Oxford Textbook of Sjögren's Syndrome

Sjögren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know.

The Oxford Textbook of Sjögren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.

Elizabeth J Price, Consultant Rheumatologist, Great Western Hospital NHS Foundation Trust, Swindon, UK,Anwar R Tappuni, Honorary Consultant in Oral Medicine, Institute of Dentistry, Queen Mary University of London

Dr Elizabeth J Price is a consultant rheumatologist who has a specific interest in Sjogren's Syndrome and runs a specialist Sjogren's clinic at the Great Western Hospital in Swindon. Her interest in Sjogren's dates from her Research Fellowship at The Kennedy Institute in London where she completed an MD thesis focusing on Sjogren's syndrome. She currently focuses on extraglandular manifestations of the disease and clinical research into SS and was the lead author and driving force behind the BSR Guidelines for the management of Sjogren's syndrome.


Dr Anwar R Tappuni is Reader/Honorary Consultant in Oral Medicine, Institute of Dentistry, Queen Mary University of London, UK

Section 1: Introduction
1.1. Introduction, Elizabeth J. Price and Anwar R. Tappuni
1.2. Historical background, classification and diagnostic criteria, Caroline Shiboski and Troy E. Daniels
1.3. Epidemiology and genetics of Sj?gren s Syndrome, Simon Bowman
Section 2: Basic science
2.1. Biomarkers in primary Sj?gren sSyndrome, Onorina Berardicurti, Charlotte G. Smith, Roberto Giacomelli, Elizabeth J. Price, and Francesca Barone
2.2. Autoantibodies and autoantigens in Sj?gren s Syndrome, Aur?lie Ambrosi, Albin Bj?rk, and Marie Wahren-Herlenius
2.3. Stromal cells in Sj?gren s Syndrome, Saba Nayar, Serena Colafrancesco, and Francesca Barone
Section 3: Diagnostic investigations
3.1. Clinical assessment of salivary glands function, Anwar R. Tappuni
3.2. Biopsy gland biopsy procedure and histopathology, Benjamin Fisher
3.3. Imaging in Sj?gren s Syndrome, Ashok Adams
Section 4: Head and neck manifestations and clinical management
4.1. Salivary glands manifestations and management, Emily Carter
4.2. Oral manifestations and management, Anwar R. Tappuni
4.3. Dental related disease, Jennifer Fuller and Shakeel Shahdad
Section 5: Ocular manifestations and management
5.1. Ocular Manifestations of Sj?gren s Syndrome, Nicola Roper, Pasquale Aragona, Maurizio Rolando, and Francisco C Figueiredo
5.2. A therapeutic strategy for Sj?gren s Syndrome dry eye, Nicola Roper, Pasquale Aragona, Maurizio Rolando, and Francisco C Figueiredo
Section 6: Systemic manifestations
6.1. Cutaneous involvement and management of Sj?gren s Syndrome, Thomas J Tull, Emma Benton, and David D Cruz
6.2. Musculoskeletal disease - presentation and management, Elizabeth J. Price
6.3. Renal involvement in Primary Sj?gren's Syndrome, Rhys Evans and Stephen Walsh
6.4. Gastrointestinal Disease in Sj?gren s syndrome, Elizabeth J. Price
6.5. Neurological complications of Sj?gren s Syndrome, Aravind Ganesh, Shane Lyons, and Gabriel Yiin
6.6. Cardiovascular and Lung Manifestations of Sj?gren s Syndrome, Sara Carty
6.7. Haematological Manifestations of Sj?gren s Syndrome, Coziana Ciurtin and Su-Ann Yeoh
6.8. Fatigue in Sj?gren s Syndrome, Coziana Ciurtin and Su-Ann Yeoh
6.9. Non-pharmacological interventions for the management of Fatigue and Constitutional Symptoms in Sj?gren s Syndrome, Katie Hackett and Helen Cartner
6.1. Gynaecologic and obstetric aspects in Sj?gren s Syndrome, Roberta Priori, Antonina Minniti, and Serena Colafrancesco
6.11. Sj?gren s Syndrome Associated Lymphoma, Saad Rassam
Section 7: Juvenile and young adult
7.1. Juvenile and young adult onset Sj?gren s Syndrome, William D. Renton, Elizabeth J. Price, and A.V. Ramanan
Section 8: Sjogren s mimics and overlaps
8.1. Mimics of Sj?gren s Syndrome, Nurhan Sutcliffe
8.2. Sj?gren s Syndrome overlaps, Nurhan Sutcliffe and Arabella Waller
Section 9: Experimental treatments, emerging therapies and the future
9.1. Experimental therapies in primary Sj?gren s Syndrome, Benjamin Fisher
9.2. Sj?gren s Syndrome Summary of Clinical Management, Elizabeth J. Price and Alan Baer