New Therapeutic Targets In Rheumatoid

The volume focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter discusses the biological rationale in great detail, including in vitro work and work in animal models, and where appropriate, results form clinical trials.The book is written by an international authorship of experts in this field. It is of interest to rheumatologists, immunologists, internists, investigators in immunology and rheumatology, the pharmaceutical industry.

List of contributors	p. vii
Preface	p. xi
B cell targets in rheumatoid arthritis	p. 1
Co-stimulatory pathways in the therapy of rheumatoid arthritis	p. 27
Immunobiology of IL-6- Tocilizumab (humanized anti-IL-6 receptor antibody) for the treatment of rheumatoid arthritis	p. 45
Role of IL-1 in erosive arthritis, lessons from animal models	p. 59
Interleukin-15	p. 75
IL-17 and Th17 cells, key players in arthritis	p. 89
Role of IL-18 in inflammatory diseases	p. 103
Chemokines and chemokine receptors	p. 129
Signaling pathways in rheumatoid arthritis	p. 155
Targeting oncostatin M in the treatment of rheumatoid arthritis	p. 181
Targeting the epigenetic modifications of synovial cells	p. 193
Perspectives in targeted therapy	p. 207
Index	p. 221
Table of Contents provided by Ingram. All Rights Reserved.

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New Therapeutic Targets In Rheumatoid Arthritis

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