Oxford Textbook of Osteoarthritis and Crystal Arthropathy, third edition

Michael Doherty, Head of Department and Director of Clinical & Epidemiological Research, Faculty of Medicine and Health Sciences, University of Nottingham, UK,Hans Bijlsma, Professor of Rheumatology, University of Amsterdam and Free University at Amsterdam, The Netherlands,Nigel Arden, Professor in Rheumatic Diseases, Director of Musculoskeletal Epidemiology and Biobank, University of Oxford, UK,David Hunter, Florance and Cope Chair of Rheumatology Medicine, Royal North Shore Hospital, The University of Sydney, Australia,Nicola Dalbeth, Associate Professor, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand

Professor Michael Doherty MA MD FRCP FHEA is Professor of Rheumatology and Head of Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham. His main research interests are osteoarthritis (OA), gout, calcium pyrophosphate crystal deposition (CPPD), placebo/contextual response and evidence based medicine. He has expertise in clinical and epidemiological studies, community-based clinical trials, systematic reviews and meta-analyses. He has over 300 original research publications and was awarded the OA Research Society International (OARSI) Clinical Research Award for 2012. He is a past editor of Annals of the Rheumatic Diseases (1992-99), has co-chaired EULAR Task Forces for recommendations for OA, gout and CPPD arthritis, and has been involved as a clinical expert in NICE appraisals for OA and gout.


Johannes (Hans) Bijlsma is professor of Rheumatology at the University of Utrecht, as well as at both Universities (VU and UVA) in Amsterdam. He was Head of the Department of Rheumatology and Immunology in Utrecht (1989-2013) and of the Amsterdam Rheumatology and immunology Center (2013-2015).
His main research interests are osteoarthritis (OA), treatment strategies in rheumatoid arthritis and glucocorticoids. He has expertise in clinical and epidemiological studies, randomised controlled clinical trials in early RA, systematic reviews and meta-analyses. He has over 600 original research publications and was awarded the Jan van Breemen Award for his scientific work in the Netherlands (2015). He is an associate editor of Annals of the Rheumatic Diseases (2005 - ongoing), has co-chaired EULAR Task Forces for recommendations for OA and the use of glucocorticoids. He has been the chair of Education of EULAR, the coordinator of the EULAR online courses and is presently the President-elect of EULAR

Nigel Arden is a Professor of Rheumatic Diseases and an International Leader in Epidemiology and predictive modelling and trial design. He has clinical and research expertise in osteoarthritis, arthroplasty and osteoporosis and has published numerous manuscripts based on the use of cohort and large routinely collected databases in musculoskeletal diseases and their treatment. His research interests focus on the epidemiology of musculoskeletal diseases, with a focus on Osteoarthritis and Osteoporosis. He is based in the Botnar Research Centre, University of Oxford with additional sessions at the MRC Lifecourse Epidemiology Unit at the University of Southampton.

Professor David Hunter is a rheumatology clinician researcher whose main research focus has been clinical and translational research in osteoarthritis (OA). He is the Florance and Cope Chair of Rheumatology and Professor of Medicine at University of Sydney, and Staff Specialist at Royal North Shore Hospital and North Sydney Orthopaedic and Sports Medicine Centre. His research is focused on a number of key elements in OA including (but not limited to) the epidemiology of osteoarthritis, the application of imaging to better understand structure and function with application to both epidemiologic research and clinical trials, novel therapies in disease management and heath service system delivery of chronic disease management. He is an editor for leading international journals in his field. He has authored books on osteoarthritis and has over 350 publications in peer reviewed journals.

Professor Nicola Dalbeth is an academic rheumatologist who leads a clinical and laboratory programme of research in gout, an inflammatory arthritis of major significance to Aotearoa New Zealand. Her work focuses on understanding the impact and mechanisms of disease in gout. She is a founding member of the Counties Manukau District Health Board Maori Gout Action Group, and she was the Lead Clinical Advisor for the Gout Clinical Pathways (Greater Auckland Integrated Healthcare Network) and the national bpac Gout Treatment Guidelines. She has served as an Expert Panel member on the American College of Rheumatology Gout Management Guidelines, and is a steering committee member for the OMERACT gout working group and the ACR/EULAR gout classification project.

