Neuroscientific Basis of Dementia

This volume presents both an overall and a detailed overview of the current worldwide knowledge about the neuroscientific basis of dementia.
Leading authorities in their fields provide a far-reaching synthesis of all topics in dementia research, including pathogenesis of dementia, neuroimaging of the earliest alterations, potential biological and genetic markers for Alzheimer's Disease and new therapeutic strategies. Each chapter discusses clinical implications and areas of controversy, highlights the wide range of current and future therapeutic possibilities and indicates promising directions for further research.
The book will be of high value not only to scientists and graduate students in medical, pharmacological and biological research, but also to physicians and researchers in the biotechnological and pharmaceutical industries.

List of contributors
Preface
A tale of protein kinase C and membrane lipid signaling	p. 3
Complement, neuroinflammation and neuronal degeneration in Alzheimer disease	p. 15
Neurobiological mechanisms by which emotional arousal influences long-term memory formation	p. 23
Amygdalar damage and memory impairment in Alzheimer's disease	p. 35
Neural substrate for spatial memory in the monkey hippocampus	p. 43
Involvement of CaM kinase II and mitogen-activated protein kinase in hippocampal long-term potentiation	p. 49
Transgenic mice overexpressing the shortest human tau isoform develop a progressive tauopathy	p. 61
Tau and neurodegenerative disease: genetics and pathogenetic mechanisms	p. 71
The mutations altering splicing of tau exon 10 in japanese frontotemporal dementia	p. 81
Amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan (Kii ALS/PDC) may be a familial tauopathy, Epidemiological trends, clinical features, neuropathology and molecular genetics	p. 85
Senile dementia of the neurofibrillary tangle type (SD-NFT): a clinical, neuropathological and molecular genetic study	p. 95
The dual role of tau in cell polarisation and organelle trafficking	p. 101
Rearrangement of microtubule networks by tau bearing missense mutations	p. 113
Possible role of tau phosphorylation on ER membrane in Alzheimer patholoy	p. 121
Pathogenesis of dementia: updating the role of synuclein pathology in sporadic and hereditary Alzheimer's disease	p. 131
[alpha]-Synuclein/NACP and neurodegeneration	p. 137
[alpha]-Synuclein fibrillogenesis as target for drug development	p. 143
Genetics of early-onset Alzheimer disease	p. 153
Lessons from presenilin domain analysis: endoproteolytic processing and enhanced A[beta]42 production mediated by FAD-linked variants	p. 167
Amyloid and presenilins in the pathobiology of Alzheimer's disease	p. 177
Role of presenilin in APP processing and A[beta] production	p. 183
Impairment of response to ER stress in presenilin 1 mutant	p. 193
Mechanism of neuron death in Alzheimer's disease	p. 201
Notch3 gene in CADASIL syndrome: mutation frequencies in Japanese and its expression and processing	p. 209
Etiological roles of A[beta] and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease	p. 217
Amyloid [beta]-protein granules in glial cells in Alzheimer's disease brain	p. 225
Amyloid [beta] induces phosphorylation and translocation of MARCKS through tyrosine kinase-activated PKC-[delta] signaling pathway in microglia	p. 229
Amyloid [beta]-protein accumulation in the human brain during aging	p. 233
Molecular mechanisms underlying initiation of amyloid fibril formation	p. 241
Catabolism of amyloid-[beta] peptide in brain parenchyma	p. 249
Lessons in familial Alzheimer's disease	p. 259
Biological markers for differential diagnosis of Alzheimer's disease and related disorders	p. 267
Dietary factors and the risk of Alzheimer's disease: a low fish consumption and a relative deficiency of [omega]-3 polyunsaturated fatty acids	p. 275
Risk factors for dementia	p. 279
New therapeutic approaches to Alzheimer's disease	p. 287
Subject index	p. 295
Table of Contents provided by Blackwell. All Rights Reserved.

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Neuroscientific Basis of Dementia

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