Organelle-Specific Pharmaceutical

This book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.

Volkmar Weissig, ScD, PhD is Associate Professor of Pharmacology at Midwestern University in Glendale, Arizona. He has been actively pioneering mitochondrial pharmaceutics for the last decade. The holder of sixteen patents and author of more than eighty research papers, review articles, and book chapters, Dr. Weissig serves as Associate Editor of the Journal of Liposome Research and is the member of several other editorial boards. He is an active member of the International Liposome Society, the Mitochondria Research Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science. Gerard G.M. D'Souza, PhD, is Assistant Professor of Pharmaceutics at Massachusetts College of Pharmacy and Health Sciences in Boston. He has coauthored more than twenty peer-reviewed publications in the fields of pharmaceutical nanotechnology and mitochondrial pharmaceutics. Dr. D'Souza is a member of the editorial board for the journal Drug Delivery and serves as a peer reviewer for several journals in the field of drug delivery.

Preface	p. ix
Contributors	p. xi
An Introduction to Subcellular Nanomedicine: Current Trends and Future Developments	p. 1
Delivery of Nanonsensors to Measure the Intracellular Environment	p. 15
Cytoplasmic Diffiusion of Dendrimers and Dendriplexes	p. 35
Endocytosis and Intracellular Trafficking of Quantum Dot-Ligand Bioconjugates	p. 55
Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and Therapeutic Agents	p. 73
Subcellular Fate of Nanodelivery Systems	p. 93
Intracellular Fate of Plasmid DNA Polyplexes	p. 123
Intracellular Trafficking of Membrane Receptor-Mediated Uptake of Carbon Nanotubes	p. 143
Real-Time Particle Tracking for Studying Intracellular Transport of Nanotherapeutics	p. 161
Tracking Intracellular Polymer Localization Via Fluorescence Microscopy	p. 177
Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for Predicting Uptake and Localization of Nanoparticles in Living Cells? And If Not, Why Not?	p. 193
Self-Unpacking Gene Delivery Scaffolds	p. 207
Cellular Trafficking of Dendrimers	p. 231
Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology	p. 247
Uptake and Intracellular Dynamics of Proteins Internalized by Cell-Penetrating Peptides	p. 263
Cargo Transport by Teams of Molecular Motors: Basic Mechanisms for Intracellular Drug Delivery	p. 289
The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines	p. 311
Peptide-Based Nanocarriers for Intracellular Delivery of Biologically Active Proteins	p. 323
Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro-and Nanoscale Particles	p. 337
Subcellular Targeting of Virus-Envelope-Coated Nanoparticles	p. 357
Mitochondria-Targeted Pharmaceutical Nanocarriers	p. 385
Cell-Penetrating Peptides for Cytosolic Delivery of Biomacromolecules	p. 403
Therapeutic Nano-object Delivery to Subdomains of Cardiac Myocytes	p. 433
Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents	p. 449
Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery Systems	p. 475
Cellular Interactions of Plasmon-Resonant Gold Nanorods	p. 507
Quantum Dot Labeling for Assessment of Intracellular Trafficking of Therapeutically Active Molecules	p. 535
Index	p. 569
Table of Contents provided by Ingram. All Rights Reserved.

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Organelle-Specific Pharmaceutical Nanotechnology

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