Johns Hopkins Univ., Baltimore, MD. Covers all emerging aspects of Parkinson's disease. Topics include neuropathology, genetics, treatment, genetic risk factors, mouse models of recessive Parkinsonism, drosophilia models of Parkinson's disease, and more. For clinicians, researchers, and students.
Preface
p. iii
Contributors
p. vii
Overview
Neuropathology and Staging of Parkinson's Disease
p. 1
Genetics of Parkinson's Disease
p. 19
Epidemiology of Parkinson's Disease
p. 35
Treatment of Parkinson's Disease
p. 53
Genetics
Genetics of [alpha]-Synuclein
p. 75
Clinical and Genetic Features of PARKIN-Related Parkinson's Disease
p. 83
Genetics: DJ-1 in Parkinson's Disease
p. 99
PINK1 Parkinsonism
p. 115
LRRK2: Genetics and the Pathogenic Mechanisms of Parkinsonism
p. 127
Genetics of Tau in Parkinsonism
p. 135
Genetic Risk Factors for Parkinson's Disease
p. 153
Pathogenesis
[alpha]-Synuclein and Parkinson's Disease
p. 167
Tau in Parkinsonian Diseases
p. 187
The Role of PARKIN in Parkinson's Disease
p. 199
Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis
p. 219
The Ubiquitin-Proteasome System in Parkinson's Disease
p. 237
Animal Models
Transgenic Models of [alpha]-Synucleinopathy
p. 251
Mouse Models of Recessive Parkinsonism
p. 269
Drosophila Models of Parkinson's Disease
p. 287
Caenorhabditis elegans Models of Parkinson's Disease
p. 311
The MPTP Model of Parkinson's Disease
p. 325
Rotenone Model for Parkinson's Disease
p. 351
Drug Trials in Animal Models of Parkinson's Disease
p. 367
Index
p. 379
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