1. What is Osteoarthritis?
1. What is Osteoarthritis?, Michael Doherty, Nigel Arden, Johannes Bijlsma, Nicola Dalbeth and David Hunter
2. Paleopathology, Juliet Rogers and Paul Dieppe
3. Morphological aspects of pathology, Laura A. Stoppiello and Michael Doherty
2. Tissues
4. Cartilage, Peter M van der Kraan and Esmeralda N Blaney Davidson
5. Pathophysiology of peri-articular bone changes in osteoarthritis, Steven R. Goldring and Richard L. Menschel
6. Osteoarthritis: synovium and capsule, Floris Lafeber, N.J. Besselink and S.C. Mastbergen
7. Neuromuscular, Jason J. McDougall and Joel A. Vilensky
3. Epidemiology
8. Epidemiology, Nigel Arden and Michael C. Nevitt
4. Risk factors
9. Genetics, Ana M Valdes
10. Age, gender, race/ethnicity, and socioeconomic status in osteoarthritis and its outcomes, Joanne M. Jordan, Kelli D. Allen and Leigh F. Callahan
11. Morphology, Richard Aspden and Jenny Gregory
12. Lifestyle, J. Runhaar and S.M.A. Bierma-Zeinstra
5. Pain
13. Neurobiology of pain in osteoarthritis, Philip Mease
14. Contextual aspects of pain; why does the patient hurt?, David A Walsh
6. Clinical assessment
15. Clinical assessment: signs, symptoms and patient perceptions in osteoarthritis, Margreet Kloppenburg
16. Radiography and Computed Tomography Imaging of Osteoarthritis, Daichi Hayashi, Ali Guermazi and Frank W. Roemer
17. Ultrasound in osteoarthritis and crystal-related arthropathies, Walter Grassi, Tadashi Okano and Emilio Filippucci
18. Imaging - MRI, David Hunter and Frank Roemer
19. Laboratory tests, Leticia Alle Deveza, Changhai Ding, Xingzhong Jin, Xia Wang, Zhaohua Zhu and David Hunter
7. Management
20. Introduction: the comprehensive approach, Michael Doherty, Nigel Arden, Johannes Bijlsma, Nicola Dalbeth and David J. Hunter
21. Patient information strategies for decision making and management of osteoarthritis, Gillian Hawker, Anne Lyddiatt, Linda Li, Dawn Stacey, Susan Jaglal, Sarah Munce and Esther Waugh
22. Exercise for the person with osteoarthritis, Kim L Bennell, Ans Van Ginckel, Fiona Dobson and Rana S Hinman
23. Weight loss, Marius Henriksen, Robin Christensen, Berit L. Heitmann and Henning Bliddal
24. Addressing adverse mechanical factors, Christelle Nguyen and Francois Rannou
25. Psychological strategies in osteoarthritis of the knee or hip, Joost Dekker, Daniel Bossen, Jasmijn Holla, Mariette de Rooij, Cindy Veenhof and Marike van der Leeden
26. Miscellaneous Physical Therapies, MA Holden, MJ Thomas and KS Dziedzic
27. Placebo, nocebo and contextual effects, Dr. A. Abhishek and Prof. M. Doherty,
8. Pharmacological therapies
28. Topical pharmacologic treatments, Dr A Abhishek, Dr Adrian Jones and Professor Michael Doherty
29. Systemic analgesics (including paracetamol and opioids), Bernard Bannwarth and Francis Berenbaum
30. Non-steroidal anti-inflammatory drugs, Lee S. Simon and Marc C. Hochberg
31. Supplements for the treatment of Osteoarthritis, Allen D Sawitzke and Daniel O Clegg
32. Intra-articular injection therapy, Nigel Arden and Terence O'Neill
9. Surgery
33. Arthoplasty and its complications, Andrew Price, Paul Monk and David Beard
34. Other surgical approaches in the management of osteoarthritis, Jonas Bloch Thorlund and L. Stefan Lohmander
10. Prospects for disease modification
35. Prospects for disease modification, Shirley Pei-Chun Yu and David John Hunter
11. Delivery of care
36. Delivery (organisation and outcome), Caroline A Brand and Ilana N Ackerman
12. Guidelines
37. Guidelines, Weiya Zhang and Michael Doherty
13. Gout
38. Epidemiology of gout, Samantha Hider and Edward Roddy
39. Pathophysiology of gout, Nicola Dalbeth
40. The genetic basis of gout, Tony R Merriman
41. Clinical presentation of gout, Tim L Jansen
42. Laboratory investigations in gout, Eliseo Pascual and Francisca Sivera
43. Imaging of gout, Robert T. Keenan, Sneha Pai and Naomi Schlesinger
44. Principles of gout management, Pascal Richette
45. Treatment of acute gout, Puja Khanna
46. Long-term management of gout, Fernando Perez-Ruiz, Irati Urionaguena and Sandra P. Chinchilla
47. Asymptomatic hyperuricaemia - to treat or not to treat?, Thomas Bardin
14. Calcium pyrophosphate crystal deposition
48. Epidemiology and risk factors for calcium pyrophosphate deposition, Dr A Abhishek and Professor Michael Doherty
49. Pathophysiology of calcium pyrophosphate deposition, Dr A Abhishek and Professor Michael Doherty
50. Clinical features of calcium pyrophosphate crystal deposition, Dr A Abhishek and Professor Michael Doherty
51. Investigations of calcium pyrophosphate deposition, Dr A Abhishek and Professor Michael Doherty
52. Treatment of calcium pyrophosphate deposition, Dr A Abhishek and Professor Michael Doherty
15. Basic calcium phosphates
53. Basic calcium phosphates and osteoarthritis, Nicola Dalbeth