chou

L.T. Ho

Questions and Answers

352

(3)

Part VIII. Growth Factors

Neuregulin Signaling in Brain Injury and in Animal Models of Ischemia.

355

(1)

Mark A. Marchionni

Marc A. Soriano

Ian Murdoch

Elizebeth McCracken

Deborah Dewar

James McCulloch

Protective and Rescuing Abilities of IGF-I and Some Putative Free Radical Scavengers against β-Amyloid-Inducing Toxicity in Neurons.

356

(10)

Sylvain Dore

Stephane Bastianetto

Satyabrata Kar

Remi Quirion

Questions and Answers

365

(1)

Part IX. Spinal Cord Injury: Importance of Inflammatory Response

The Unique Histopathological Responses of the Injured Spinal Cord: Implications for Neuroprotective Therapy.

366

(19)

Lloyd Guth

Ziyin Zhang

Oswald Steward

Part X. Glutamate Receptor Agents

Ion Channel Modulation as the Basis for Neuroprotective Action of MS-153.

385

(15)

Hiroaki Uenishi

Chao-Sheng Huang

Jin-Ho Song

William Marszalec

Toshio Narahashi

Blockade of NAALADase: A Novel Neuroprotective Strategy Based on Limiting Glutamate and Elevating NAAG.

400

(6)

James J. Vornov

Krystyna Wozniak

May Lu

Paul Jackson

Takashi Tsukamoto

Eric Wang

Barbara Slusher

The Low-Affinity, Use-Dependent NMDA Receptor Antagonist AR-R 15896AR: An Update of Progress in Stroke.

406

(15)

Gene C. Palmer

Edward F. Cregan

Paul Bialobok

Simon G. Sydserff

Thomas J. Hudzik

Dennis J. McCarthy

Intracellular Survival Pathways against Glutamate Receptor Agonist Excitotoxicity in Cultured Neurons: Intracellular Calcium Responses.

421

(17)

Ann M. Marini

Yuji Ueda

Carl H. June

Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors.

438

(12)

A.E. Kingston

M.J. O'Neill

A. Bond

V. Bruno

G. Battaglia

F. Nicoletti

J.R. Harris

B.P. Clark

J.A. Monn

D. Lodge

D.D. Schoepp

NPS 1506, A Novel NMDA Receptor Antagonist and Neuroprotectant: Review of Preclinical and Clinical Studies.

450

(12)

Alan L. Mueller

Linda D. Artman

Manuel F. Balandrin

Ellen Brady

Yongwei (Eric) Chien

Eric G. Delmar

Karen George

Allison Kierstead

Thomas B. Marriott

Scott T. Moe

Michael K. Newman

Joanna L. Raszkiewicz

Elizabeth L. Sanguinetti

Bradford C. Van Wagenen

David Wells

Questions and Answers

458

(4)

Part XI. Antioxidants, Cytokines, Unique Animal Model

Peroxynitrite Scavengers for the Acute Treatment of Traumatic Brain Injury.

462

(7)

Edward D. Hall

Nancy C. Kupina

John S. Althaus

Regional Cytokine, Cytokine Receptor and Neuropeptide mRNA Changes Associated with Behavioral and Neuroanatomical Abnormalities in Persistent, Noninflammatory Virus Infection of Neonatal Rats.

469

(1)

Carlos R. Plata-Salaman

Sergey E. Ilyin

Dave Gayle

Anna Romanovitch

Kathryn M. Carbone

Development of a Nonhuman Primate Model for Studying the Consequences of Long-Term Neuroprotectant Administration on Complex Brain Functions in Developing Animals.

470

(1)

Merle G. Paule

E. Jon Popke

Edwin Pearson

Tim Hammond

Melatonin as a Pharmacological Agent against Neuronal Loss in Experimental Models of Huntington's Disease, Alzheimer's Disease and Parkinsonism.

471

(18)

Russel J. Reiter

Javier Cabrera

Rosa M. Sainz

Juan Carlos Mayo

Lucien C. Manchester

Dun-Xian Tan

Questions and Answers

486

(3)

Part XII. Drugs of Abuse

The Regulation of Cerebral Blood Flow during Intravenous Cocaine Administration in Cocaine Abusers.

489

(6)

Ronald I. Herning

Warren Better

Richard Nelson

David Gorelick

Jean L. Cadet

Time Course of Brain Temperature and Caudate/Putamen Microdialysate Levels of Amphetamine and Dopamine in Rats after Multiple Doses of d-Amphetamine.

495

(10)

Peter Clausing

John F. Bowyer

Neuroprotective Effects of HU-211 on Brain Damage Resulting from Soman-Induced Seizures.

505

(10)

Margaret G. Filbert

Jeffry S. Forster

C. Dahlem Smith

Gerald P.H. Ballough

Abuse Liability Assessment of Neuroprotectants.

515

(14)

Michael Klein

Silvia Calderon

BeLinda Hayes

Questions and Answers

526

(3)

Part XIII. Conference Summary

The Future of Neuroprotection.

529

(6)

W. Slikker

M. Youdim

Gene C. Palmer

E. Hall

C. Williams

B. Trembly

Index of Contributors

535

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Neuroprotective Agents : Fourth International Conference

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