Nutritional Pathology: Pathobiochemistry of

It has become increasingly apparent that manipulations in nutrition -- exogenous or endogenous -- may be involved in the pathogenesis of many disease states ranging from metabolic disorders, such as diabetes and obesity, to the prime killer diseases, such as cancer and cardiovascular disease. This timely, authoritative reference examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. Approaching the effects of nutrition from a molecular biology perspective, Nutritional Pathology investigates specific pathological aspects of diet and dietary imbalances, including effects of malnutrition on pancreatic disease, cardiovascular disease, and the central nervous system ... the role of nutrition in drug metabolism and toxicity ... deficiencies in choline, tryptophan, and dietary fibers ... consequences of drug-induced malnutrition ... and much more. Well illustrated and extensively referenced for easy access to the broad expansion of research in this area, Nutritional Pathology will serve as an important resource for all researchers involved in this advancing science, including pathologists, nutritionists, biochemists, cell biologists, toxicologists, epidemiologists, pharmacologists, and oncologists. Moreover, this volume is an essential information source for graduate students in pathology, nutrition, and biochemistry. Book jacket.

Preface	p. v
Contributors	p. vii
Tryptophan: Unique Action by an Essential Amino Acid	p. 1
Introduction	p. 1
Historical Data and Findings in Deficiencies	p. 1
Occurrence in Nature and in Mammals	p. 3
Chemical Pathways	p. 4
Effect on the Central Nervous System	p. 6
Effect on the Liver	p. 9
Effect on the Livers of Rats Treated with Hepatotoxic Agents	p. 27
Effect on Other Organs	p. 29
Tryptophan and Hormones	p. 30
Tryptophan and Cancer	p. 31
Tryptophan and Pregnancy	p. 34
Tryptophan and Aging	p. 36
Tryptophan and Hepatic Coma	p. 36
Other Essential Amino Acids and Their Possible Unique Actions	p. 39
Potential Importance of Tryptophan and Its Unique Actions	p. 40
References	p. 41
Effects of Nutrition on Transcriptional and Translational Controls of Protein Synthesis in Liver	p. 63
Introduction	p. 63
Mechanisms that Control Hepatic Protein Synthesis	p. 64
Influence of Nutritional Components on Hepatic Protein Synthesis	p. 68
Conclusions	p. 99
References	p. 99
Nutritionally Induced Pancreatic Disease	p. 115
Introduction	p. 115
Exocrine Pancreas	p. 116
Endocrine Pancreas	p. 123
Conclusion	p. 123
References	p. 124
Nutrition and Cardiovascular Disease	p. 127
Introduction	p. 127
Cholesterol and Lipoproteins	p. 128
The Diet	p. 132
Fat	p. 134
Protein	p. 136
Carbohydrate	p. 140
Fiber	p. 142
Trace Minerals	p. 144
Conclusion	p. 145
References	p. 146
Pathologic Effects of Malnutrition on the Central Nervous System	p. 161
Introduction	p. 161
Cellular Growth	p. 162
Brain Lipids	p. 165
Brain Metabolism	p. 168
Effects of Malnutrition on Brain Growth and Development	p. 171
Brain Size	p. 172
Brain Composition	p. 175
Malnutrition and Synaptic Development	p. 180
Malnutrition and Energy Metabolism	p. 187
Fatty Acids and Brain Development	p. 188
Malnutrition and Brain Protein	p. 188
Amino Acids and Neurotransmitters	p. 189
Iron Deficiency	p. 189
Catch-Up Growth	p. 190
Brain Function--behavior and Intelligence	p. 190
Conclusions	p. 194
References	p. 196
Dietary Fibers: Aspects of Nutrition, Pharmacology, and Pathology	p. 207
Introduction	p. 207
Dietary Fibers and Their Components	p. 208
Physiological and Pharmacological Responses	p. 217
Therapeutic Applications	p. 233
Undesirable Effects and Pathological Responses	p. 241
Fiber, Bile Acids, and Colon Cancer	p. 246
Conclusions	p. 253
Glossary of Terms	p. 254
References	p. 255
Pathology of Choline Deficiency	p. 279
Introduction	p. 279
Biochemistry of Choline	p. 280
Pathological Lesions Induced by Choline Deficiency	p. 283
Pathogenetic Mechanisms	p. 286
Conclusions	p. 303
References	p. 305
Role of Nutritional Status in Drug Metabolism and Toxicity	p. 321
Introduction	p. 321
Measurement of Drug-Metabolizing Activity	p. 323
Consequences of Dietary Manipulation	p. 324
Protein	p. 325
Undernutrition	p. 332
Carbohydrate	p. 336
Lipids	p. 338
Vitamins	p. 341
Minerals	p. 343
Phase-2 Metabolism	p. 344
Conclusion	p. 346
References	p. 347
Pathological Changes Associated with Drug-Induced Malnutrition	p. 357
Introduction	p. 357
Classifications of Drug-Induced Malnutrition	p. 357
The Pathophysiology of Malabsorption in Drug-Induced Enteropathies	p. 360
Spindle Poisons	p. 364
The Neurotoxicity of Vitamin Antagonists	p. 367
Hepatotoxicity of Vitamin Antagonists	p. 371
Nutrient Depletion Secondary to Drug-Induced Tissue Injury	p. 372
Conclusions	p. 373
References	p. 373
Index	p. 381
Table of Contents provided by Ingram. All Rights Reserved.

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Nutritional Pathology: Pathobiochemistry of Dietary Imbalances

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