Parkinsonian Disorders in Clinical Practice

This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come. It is split into three sections:Section 1: A compilation of the major brain lesions typically seen in PDSection 2: Treatment options in PDSection 3: 25 cases designed to test the reader and the practical application of the information supplied in the other sections.

Anthony HV Schapira, MD DSC, FRCP, FMedSci, Professor and Head of Department University College of Clinical Neurosciences, Institute of Neurology, University College London, Queen Square, London UK. Professor of Neurology, National Hospital for Neurology and Neurosurgery and Roayl Free Hospital, London, UK.

Andreas Hartmann, MD, Clinical Investigation Center, Pitie-Salpetriere Hopital, Paris, France. Federation of Nervous System Disease, Pitie-Salpetriere Hopital, Paris, France. National Institute of Health and Medical Research, Paris, France. Pierre and MAric Curie University,?Paris, France.

Yves Agid, MD, PhD, Clinical Investigation Center, Pitie-Salpetriere Hopital, Paris, France. Federation of Nervous System Disease, Pitie-Salpetriere Hopital, Paris, France. National Institute of Health and Medical Research, Paris, France. Pierre and MAric Curie University,?Paris, France.

Preface
Introduction
What is Parkinson's disease? From pathophysiology to symptoms
Pathophysiology of Parkinson's disease
Dysfunctions of the main neuronal pathways in Parkinson's disease
An overview of neuronal systems affected in Parkinson's disease
Dopaminergic neurons
Non-dopaminergic neurons
Consequences of dopaminergic neuronal lesions on basal ganglia circuits
The dopaminergic nigrostriatal system: pre- and postsynaptic compensatory mechanisms
Pathologic alterations of nigrostriatal circuits in Parkinson's disease
Histopathology of Parkinson's disease
The etiopathogenesis of Parkinson's disease
The genetics of Parkinson's disease: any clues for the sporadic forms?
Relevant environmental factors: focus on mitochondria
Mechanisms of cell death in Parkinson's disease: therapeutic implications
Conclusions
Parkinson's disease or Parkinson's syndromes?
What Parkinson's disease is not
Clinical features of Parkinson's disease
Motor symptoms
Non-motor symptoms
Depression
Apathy
Cognitive impairment
Sleep
Autonomic dysfunction
Sensory symptoms
The different forms of Parkinson's disease: relevance for prognosis
The differential diagnosis of Parkinson's disease
Treatment-related symptoms
Motor complications
Non-motor complications
Treatment of Parkinson's disease
Antiparkinsonian agents
Levodopa
COMT inhibitors
Dopamine agonists
Monoamine oxidase B inhibitors
Other drugs
Medical management
Initiation of treatment
Maintenance of treatment (Fig. 2.7)
Motor complications
Management of non-motor complications
Non-medical management
Surgery
Destructive lesions
Cell therapy
Growth factors
Neuroprotection
MAO-B inhibitors
Dopamine agonists
Coenzyme Q
Creatine
Antiapoptotic drugs
Conclusion
Case studies
Case studies-diagnostic index
Index
Table of Contents provided by Publisher. All Rights Reserved.

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Parkinsonian Disorders in Clinical Practice

Summary

Author Biography

Table of Contents

Supplemental Materials