The Organic Chemistry of Drug Synthesis, 4 Volume Set

, by Lednicer, Daniel; Mitscher, Lester A.

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ISBN: 9780471531760 | 0471531766
Cover: Hardcover
Copyright: 1/16/1991

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The seventh volume in The definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classes of therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volumes 6. Many of these compounds represent novel structural types first identified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered.

Preface	p. xi
Open-Chain Compounds	p. 1
Peptidomimetic Compounds	p. 2
Antiviral Protease Inhibitors	p. 2
Human Immunodeficiency Virus	p. 2
Human Rhinovirus j	p. 9
Miscellaneous Peptidomimetic Compounds	p. 11
References	p. 19
Alicyclic Compounds	p. 21
Monocyclic Compounds	p. 21
Prostaglandins	p. 21
Antiviral Agents	p. 25
Miscellaneous Monocyclic Compounds	p. 29
Polycyclic Compounds: Steroids	p. 31
19-Nor Steroids	p. 31
Corticosteroid Related Compounds	p. 34
Polycyclic Compounds /	p. 38
References	p. 40
Monocyclic Aromatic Compounds	p. 43
Arylcarbonyl Derivatives	p. 43
Biphenyls	p. 47
Compounds Related to Aniline	p. 50
Compounds Related to Arylsulfonic Acids	p. 53
Diarylmethanes	p. 58
Miscellaneous Monocyclic Aromatic Compounds	p. 60
References	p. 67
Carbocyclic Compounds Fused to a Benzene Ring	p. 69
Indenes	p. 69
Naphthalenes	p. 73
Tetrahydronaphthalenes	p. 74
Other benzofused carbocyclic compounds	p. 79
References	p. 81
Five-Membered Heterocycles	p. 83
Compounds with One Heteroatom	p. 83
Compounds with Two Heteroatoms	p. 91
Oxazole and Isoxazoles	p. 91
Imidazoles and a Pyrrazole	p. 94
Thiazoles	p. 99
Triazoles	p. 103
Tetrazoles	p. 109
References	p. 112
Six-Membered Heterocycles	p. 115
Compounds with One Heteroatom	p. 115
Pyridines	p. 115
Reduced Pyridines	p. 117
Miscellaneous	p. 119
Compounds with Two Heteroatoms	p. 121
Pyrimidines	p. 121
Miscellaneous Six-Membered Heterocycles	p. 133
References	p. 136
Five-Membered Heterocycles Fused to One Benzene Ring	p. 139
Compounds with One Heteroatom	p. 139
Benzofurans	p. 139
Indoles	p. 141
Indolones	p. 148
Miscellaneous Compounds with One Heteroatom	p. 153
Five-Membered Rings with Two Heterocyclic Atoms	p. 156
Benzimidazoles	p. 156
Miscellaneous Compounds	p. 158
References	p. 160
Six-Membered Heterocycles Fused to One Benzene Ring	p. 163
Compounds with One Heteroatom	p. 163
Benzopyrans	p. 163
Quinolines and Their Derivatives	p. 167
Quinolone Antibacterial Agents	p. 172
Compounds with Two Heteroatoms	p. 176
Benzoxazines	p. 176
Quinazolines	p. 178
Miscellaneous Benzo-Fused Heterocycles	p. 184
References	p. 186
Bicyclic Fused Heterocycles	p. 189
Compounds with Five-Membered Rings Fused to Six-Membered Rings	p. 189
Compounds with Two Heteroatoms	p. 189
Compounds with Three Heteroatoms	p. 191
Compounds with Four Heteroatoms	p. 195
Compounds with Two Fused Six-Membered Rings	p. 208
Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams	p. 213
References	p. 215
Polycyclic Fused Heterocycles	p. 217
Compounds with Three Fused Rings	p. 217
Compounds with Four Fused Rings	p. 228
Compounds with Five or More Fused Rings: Camptothecins	p. 230
References	p. 232
Subject Index	p. 233
Cross Index of Biological Activity	p. 241
Cumulative Index	p. 245
Table of Contents provided by Ingram. All Rights Reserved.

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The Organic Chemistry of Drug Synthesis, 4 Volume Set

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Table of Contents

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